The 150 most important questions in cancer research and clinical oncology series: questions 94-101
作者机构：Sun Yat-sen University Cancer CenterGuangzhou 510060P.R.China
出 版 物：《Cancer Communications》 (癌症通讯（英文）)
年 卷 期：2018年第38卷第1期
页 面：736-744页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Tumor origin Polyploid giant cancer cell Pancreatic ductal adenocarcinoma Biomarker Liquid biopsy Spontaneous animal model Metastasis Chemotherapy Immunotherapy Precision treatment Vaccine immunization Metformin Circulating tumor cell Circulating tumor DNA CpG methylation Methylation haplotype block Phytochemicals P-Glycoprotein Multi-drug resistance P-Glycoprotein inhibitor Epithelial-to-mesenchymal transition Migration Pro-migratory gene
摘 要：Since the beginning of 2017,Cancer Communications(former title:Chinese Journal of Cancer)has published a series of important questions regarding cancer research and clinical oncology,to provide an enhanced stimulus for can-cer research,and to accelerate collaborations between institutions and *** this edition,the following 8 valuable questions are *** *** origin of tumors:time for a new paradigm?Question *** can we accelerate the identification of biomarkers for the early detection of pancreatic ductal adenocarcinoma?Question *** we improve the treatment outcomes of metastatic pancreatic ductal adenocarcinoma through precision medicine guided by a combination of the genetic and proteomic information of the tumor?Question *** are the parameters that determine a competent immune system that gives a complete response to cancers after immune induction?Question *** high local concentration of metformin essential for its anti-cancer activity?Question *** can we monitor the emergence of cancer cells anywhere in the body through plasma testing?Question *** phytochemicals be more specific and efficient at targeting P-glycoproteins to overcome multi-drug resistance in cancer cells?Question *** cell migration a selectable trait in the natural evolution of carcinoma?
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