Serum leptin level in Sudanese women with unexplained infertility and its relationship with some reproductive hormones

作     者：Abdullah Abdulslam Abdullah Musa Ahmed Adesina Oladokun Nasir Adam Ibrahim Shahd Nourain Adam 

作者机构：Department of Reproductive Health SciencesPan African University Life and Earth Sciences InstituteUniversity of IbadanIbadan 119OyoNigeria Department of Obstetrics and GynecologyCollege of MedicineUniversity of IbadanIbadan 119OyoNigeria Department of Biomedical SciencesFaculty of Veterinary SciencesUniversity of GadarifGadarif 208Sudan Department of Veterinary SurgeryFaculty of Veterinary MedicineAL-Salam UniversityAl-fula 120West KordofanSudan Department of BiologyFaculty of ScienceImam Mohammed Ibn Saud Islamic UniversityRiyadh 13318Saudi Arabia Department of Biochemistry and PhysiologyFaculty of Veterinary MedicineUniversity of Al-butanaRuffaa 210Sudan College of NursingUniversity of BahriKhartoum 12217Sudan 

出 版 物：《World Journal of Biological Chemistry》 (世界生物化学杂志（英文版）（电子版）)

年 卷 期：2022年第13卷第5期

页      面：83-94页

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

基　　金：the Pan African University of Life and Earth Sciences Institute the African Union for financial support the University of Ibadan for hosting this Ph D program 

主　　题：Leptin Serum level Unexplained infertility Sudanese women Reproductive hormones 

摘      要：BACKGROUND The excessive concentration of leptin has negative effects on all aspects of female *** this established relationship,the exact role of leptin in women’s fertility is not clear enough and needs more *** To evaluate the serum leptin levels in Sudanese women and to ascertain the relationship between serum leptin levels and unexplained infertility(UI).METHODS A matched(age and body mass index)case-control study was conducted from March 2021 to February *** study samples were 210 women with UI and 190 fertile women of reproductive age who were attending the maternity hospitals and fertility clinics in Khartoum state *** serum concentration of leptin and other serum biomarkers were determined using enzyme-linked immunosorbent *** The results showed that there was a highly statistically significant difference between the two groups(P0.80),for leptin level,LH/FSH ratio,PRL level,and E2/T ratio,and large(effect size 0.50-≤0.80)for FSH and *** This study reveals that leptin could be a potential biomarker for UI in Sudanese women and it may be useful for identifying women with a high risk of infertility.