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The 150 most important questions in cancer research and clinical oncology series: questions 94-101

Cancer Communications 2018年第1期38卷 736-744页

作者： Cancer Communications Sun Yat-sen University Cancer Center Guangzhou 510060P.R.China

Since the beginning of 2017,Cancer Communications(former title:Chinese Journal of Cancer)has published a series of important questions regarding cancer research and clinical oncology,to provide an enhanced stimulus for can-cer research,and to accelerate collaborations between institutions and *** this edition,the following 8 valuable questions are *** *** origin of tumors:time for a new paradigm?Question *** can we accelerate the identification of biomarkers for the early detection of pancreatic ductal adenocarcinoma?Question *** we improve the treatment outcomes of metastatic pancreatic ductal adenocarcinoma through precision medicine guided by a combination of the genetic and proteomic information of the tumor?Question *** are the parameters that determine a competent immune system that gives a complete response to cancers after immune induction?Question *** high local concentration of metformin essential for its anti-cancer activity?Question *** can we monitor the emergence of cancer cells anywhere in the body through plasma testing?Question *** phytochemicals be more specific and efficient at targeting P-glycoproteins to overcome multi-drug resistance in cancer cells?Question *** cell migration a selectable trait in the natural evolution of carcinoma?

关键词： tumor origin Polyploid giant cancer cell Pancreatic ductal adenocarcinoma Biomarker Liquid biopsy Spontaneous animal model Metastasis Chemotherapy Immunotherapy Precision treatment Vaccine immunization Metformin Circulating tumor cell Circulating tumor DNA CpG methylation Methylation haplotype block Phytochemicals P-Glycoprotein Multi-drug resistance P-Glycoprotein inhibitor Epithelial-to-mesenchymal transition Migration Pro-migratory gene

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Histological origin of pseudomyxoma peritonei in Chinese women:Clinicopathology and

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World Journal of Gastroenterology 2011年第30期17卷 3531-3537页

作者： Ai-Tao Guo Xin Song Li-Xin Wei Po Zhao Department of Pathology The General Hospital of PLA 100853 Beijing China

AIM： To investigate the myxoma peritonei （PMP） histological origin of pseudo- n Chinese women. METHODS： The clinical and pathological data were reviewed for 35 women with PMP, and specimens of the peritoneal, appendiceal and ovarian lesions of each patient were examined using the PV-6000 immunohistochemistry method. Antibodies included cytokeratin （CK）7, CK20, mucin （MUC）-1, MUC-2, carbohydrate antigen （CA）-125, estrogen receptor （ER）, and progesterone receptor （PR）. RESULTS： Abundant colloidal mucinous tumors were observed in the peritoneum in all 35 cases. Thirty-one patients had a history of appendectomy, 28 of whom had mucinous lesions. There was one patient with appendicitis, one whose appendix showed no apparent pathological changes, and one with unknown surgical pathology. Ovarian mucinous tumors were found in 24 patients. The tumors were bilateral in 13 patients, on the right-side in nine, and on the left side in two. Twenty patients had combined appendiceal and ovarian lesions; 16 of whom had undergone initial surgery for appendiceal lesions. Four patients had undergone initial surgery for ovarian lesions, and relapse occurred in these patients at 1, 11, 32 and 85 mo after initial surgery. Appendi-ceal mucinous tumors were found in each of these four patients. Thirty-three of the 35 patients showed peritoneal lesions that were positive for CK20 and MUC-2, but negative for CK7, MUC-1, CA125, ER and PR. The expression patterns in the appendix and the ovary were similar to those of the peritoneal lesions. In one of the remaining two cases, CK20, CK7 and MUC-2 were positive, and MUC-1, CA125, ER and PR were negative. The ovaries were not resected. The appendix of one patient was removed at another hospital, and no specimen was evaluated. In the other case, the appendix appeared to be normal during surgery, and was not resected. Peritoneal and ovarian lesions were negative for CK20, MUC-2, CK7, MUC-1, CA125, ER and PR. CONCLUSION： Most PMP originated from the ap

关键词： Pseudomyxoma peritonei Peritoneum tumor origin Ovary Appendix Immunohistochemistry

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Phenotypic Characterization Murine Sarcoma TG-180 Immunophenotypical Characterization Murine Sarcoma TG-180

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Open Journal of Pathology 2015年第2期5卷 59-64页

作者： Thais M.T.Bernardes Hugo E.O.Beserra Stephane C.O.R.Vexenat Helio Langoni Noeme S.Rocha Department of Clinical Veterinary Medicine Laboratory of Investigative and Comparative PathologySchool of Veterinary Medicine and Animal ScienceSao Paulo State UniversityBotucatuBrazil Department of Veterinary Hygiene and Public Health School of Veterinary Medicine and Animal ScienceSao Paulo State UniversityBotucatuBrazil

The sarcoma is the generic nomenclature for neoplasm of mesodermal cells, which express in man and animals. Silent growth requires early diagnosis technique for identifying their proteins. The experimental model in vivo murine sarcoma 180-TG (TG-180), is widely used in research to provide the stimuli of infectious and neoplastic antigens. In this case, the technique of immunohisto-chemistry helps identify the expressions of tumor cell variants. The objective of the research was to characterize immunoexpression murine sarcoma TG 180, by immunohistochemistry, antibodies AE1/AE3, vimentin, CD3, CD 45, CD79α and S100A4. For this, murine sarcoma TG-180, was implanted subcutaneously in 20 mice “Swiss”, male, 30 days old, 28 g for 10 days. Samples were taken and subjected to immunohistochemistry, via use of HistoMouse-MA™? kit. There was specifically labeled S100A4 and vimentin antibodies, indicative of poorly differentiated neoplasms fibroblasts. In fact, the model is established by identifying the origin of the cell, once identified, chemotherapeutic tests can also be performed. Neoplasia like these, when installed in man and animals, depending on the degree of aggressiveness requires treatment protocol varied between surgery and chemotherapy or combination of treatments.

关键词： Immunohistochemistry Neoplasia Mice tumor origin

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