检索结果-南通市图书馆

Fertilization of IVF/ICSI Using Sibling Oocytes from Couples with Subfertile Male or unexplained infertility

Journal of Huazhong University of Science and Technology(Medical Sciences) 2004年第4期24卷 365-368,384页

作者：李志凌林虹肖婉芬王玉莲 Center of Reproduction the First Affiliated Hospital of Shantou University Medical College

The significance of the performance of conventional in vitro fertilization and intracytoplasmic sperm injection (IVF/ICSI) using sibling oocytes from couples with subfertile male or unexplained infertility was evaluated. A total of 410 sibling oocyte cumulus-corona complexes (OCCC) from 21 couples with subfertile male (group A) and 11 unexplained infertile couples (group B) were randomly divided, in order of retrieval, into two groups inseminated either by conventional IVF or by ICSI. The treatment outcomes and the influence of infertility factors on fertilization in each group were compared. The results showed that although the two pronuclear (2PN) fertilization rate per injected sibling oocytes was significantly higher after ICSI (group A: 68.2 %±28.8 %; group B: 66.2 %±24.9 %) than after conventional IVF (group A: 41.8 %±32.7 %; group B: 40.1 %±22.1 %), the other variables studied included: the fertilization rates of per allocated sibling oocytes IVF/ICSI, the fertilization rates of sibling oocytes IVF/ICSI after excluding failed IVF fertilization cycles, as well as the cleavage rates of normal fertilization were not statistically significant (P>0.05). Similarly, though the total fertilization failure rate in the IVF group (group A: 42.9 %; group B: 36.4 %) was significantly higher than in the ICSI group (group A: 4.8 %; group B: 0), we did not cancel cycles due to the normal fertilization of sibling oocytes. Embryo transfer was possible in all 32 couples. There were 10 clinical pregnancies in the two groups. We also discovered a possible association between some semen parameters and sperm functions of group A, and women age and duration of infertility of group B and fertilization. It is suggested that adoption of the split IVF/ICSI technology in the above cases may help eliminate fertilization failures. This is also a useful method to investigate the effect of single factor on the employment of assisted reproductive technology.

关键词： sibling oocytes in vitro fertilization intracytoplasmic sperm injection subfertile male infertility unexplained infertility

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Clinical pregnancy rate of women with unexplained infertility with or without cervical mucus aspiration before intrauterine insemination: A randomized controlled trial

引用

Asian pacific Journal of Reproduction 2022年第6期11卷 247-252页

作者： Richa Vatsa Vanita Suri Shalini Gainder Aashima Arora Japleen Kaur Neelam Choudhary Shruti Sharma Department of Obstetrics and Gynaecology Postgraduate Institute of Medical Education and ResearchChandigarh 120012India Department of Obstetrics and Gynaecology All India Institute of Medical SciencesNew Delhi 110029India Department of Obstetrics and Gynaecology Dr B R Ambedkar Institute of Medical Sciences56 ASector 56SAS NagarPunjab 160055India

Objective:To detect effect of removing cervical mucus before performing intrauterine insemination(IUI)on pregnancy rate in patients with unexplained ***:The randomized controlled trial was conducted in infertility Division of Department of Obstetrics and Gynaecology of a tertiary care *** 80 patients of unexplained infertility were *** computer generated block randomization in block size of 4 and 6,patients were randomly allocated at time of starting ovarian stimulation into the cervical mucus removal group or the non-removal of cervical mucus group before IUI,40 in each *** stimulation with clomiphene 100 mg from day 2-6 of menstrual cycle along with human menopausal gonadotropin 150 IU was given alternate day starting from day *** monitoring was done and further doses given as per response;trigger was planned when 1-3 follicle reach a diameter of>18 *** was planned after *** was done as per the group *** cleaning was done in the cervical mucus removal group by aspirating mucus with IUI syringe and sterile cotton swab before *** primary outcome was clinical pregnancy *** of difficult IUIs and cycle cancellation due to ovarian hyperstimulation were also ***:IUI was not done in 4 patients due to *** per IUI cycle occurred in 7.9%(3/38)in the cervical mucus removal group and 21.1%(8/38)in the non-removal of cervical mucus *** was no statistically significant difference in clinical pregnancy rate between two groups(P=0.19).Conclusions:There is a trend towards a lower clinical pregnancy rate with removal of cervical mucus before IUI in women of unexplained infertility though the difference is not statistically *** studies with large sample size need to be done on this intervention.

关键词： unexplained infertility Intrauterine insemination Cervical mucus removal Pregnancy outcome Randomized controlled trial

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Serum leptin level in Sudanese women with unexplained infertility and its relationship with some reproductive hormones

引用

World Journal of Biological Chemistry 2022年第5期13卷 83-94页

作者： Abdullah Abdulslam Abdullah Musa Ahmed Adesina Oladokun Nasir Adam Ibrahim Shahd Nourain Adam Department of Reproductive Health Sciences Pan African University Life and Earth Sciences InstituteUniversity of IbadanIbadan 119OyoNigeria Department of Obstetrics and Gynecology College of MedicineUniversity of IbadanIbadan 119OyoNigeria Department of Biomedical Sciences Faculty of Veterinary SciencesUniversity of GadarifGadarif 208Sudan Department of Veterinary Surgery Faculty of Veterinary MedicineAL-Salam UniversityAl-fula 120West KordofanSudan Department of Biology Faculty of ScienceImam Mohammed Ibn Saud Islamic UniversityRiyadh 13318Saudi Arabia Department of Biochemistry and Physiology Faculty of Veterinary MedicineUniversity of Al-butanaRuffaa 210Sudan College of Nursing University of BahriKhartoum 12217Sudan

BACKGROUND The excessive concentration of leptin has negative effects on all aspects of female *** this established relationship,the exact role of leptin in women’s fertility is not clear enough and needs more *** To evaluate the serum leptin levels in Sudanese women and to ascertain the relationship between serum leptin levels and unexplained infertility(UI).METHODS A matched(age and body mass index)case-control study was conducted from March 2021 to February *** study samples were 210 women with UI and 190 fertile women of reproductive age who were attending the maternity hospitals and fertility clinics in Khartoum state *** serum concentration of leptin and other serum biomarkers were determined using enzyme-linked immunosorbent *** The results showed that there was a highly statistically significant difference between the two groups(P0.80),for leptin level,LH/FSH ratio,PRL level,and E2/T ratio,and large(effect size 0.50-≤0.80)for FSH and *** This study reveals that leptin could be a potential biomarker for UI in Sudanese women and it may be useful for identifying women with a high risk of infertility.

关键词： Leptin Serum level unexplained infertility Sudanese women Reproductive hormones

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Leptin levels in women with unexplained infertility:A systematic review and meta-analysis

引用

World Journal of Meta-Analysis 2022年第1期10卷 37-45页

作者： Abdullah Abdulslam Abdullah Musa Ahmed Adesina Oladokun Department of Reproductive Health Sciences Pan African University Life and Earth Sciences InstituteUniversity of IbadanIbadan 119Oyo StateNigeria Department of Biomedical Sciences Faculty of Veterinary SciencesUniversity of GadarifGadarif 208Sudan Department of Veterinary Surgery Faculty of Veterinary MedicineAL-Salam UniversityAl-Fulla 209West KordofanSudan Department of Obstetrics and Gynecology Department of EpidemiologyUniversity College HospitalIbadan 119Oyo stateNigeria

BACKGROUND unexplained infertility(UI)is usually used for any heterosexual couple who failed to have a successful clinical pregnancy without identifying clear causes after they undergo all standard fertility *** shows that leptin is one of the most accurate biomarkers for ***,conflicting results regarding leptin levels in women with UI have been *** To find the serum leptin levels in women with *** All studies written in English and conducted before April 30,2021 from PubMed/MEDLINE,Embase,Cochrane Central Register of Controlled Trials,***,Google Scholar,OpenGrey,OATD,and the infertility conference abstract were *** were found eligible if they provided the mean and standard deviation of leptin for the case group and control *** quality assessment of individual studies was evaluated using the Joanna Briggs Institute Quality Assessment *** synthesis and statistical analysis were done using STATA software version *** A total of 378 studies were reviewed,and just six studies that fulfilled the eligibility criteria were included in this *** pooled result showed that leptin levels were significantly higher in women with UI compared to fertile women,with a standardized mean difference of 0.97(95%confidence interval:-0.49-2.43).However,heterogeneity across studies was highly significant(Pinfertility.

关键词： Leptin Meta-analysis Serum level unexplained infertility Women

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Timed Intercourse versus Intrauterine Insemination with Mild Ovarian Stimulation for unexplained infertility

引用

Open Journal of Obstetrics and Gynecology 2022年第12期12卷 1279-1288页

作者： Hany Mahmoud Abd El Hamid Manal Abdel-Wanees Alsayed Hesham Mohammed Hamed Shaimaa Belal Department of Obstetrics and Gynecology El-Sahel Teaching Hospital Cairo Egypt Department of Obstetrics and Gynecology Faculty of Medicine Helwan University Helwan Egypt

Background: infertility is unexplained in about 22% - 28% of infertile couples. Spontaneous pregnancy may occur in them. If did not happen, Expectant management will be via clomiphene citrate (CC) administration, intrauterine insemination (IUI), and IVF & ICSI. Aim: to assess the effectiveness of intrauterine insemination with mild controlled ovarian stimulation compared with expectant management in couples with unexplained infertility more than one year. Methods: 160 couples with unexplained infertility were selected, The couples were randomly divided into two groups: Group (A) “80 couples”: Intrauterine insemination (IUI) with mild controlled ovarian stimulation (combination of CC + hMG) using prepared semen and was performed 36 hours after hCG injection, Group (B) “80 couples”: Couples had no ovulation induction. They encouraged for timed intercourse in the most fertile days of female cycle guided by folliculometry for 6 months. Data were collected quantitatively, coded and analyzed using SPSS. The power of study is 80% and 95% confidence interval. Result: The pregnancy rate was calculated in both groups: In group (A) (IUI/COS): OPR (Ongoing pregnancy rates) was 27.5% and PR (pregnancy rates)/cycle was 8.6%. In group (B) (Expectant management): OPR was 25% and PR/cycle was 5.3%. Conclusion: Mild controlled ovarian stimulation CC + hMG with IUI offers no statistical significance in terms of pregnancy outcomes over expectant management in this study however significance in the response to stimulation.

关键词： Intrauterine Insemination Ovarian Stimulation unexplained infertility

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Antioxidant Supplement Improves the Pregnancy Rate in Patients Undergoing in Vitro Fertilization for unexplained infertility

引用

Open Journal of Obstetrics and Gynecology 2019年第1期9卷 1-9页

作者： Ayse Z.Ozdemir Bulent Ayas Davut Guven Abdulkadir Bakay Pervin Karl? Ondokuz Mayis University IVF Center Ondokuz Mayis University HospitalSamsunTurkey Department of Obstetrics and Gynaecology Ondokuz Mayis University HospitalSamsunTurkey Amasya University Department of Obstetrics and GynecologyAmasyaTurkey

Objective: This is a retrospective study to evaluate the effect of using the antioxidants containing coenzyme Q10 (CoQ10) and omega-3 in patients undergoing in vitro fertilization and intracytoplasmic sperm injection (IVF-ICSI) for unexplained infertility. Materials Methods: A total of 299 patients undergoing IVF-ICSI for unexplained infertility at the IVF center of Ondokuz Mayis University were studied. The subject group consisted of 135 patients who used OMEPA Q10 (Co Q10 100 mg, omega-3 600 mg, eicosapentaenoic acid 300 mg, docosahexaenoic acid 230 mg) for two months before ovarian stimulation. A group of 164 patients who did not use the supplement were evaluated as the control group. Results: The pregnancy rate of patients using antioxidants was statistically higher than that of those who did not use the supplement (p 0.05). The pregnancy rates of patients in the two groups were 32.9% and 49.6% respectively. The pregnancy rate of patients using antioxidants was statistically higher than that of those who did not use the supplement (p 0.05) seemed not enough. Conclusion: We concluded that using antioxidants that contain Co Q10 and omega-3 in patients undergoing IVF-ICSI for unexplained infertility increased the clinical pregnancy rate. We recommend using antioxidants that contain Co Q10 and omega-3 in infertile patients.

关键词： CoQ10 Omega-3 Antioxidant unexplained infertility In Vitro Fertilization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Characterization and risk factors for unexplained female infertility in Sudan:A case-control study

引用

World Journal of Methodology 2023年第3期13卷 98-117页

作者： Abdullah Abdulslam Abdullah Musa Ahmed Adesina Oladokun Reproductive Health Sciences Program Pan African University Life and Earth Sciences InstituteUniversity of IbadanIbadan 119Oyo stateNigeria Department of Obstetrics and Gynecology College of MedicineUniversity of IbadanIbadan 119Oyo stateNigeria Department of Biomedical Sciences Faculty of Veterinary SciencesUniversity of GadarifAl-Gadarif 32211Sudan Department of Veterinary Surgery Faculty of Veterinary MedicineAL-Salam UniversityAl-fula 120West KordofanSudan

BACKGROUND Female infertility with unknown causes(unexplained)remains one of the mysteries in the reproductive health field,where the diagnostic evidence is still weak and the proposed treatments still work with unknown ***,several studies have proposed some possible causes and risk factors for unexplained female *** To characterize and identify factors associated with unexplained infertility in Sudanese *** A matched(age and body mass index)case-control study was conducted from March 2021 to February *** study samples were 210 women with unexplained infertility(UI)and 190 fertile women of reproductive age who were attending the maternity hospitals and fertility clinics in Khartoum,*** risk factors of unexplained infertility were identified using a structured,pretested questionnaire containing information on socio-demographic variables,anthropometrics,clinical diagnosis of infertility,behavioral factors,physical activity assessment,diversity,and consumption of different food groups by the study *** The results showed a higher proportion of women diagnosed with UI were residents of rural areas than controls(21.4%vs 11.1%,Pinfertility(explained and unexplained)compared with ***,after controlling for the effects of potentially confounding variables using multivariable logistic regression analysis,only marital status,family history of infertility,use of modern contraceptives,smoking,caffeine consumption,physical activity level,meals consumed,other vitamin-A-rich fruits and vegetables,and other vegetables were found to be significant(Punexplained infertility among Sudanese *** Married women with a family history of infertility

关键词： unexplained infertility Sudanese women Risk factors Dietary diversity Physical activity level

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Methylene Tetra-Hydrofolate Reductase Gene Polymorphism and Endometrial Perfusion in unexplained Female infertility

引用

Open Journal of Obstetrics and Gynecology 2022年第5期12卷 386-393页

作者： Eman Aly Abd El Fattah Faculty of Medicine Alexandria University Alexandria Egypt Department of Obstetrics and Gynecology Shatby Maternity Hospital Alexandria Egypt

Aim of the study: Examing the role of Methylene tetra-hydrofolate reductase (MTHFR C677T) polymorphisms in unexplained female infertility. Methods: The study was conducted on women with unexplained infertility attending the infertility Clinic at El-Shatby University Hospital, Alexandria, during the period from October 2020 to October 2021. Uterine artery Doppler assessment and detection of MTHFR C677T gene mutation were done. The frequencies of homozygous and heterozygous gene mutations were determined. Results: In group I, 35 cases had abnormal uterine artery Doppler compared to 22 normal cases in group II. As regards MTHFR C677T gene mutation, 19 cases were positive in group I (7 were homozygous and 12 were heterozygous) and only one case was positive in group II (heterozygous) which was statistically significant. Conclusion: MTHFR C677T gene polymorphisms may play a role in unexplained infertility.

关键词： unexplained infertility Uterine Doppler MTHFR Gene Polymorphism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

不明原因不孕患者子宫内膜种植窗口期MMP-9及其抑制物TIMP-1的表达

不明原因不孕患者子宫内膜种植窗口期MMP-9及其抑制物TIMP-1的表达

引用

作者：洪丽华浙江大学

学位级别：硕士

不孕症是妇科常见病之一，据国外统计发病率为10～25％，多数病人经过标准检查程序能明确病因，但仍有许多夫妇虽然经过各项不孕检查未找到不孕原因，这类不孕被称为不明原因不孕症。这些患者的生育力处于一种亚临床不孕状态，这种亚临... 详细信息

不孕症是妇科常见病之一，据国外统计发病率为10～25％，多数病人经过标准检查程序能明确病因，但仍有许多夫妇虽然经过各项不孕检查未找到不孕原因，这类不孕被称为不明原因不孕症。这些患者的生育力处于一种亚临床不孕状态，这种亚临床的异常，如果已经排除排卵障碍，可能发生在受精、着床等过程中的任何一个环节，并导致不孕，然而，作为治疗不孕症最终手段的IVF-ET，每个促排卵周期受精成功率较高，而妊娠成功率却较低，另外，人群中有22％的妊娠在还未得到临床诊断前即发生流产，这些现象使得着床障碍在不明原因不孕症中的作用越来越受到人们的重视。着床成立的重要条件是胚胎和子宫内膜的同步发育与协调配合，其中子宫内膜容受性是关键因素。子宫内膜只有在接受期或种植窗(window for implantation)期，即在排卵后第6-10天，才能接受胚胎植入。胚胎植入(embryo implantation)是指从卵子受精到胚泡着床的一系列细胞或分子生物学事件，胚泡侵入母体组织至少需要3个因素：(1)细胞和细胞外基质(extracellular matrix，ECM)的黏附;(2)着床部位ECM极性降解;(3)穿透ECM。近年来，随着分子生物学和免疫学的飞速发展，研究手段不断更新，了解到胚胎着床是一个及其复杂和精细的过程，胚泡接触、黏附，并植入子宫内膜受到多方面因素的调节，而调节子宫内膜和早期妊娠蜕膜的发育，浙江大学硕士学位论文促进胚泡种植主要是通过性激素一免疫细胞一细胞因子（生长因子）一勤附分子网络的调节来实现的。其中第一和第三个过程需要基质蛋白的细胞表面受体如整合素（integrns）的参与，第二阶段则需要能够降解 ECM的相应酶类，其中就涉及到近年来越来越为人们所肯定的MMPS及其自身抑制物hMPS等。基质金属蛋白酶（Main Metallonroteinases，MMPs）是一类具有许多共同生化特性的、可降解细胞外基质的蛋白水解酶类，它广泛分布在人体各种组织和器官内，近年来的研究发现子宫内膜也可分泌MMPs，这些酶可能参与子宫内膜的重建、囊胚种植及滋养层浸润。子宫内膜蜕膜化需要MMPS的参与。有研究发现MMP－9及其抑制物TIMP－l在子宫内膜分泌期表达增加，尤其是在子宫内膜种植窗口期呈现强阳性表达，因此推测其与子宫内膜容受性有关，认为MM－9、TIMP－l在这一时期的强阳性表达有助于加强蛋白水解酶活性，完成细胞外基质的转化，促进子宫内膜的分化和蜕膜化，使子宫内膜更适合胚胎植入，改善于宫内膜容受性，为胚胎着床做准备。目前，虽然MMPs在正常子宫内膜周期性变化、子宫内膜异位症、妊娠等方面的研究较多，但是MMPs在于宫内膜容受性及不明原因不孕症中的研究甚少，尤其是在不明原因不孕症中的作用，国内外均未见有文献报道。本实验选取18例不明原因不孕患者为实验组，其中原发不孕14例，继发不孕4 例。不孕年限2年一13年，平均3．33上2尸2年。15例有生育功能的妇女为对照组。基础体温升高第6－9天，采血测血清雌二醇（EZ）、孕酮（P）浓度（批内差异＜m％）;子宫内膜活检石蜡切片SP法免疫组化测定子宫内膜MMP．9、TIMPI、PR，石蜡切片进行HE染色，用免疫组化组织积分法（H－SCORE）对免疫组化结果进行半定量分析。了解MMPg、TIMP－l在分泌中期子宫内膜中的表达及子宫内膜PR的关系，探讨子宫内膜局部基质金属蛋白酶类表达异常在不明原因不孕症发病中的意义，进一步证实基质金属蛋白酶类在调节子宫内膜容受性中的意义及其与不明原因不孕症的关系。 3 浙江大学硕士学位论文结果： 1．于宫内膜MMP－9的表达子宫内膜MMP－9在着床窗口期子宫内膜表面上皮、腺体和间质中呈阳性表达，表达定位于细胞浆，腺体表达较间质强，实验组子宫内膜表面上皮、腺体、间质MMP－9免疫组化H－Score积分值较对照组低，比

关键词： unexplained infertility implantation window phase matrix metalloproteinases tissue inhibitor of metal loproteinase endometrial receptivity

来源：

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：