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A Novel Therapy of eosinophilic esophagitis-treatment of eosinophilic esophagitis Using a Single Dose of Intramuscular Corticosteroid and Proton Pump Inhibitor

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Journal of Pharmacy and Pharmacology 2017年第11期5卷 834-839页

作者： Augusto Fey Lorete Maria da Silva Kotze Monica Serapiao Faculty of Medicine UNIDA VI Rio do Sul89160-932 Brazil Department of Health Sciences Pontifical Catholic University Curitiba 80215-901 Brazil

Background： Ee （eosinophilic esophagitis） is an inflammatory condition characterized by a dense eosinophilic infiltrate in the esophageal epithelium. Its pathophysiology mimics that of allergic esophagitis, and evolves clinically as a chronic disease with periods of exacerbation. Symptoms and endoscopic findings are usually non-specific and similar to those of other esophageal illnesses. The mainstay of treatment of Ee is with corticosteroids and/or specific diets, which have been shown to cause symptom remission and histological improvement. Aim： The objective of this study was to demonstrate the efficacy of a novel and promising treatment protocol for Ee. Materials and methods： We prospectively evaluated 24 patients with Ee over two years. Patients were treated with a single intramuscular injection of betamethasone sodium phosphate associated with betamethasone dipropionate and a PPI （proton pump inhibitor）（rabeprazole 20 mg PO）. After 4 weeks of treatment, patients underwent endoscopy and biopsy. We evaluated patients＇ clinical response as well as the results of endoscopic and histological examinations. Results： After 4 weeks of treatment, all patients （100%） are reported significant clinical improvement, which was corroborated by the findings on endoscopy and histology. There were no complications or adverse reactions. Conclusions： In this cohort of patients with eosinophilic esophagitis, treatment with a single intramuscular dose of corticosteroids led to complete remission of symptoms and improvement in endoscopic and histological findings.

关键词： treatment of eosinophilic esophagitis corticotherapy corticosteroid eosinophil Ee.

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