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Roles of transforming growth factor-βsignaling in liver disease

World Journal of Hepatology 2024年第7期16卷 973-979页

作者： Xiao-Ling Wang Meng Yang Ying Wang Clinical Laboratory Shanxi Academy of Traditional Chinese MedicineTaiyuan 030012Shanxi ProvinceChina

In this editorial we expand the discussion on the article by Zhang et al published in the recent issue of the World Journal of *** focus on the diagnostic and therapeutic targets identified on the basis of the current understanding of the molecular mechanisms of liver *** growth factor-β(TGF-β)belongs to a structurally related cytokine super *** family members display different time-and tissue-specific expression patterns associated with autoimmunity,inflammation,fibrosis,and tumorigenesis;and,they participate in the pathogenesis of many ***-βand its related signaling pathways have been shown to participate in the progression of liver diseases,such as injury,inflammation,fibrosis,cirrhosis,and *** often studied TGF-β/Smad signaling pathway has been shown to promote or inhibit liver fibrosis under different ***,the early immature TGF-βmolecule functions as a tumor suppressor,inducing apoptosis;but,its interaction with the mitogenic molecule epidermal growth factor alters this effect,activating anti-apoptotic signals that promote liver cancer ***,TGF-βsignaling displays contradictory effects in different liver disease ***,the use of TGF-βand related signaling pathway molecules for diagnosis and treatment of liver diseases remains a challenge and needs further *** this editorial,we aim to review the evidence for the use of TGF-βsignaling pathway molecules as diagnostic or therapeutic targets for different liver disease stages.

关键词： transforming growth factor-βsignaling Liver disease Molecular mechanism Targets Diagnosis

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Identification of WWTR1 as an immune infiltration-correlated prognostic biomarker in colon cancer

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Medical Data Mining 2022年第2期5卷 43-53页

作者： Jian-Shun Ge Jie Zhang Rui Wang Hai-Ning Li Xin-Nong Liu Xu-Dong Yin Yan-Bing Ding Guo-Tao Lu Lin-Lin Tian Institute of Digestive Diseases The Affiliated Hospital of Yangzhou UniversityYangzhou 225000China Department of General Surgery The Affiliated Hospital of Yangzhou UniversityYangzhou 225000China Department of Oncology The Affiliated Hospital of Yangzhou UniversityYangzhou 225000China Department of Gastroenterology The Affiliated Hospital of Yangzhou UniversityYangzhou 225000China Department of Oncology Dalian Medical UniversityDalian 116044China

WWTR1,a gene related to the TGF-βsignaling pathway,has been elucidated to be involved in oncogenesis in multiple *** is,however,no research on its link to immune infiltration in colon *** TCGA database has identified WWTR1,a gene related to the TGF-βsignaling pathway,which is lowly expressed in colon cancer patients compared to normal ***,we produced the Kapan-Meier curve with GEO and the TCGA database,which revealed that colon cancer patients with high WWTR1 expression had a poor *** discovered that high expression of WWTR1 in colon cancer was associated with clinical stage,pathological T-stage,and lymphatic metastasis after examining the clinical characteristics of colon cancer ***1 was found to be an independent predictive factor for colon cancer in a multivariate Cox regression *** of immunological cells(B cells,CD8^(+)T cells,CD4^(+)T cells,Macrophage,Neutrophil,Dendritic cells)was linked to WWTR1 *** colon cancer,WWTR1 expression was also found to be favorably linked with major immune cell *** to an analysis of WWTR1 DCGs,GO,and KEGG enrichment analysis,WWTR1 expression levels were associated with ameboidal-type cell migration,focal adhesion,actin binding,Chemical carcinogenesis-reactive oxygen species,Non-alcoholic fatty liver disease,and Alzheimer *** findings imply that WWTR1 is a prognostically valuable and important biomarker for colon cancer,and imply that its expression is strongly linked to colon cancer immune infiltration,making it a potential new target for colon cancer biotherapy.

关键词： WWTR1 colon cancer The Cancer Genome Atlas transforming growth factor-βsignaling immune infiltration prognosis

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