18F-FDG-PET for Assessing Biological Viability and Prognosis in Liver Transplant Patients with Hepatocellular Carcinoma
18F-FDG-PET for Assessing Biological Viability and Prognosis in Liver Transplant Patients with Hepatocellular Carcinoma作者机构：Department of Surgery Klinikum rechts der Isar Technical University Munich Germany
出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)
年 卷 期：2017年第5卷第3期
页 面：224-234页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Hepatocellular carcinoma Liver transplantation 18F-fludeoxyglucose positron emission tomography Tumor biology Tumor recurrence
摘 要：Liver transplantation (LT) has become standard of care in patients with non-resectable early stage hepatocellular carcinoma (HCC) in liver ***,patient selection for LT is strictly based on tumor size and number,provided by the Milan *** may,however,exclude patients with advanced tumor load but favourable biology from a possibly curative treatment *** became clear in recent years that biological tumor viability rather than tumor macromorphology determines posttransplant *** particular,microvascular invasion and poor grading reflect tumor aggressiveness and promote the risk of tumor *** biopsy is not applicable due to tumor heterogeneity and risk of tumor cell seeding.18F-fludeoxyglucose (18F-FDG) positron emission tomography (PET),an established nuclear imaging device in oncology,was demonstrated to non-invasively correlate with unfavorable histopathologic ***,there is an increasing amount of evidence that 18F-FDG-PET is very useful for identifying eligible liver transplant patients with HCC beyond standard criteria but less aggressive tumor *** order to safely expand the HCC selection criteria and the pool of eligible liver recipients,tumor evaluation with 18F-FDG-PETshould be implemented in pretransplant decision process.
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