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treatment strategies for nodal and gastrointestinal follicular lymphoma:Current status and future development

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World Journal of Gastroenterology 2010年第44期16卷 5543-5554页

作者： Takuya Watanabe Department of Internal Medicine and Gastroenterology Medical HospitalThe Nippon Dental University School of Life Dentistry at Niigata

In recent years,therapies for follicular lymphoma (FL) have steadily improved.A series of phase Ⅲ trials comparing the effect of rituximab with chemotherapy vs chemotherapy alone in treating FL have indicated significant improvements in progression-free survival (PFS) and overall *** studies have found that prolonged response durations and PFS were obtained with maintenance therapy using rituximab or interferon after completion of first line *** patients with relapsed or refractory FL,phase Ⅱ studies have assessed the effectiveness of combination therapies using a Toll-like receptor-9 agonist (1018ISS),oblimersen sodium (a Bcl-2 antisense oligonucleotide),bendamustine,and rituximab,as well as veltuzumab,a new humanized anti-CD20 antibody,and *** addition,the effectiveness of yttrium-90 ibritumomab tiuxetan and iodine-131 tositumomab as radioimmunotherapies has been ***,three phase Ⅲ studies on an idiotype vaccine are near ***,these vaccines,which appeared highly effective in phase Ⅰ and Ⅱ trials,do not appear to result in prolonged *** report will summarize the current knowledge on therapies for treatment of FL,and will conclude with a brief discussion of feasiblefuture options for effective ***,we added descriptions of the management of gastrointestinal FL,which is considered to be controversial because it is rare.

关键词： Anti-CD20 monoclonal antibody (rituximab) Follicular lymphoma Idiotype vaccines Immunoradiotherapy treatment strategies

Advances in diagnosis and treatment strategies of thymic carcinoid

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转化医学电子杂志 2017年第5期4卷 55-60页

作者：赵珞 ZHU Rong-Rong LIANG Nai-Xin LI Shan-Qing Department of Thoracic Surgery Peking Union Medical College HospitalChinese Academy of Medical Science

Thymic carcinoid is a rare neuroendocrine tumor with unclear risk factors and controversial classifications. Its clinical manifestations vary from asymptomatic to many nonspecific symptoms,among which endocrine abnormality seems to be associated with poor prognosis. Quantitative and qualitative analysis of ACTH and prognosis could become a topic in the future. Image studies show no specificity both in CT and PET/CT,but are of great value in clinical staging of thymic carcinoid. Ki67 has been found to be a powerful tool for grading neuroendocrine tumors and further studies should be made. The diagnosis of thymic carcinoid mainly depends on pathology and immunohistochemistry plays a key role in differential diagnosis at present. Radical resection is the first choice in treatment,and target therapy becomes possible with the development in molecular pathology. However,since the rarity of thymic carcinoid,there is no practical clinical staging or standard guideline to instruct clinical practice. Thus,support of International Thymic Malignancy Interest Group( ITMIG) seems to be of great significance in case collection and resource sharing of thymic diseases. In this paper,we are going to put forward a strategy available in clinical application for diagnoisis and treatment of thymic carcinoid by using a new clinical staging system.

关键词： thymic carcinoid clinical staging treatment strategies Ki67

Advances in treatment strategies for COVID-19:Insights from other coronavirus diseases and prospects

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Biosafety and Health 2023年第5期5卷 272-279页

作者： Yingwen Li Jiaming Lan Gary Wong Viral Hemorrhagic Fevers Research Unit C.A.S.Key Laboratory of Molecular Virology and ImmunologyInstitut Pasteur of ShanghaiChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China

The coronavirus disease 2019(COVID‐19)pandemic is the third human disease outbreak caused by an emerging coronavirus in the 21st *** by severe acute respiratory syndrome coronavirus 2(SARS‐CoV‐2),the COVID‐19 pandemic has been the most devastating,with millions of *** countermeasures are needed to limit the number of infections and ***,we discuss advances in clinical and research‐based treatment methods for SARS‐CoV‐2 that were initially derived from treatments for other *** advances in SARS‐CoV‐2 treatments,from traditional drugs and immunotherapies to artificial intelligence to predict potential future treatment methods,are summarized and discussed.

关键词： SARS‐CoV‐2 COVID‐19 treatment strategies Potential treatments

Analysis of treatment strategies of traditional Chinese medicine for COVID-19 in tropical regions based on the pathogens of dampness and heat

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Journal of Hainan Medical University 2020年第9期26卷 10-14页

作者： Xian Wang Wen-Long Zhang Chang Liu Mi Li Kai Li Yi-Qiang Xie School of Traditional Chinese Medicine Hainan Medical UniversityHaikou 571199China

Objective:To summarize the treatment strategies of Traditional Chinese Medicine(TCM)for COVID-19 in tropical regions based on the pathogens of dampness and ***:For heat pathogen,analyzing heat in the superficies,lung and Yang Ming based on the different *** on the progress of the disease,analyzing the stage of toxin and Qi deficiency induced by *** dampness pathogen,analyzing endogenous and external dampness based on the different *** dampness pathogen's special disease location—Moyuan and special symptom of dry cough with less sputum caused by sticky and stagnant characteristic of ***:The treatment strategies for heat and dampness pathogen were ***:In the tropics,the pathogens of dampness and heat occur frequently and clinical treatments need to be dialectical.

关键词： Pathogens of dampness and heat Tropics COVID-19 TCM treatment strategies

Lipid metabolism, amino acid metabolism, and prostate cancer: a crucial metabolic journey

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Asian Journal of Andrology 2024年第2期26卷 123-134页

作者： Lin Chen Yu-Xin Xu Yuan-Shuo Wang Jian-Liang Zhou School of Pharmacy Hangzhou Normal UniversityHangzhou 311121China Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province Hangzhou Normal UniversityHangzhou 311121China School of Pharmacy Guangxi Medical UniversityNanning530021China

Prostate cancer(PCa)is one of the most common malignancies in males worldwide,and its development and progression involve the regulation of multiple metabolic *** in lipid metabolism affect the proliferation and metastatic capabilities of PCa *** cells increase lipid synthesis and regulate fatty acid oxidation to meet their growth and energy ***,changes occur in amino acid metabolism in *** cells exhibit an increased demand for specific amino acids,and they regulate amino acid transport and metabolic pathways to fulfill their proliferation and survival *** changes are closely associated with disease progression and treatment response in PCa ***,a comprehensive investigation of the metabolic characteristics of PCa is expected to offer novel insights and approaches for the early diagnosis and treatment of this disease.

关键词： amino acid metabolism lipid metabolism metabolic pathways prostate cancer treatment strategies

The current role of dendritic cells in the progression and treatment of colorectal cancer

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Cancer Biology & Medicine 2024年第9期21卷 769-783页

作者： Yuanci Zhang Songtao Ji Ge Miao Shuya Dul Haojia Wang Xiaohua Yang Ang Li Yuanyuan Lu Xin Wang Xiaodi Zhao State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers National Clinical Research Center for Digestive DiseasesXijing HospitalFourth Military Medical UniversityXi'an 710032China Department of Gastroenterology Tangdu HospitalFourth Military Medical UniversityXi'an 710038China Department of Experimental Surgery Xijing HospitalFourth Military Medical UniversityXi'an 710032China Department of Gastroenterology the 988th Hospital of PLA Joint Logistics Support ForceZhengzhou 450042China

Colorectal cancer(CRC)is the third most common cancer and the second leading cause of cancer-related deaths *** cells(DCs)constitute a heterogeneous group of antigen-presenting cells that are important for initiating and regulating both innate and adaptive immune *** a crucial component of the immune system,DCs have a pivotal role in the pathogenesis and clinical treatment of *** cross-present tumor-related antigens to activate T cells and trigger an antitumor immune ***,the antitumor immune function of DCs is impaired and immune tolerance is promoted due to the presence of the tumor *** review systematically elucidates the specific characteristics and functions of different DC subsets,as well as the role that DCs play in the immune response and tolerance within the CRC ***,how DCs contribute to the progression of CRC and potential therapies to enhance antitumor immunity on the basis of existing data are also discussed,which will provide new perspectives and approaches for immunotherapy in patients with CRC.

关键词： Colorectal cancer dendritic cells tumor progression treatment strategies

Alcoholic Liver Disease in China:A Disease Influenced by Complex Social Factors That Should Not Be Neglected

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Journal of Clinical and Translational Hepatology 2024年第7期12卷 677-684页

作者： Xiaofeng Feng Nafei Huang Yuqin Wu Fei Gao Xiaomei Chen Chenyi Zhang Bing Zhang Tao Sun The Second Clinical Medical College of Zhejiang Chinese Medical University HangzhouZhejiangChina The Second Affiliated Hospital of Zhejiang Chinese Medical University HangzhouZhejiangChina Hangzhou First People’s Hospital HangzhouZhejiangChina

Alcoholic liver disease(ALD)encompasses liver damage caused by chronic,excessive alcohol *** manifests initially as marked hepatocellular steatosis and can progress to steatohepatitis,liver fibrosis,and *** China’s rapid economic growth,coupled with a complex social background and the influence of a deleterious wine culture,the number of patients with ALD in China has increased significantly;the disease has become a social and health problem that cannot be *** this review,we briefly described the social factors affecting ALD in China and elaborated on differences between alcoholic and other liver diseases in terms of complications(e.g.,cirrhosis,upper gastrointestinal bleeding,hepatic encephalopathy,hepatocellular carcinoma,addiction,and other extrahepatic diseases).We also emphasized that ALD was more dangerous and difficult to treat than other liver diseases due to its complications,and that precise and effective treatment measures were *** addition,we considered new ideas and treatment methods that may be generated in the future.

关键词： Alcoholic liver disease Wine culture Complication Epidemiology treatment strategies Comparison

Drug resistance mechanisms in cancers:Execution of prosurvival strategies

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Journal of Biomedical Research 2024年第2期38卷 95-121页

作者： Pavan Kumar Dhanyamraju Fels Cancer Institute of Personalized Medicine Lewis-Katz School of MedicineTemple UniversityPhiladelphiaPA 19140USA

One of the quintessential challenges in cancer treatment is drug *** mechanisms of drug resistance have been described to date,and new modes of drug resistance continue to be *** phenomenon of cancer drug resistance is now widespread,with approximately 90% of cancer-related deaths associated with drug *** significant advances in the drug discovery process,the emergence of innate and acquired mechanisms of drug resistance has impeded the progress in cancer ***,understanding the mechanisms of drug resistance and the various pathways involved is integral to treatment *** the present review,I discuss the different mechanisms of drug resistance in cancer cells,including DNA damage repair,epithelial to mesenchymal transition,inhibition of cell death,alteration of drug targets,inactivation of drugs,deregulation of cellular energetics,immune evasion,tumor-promoting inflammation,genome instability,and other contributing epigenetic ***,I highlight available treatment options and conclude with future directions.

关键词： cancer drug resistance mechanisms microRNAs treatment strategies

Hepatitis B cure:Current situation and prospects

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World Journal of Hepatology 2024年第6期16卷 900-911页

作者： Ya-Ping Li Chen-Rui Liu Ling He Shuang-Suo Dang Department of Infectious Diseases The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina

Achievement of a‘clinical cure’in chronic hepatitis B(CHB)implies sustained virological suppression and immunological control over the infection,which is the ideal treatment goal according to domestic and international CHB management *** practice has shown encouraging results for specific patient cohorts using tailored treatment *** regimens incorporate either nucleos(t)ide analogs,immunomodulatory agents such as pegylated interferonα,or a strategic combination of both,sequentially or concurrently *** these advancements in the clinical handling of hepatitis B,achieving a clinical cure remains elusive for a considerable subset of patients due to the number of challenges that preclude the realization of optimal treatment *** include,but are not limited to,the emergence of antiviral resistance,incomplete immune recovery,and the persistence of covalently closed circular ***,the variance in response to interferon therapy and the lack of definitive biomarkers for treatment cessation also contribute to the complexity of achieving a clinical *** article briefly overviews the current research progress and existing issues in pursuing a clinical cure for hepatitis B.

关键词： Chronic hepatitis B Clinical cure Polyethylene glycol interferon treatment strategies Research progress