The current role of dendritic cells in the progression and treatment of colorectal cancer

作     者：Yuanci Zhang Songtao Ji Ge Miao Shuya Du Haojia Wang Xiaohua Yang Ang Li Yuanyuan Lu Xin Wang Xiaodi Zhao Yuanci Zhang;Songtao Ji;Ge Miao;Shuya Du;Haojia Wang;Xiaohua Yang;Ang Li;Yuanyuan Lu;Xin Wang;Xiaodi Zhao

作者机构：State Key Laboratory of Holistic Integrative Management of Gastrointestinal CancersNational Clinical Research Center for Digestive DiseasesXijing HospitalFourth Military Medical UniversityXi'an 710032China Department of GastroenterologyTangdu HospitalFourth Military Medical UniversityXi'an 710038China Department of Experimental SurgeryXijing HospitalFourth Military Medical UniversityXi'an 710032China Department of Gastroenterologythe 988th Hospital of PLA Joint Logistics Support ForceZhengzhou 450042China 

出 版 物：《Cancer Biology & Medicine》 (癌症生物学与医学（英文版）)

年 卷 期：2024年第21卷第9期

页      面：769-783页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This study was supported by grants from the National Natural Science Foundation of China(Grant Nos.82222058 82073197 82273142 and 82173256) 

主　　题：Colorectal cancer dendritic cells tumor progression treatment strategies 

摘      要：Colorectal cancer(CRC)is the third most common cancer and the second leading cause of cancer-related deaths *** cells(DCs)constitute a heterogeneous group of antigen-presenting cells that are important for initiating and regulating both innate and adaptive immune *** a crucial component of the immune system,DCs have a pivotal role in the pathogenesis and clinical treatment of *** cross-present tumor-related antigens to activate T cells and trigger an antitumor immune ***,the antitumor immune function of DCs is impaired and immune tolerance is promoted due to the presence of the tumor *** review systematically elucidates the specific characteristics and functions of different DC subsets,as well as the role that DCs play in the immune response and tolerance within the CRC ***,how DCs contribute to the progression of CRC and potential therapies to enhance antitumor immunity on the basis of existing data are also discussed,which will provide new perspectives and approaches for immunotherapy in patients with CRC.