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18F-FDG-PET for Assessing Biological Viability and Prognosis in Liver Transplant Patients with Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2017年第3期5卷 224-234页

作者： Arno Kornberg Martina Schernhammer Helmut Friess Department of Surgery Klinikum rechts der Isar Technical University Munich Germany

Liver transplantation (LT) has become standard of care in patients with non-resectable early stage hepatocellular carcinoma (HCC) in liver cirrhosis.Currently,patient selection for LT is strictly based on tumor size and number,provided by the Milan criteria.This may,however,exclude patients with advanced tumor load but favourable biology from a possibly curative treatment option.It became clear in recent years that biological tumor viability rather than tumor macromorphology determines posttransplant outcome.In particular,microvascular invasion and poor grading reflect tumor aggressiveness and promote the risk of tumor relapse.Pretransplant biopsy is not applicable due to tumor heterogeneity and risk of tumor cell seeding.18F-fludeoxyglucose (18F-FDG) positron emission tomography (PET),an established nuclear imaging device in oncology,was demonstrated to non-invasively correlate with unfavorable histopathologic features.Currently,there is an increasing amount of evidence that 18F-FDG-PET is very useful for identifying eligible liver transplant patients with HCC beyond standard criteria but less aggressive tumor properties.In order to safely expand the HCC selection criteria and the pool of eligible liver recipients,tumor evaluation with 18F-FDG-PETshould be implemented in pretransplant decision process.

关键词： Hepatocellular carcinoma Liver transplantation 18F-fludeoxyglucose positron emission tomography tumor biology tumor recurrence

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Impact of direct-acting antivirals on the recurrence of hepatocellular carcinoma in chronic hepatitis C

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Hepatoma Research 2022年第1期8卷 327-339页

作者： Nikoletta M.Tagkou Nicolas Goossens Francesco Negro Division of Gastroenterology and Hepatology Geneva University HospitalsGeneva 1211Switzerland Division of Clinical Pathology Geneva University HospitalsGeneva 1211Switzerland

Chronic hepatitis C virus(HCV)infection is estimated to affect 56.8 million individuals globally and is a major and independent risk factor for the development of hepatocellular carcinoma(HCC).After the introduction of safe and potent direct-acting antivirals(DAAs),capable of curing HCV infection also in patients with advanced liver disease at high risk of HCC,the beneficial effect on a de novo HCC development after viral clearance has been established.However,studies addressing the relationship between DAA-induced eradication and risk of HCC recurrence(i.e.,reappearance of HCC treated before starting antivirals)have produced contradictory data,suggesting either an increase or a decrease of HCC recurrence rate,while some report no effect of these treatments.Thus,there seems to be an unclear benefit of viral clearance in patients with a history of HCC curative treatment,where the recurrence rate remains worryingly high.This short review aims to summarize current evidence on the impact of DAAs on HCC recurrence rates,the pathogenic mechanisms and characteristics of HCC recurrence after DAA treatment,the predictors of tumor recurrence,and the impact of DAAs on overall survival.

关键词： Hepatitis C virus hepatocellular carcinoma liver oncogenesis direct-acting antivirals tumor recurrence

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Risk factors for hepatocellular carcinoma recurrence after liver transplantation

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Hepatoma Research 2020年第8期6卷 46-66页

作者： Pierluigi Toniutto Ezio Fornasiere Elisa Fumolo Davide Bitetto Hepatology and Liver Transplantation Unit Azienda Sanitaria Universitaria IntegrataUdine 33100Italy

Liver transplantation(LT)provides an excellent option for the long-term survival of patients with unresectable hepatocellular carcinoma(HCC)based on the Milan criteria.Despite careful selection of patients,HCC may still recur after LT,which represents the most important negative predictor of post-transplant survival.The growing demand for LT in HCC has led to the expansion of patient selection criteria,with a resultant increase in the risk of post-transplant HCC recurrence.Numerous tumor and host factors predict HCC recurrence.The morphological,histological,and serological characteristics of tumors in predicting HCC recurrence have been extensively studied.Furthermore,the type and duration of anticancer response before LT has also been considered a surrogate marker of tumor aggressiveness and is associated with the risk of recurrence.The demographic and clinical characteristics of recipients,as well as the type and duration of exposure to immunosuppressive therapy,represent the main host-related risk factors.Many studies have attempted to describe predictive models for the risk of HCC recurrence,considering evaluable parameters both before and after LT.Although many models have been proposed,relatively few have been externally validated on different patient populations.This paper aims to comprehensively summarize the available data on the predictive factors of HCC recurrence after LT,and to examine and discuss those that have been externally validated.

关键词： Liver transplantation hepatocellular carcinoma tumor recurrence risk predictive model

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Large Medial Sphenoid Wing Meningiomas: long-term outcome and correlation with tumor size after microsurgical in 127 consecutive cases

Large Medial Sphenoid Wing Meningiomas: long-term outcome an...

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2011中华医学会神经外科学学术会议

作者： Dingyang Liu1 Xianrui Yuan1 Qing Liu1 Xinjun Jiang1 Weixi Jiang1 Zefeng Peng1 Xiping Ding1 Duanwu Luo1 1.Department of Neurosurgery, Xiangya Hospital, Central South University, 8 7 Xiangya Road, Changsha, Hunan 4 1 0008 , China

Objective We present the long-term outcomes as well as their correlation with tumor size in 127 consecutive patients harboring large medial sphenoid wing meningiomas (MSWM) after microsurgical treatment.Methods The re... 详细信息

关键词： medial sphenoid wing meningiomas tumor size tumor recurrence functional outcome.

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Oncological safety of submental island flap for reconstruction of pathologically node-negative and node-positive T1–2 oral squamous cell carcinoma-related defects

Oncological safety of submental island flap for reconstructi...

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2020年全国口腔颌面-头颈肿瘤学术大会暨中华口腔医学...

作者：李军上海交通大学医学院附属第九人民医院口腔颌面头颈肿瘤科

Purpose/Background:To evaluate the oncological safety and reliability of the submental island flap(SIF) technique in patients with pathologically node-negative(pN0) and node-positive(pN+) T1–2 oral squamous cell carcinoma(OSCC) undergoing surgical tumor resection and concurrent SIF reconstruction. Materials and Methods: Retrospectively, we reviewed patients with pN0 and pN+ T1–2 OSCC who underwent tumor resection and defect reconstruction with SIF from April 2008 to September 2016,

关键词： Oral squamous cell carcinoma Head and neck cancer tumor recurrence Submental island flap Lymph nodes metastasis Outcome study Locoregional flap Reconstruction

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