Roles of transforming growth factor-βsignaling in liver disease

作     者：Xiao-Ling Wang Meng Yang Ying Wang 

作者机构：Clinical LaboratoryShanxi Academy of Traditional Chinese MedicineTaiyuan 030012Shanxi ProvinceChina 

出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)

年 卷 期：2024年第16卷第7期

页      面：973-979页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by Shanxi Provincial Health Commission Youth Research Project,No.2021081 Traditional Chinese Medicine Administration of Shanxi Province,No.2023ZYYDA2001 

主　　题：Transforming growth factor-βsignaling Liver disease Molecular mechanism Targets Diagnosis 

摘      要：In this editorial we expand the discussion on the article by Zhang et al published in the recent issue of the World Journal of *** focus on the diagnostic and therapeutic targets identified on the basis of the current understanding of the molecular mechanisms of liver *** growth factor-β(TGF-β)belongs to a structurally related cytokine super *** family members display different time-and tissue-specific expression patterns associated with autoimmunity,inflammation,fibrosis,and tumorigenesis;and,they participate in the pathogenesis of many ***-βand its related signaling pathways have been shown to participate in the progression of liver diseases,such as injury,inflammation,fibrosis,cirrhosis,and *** often studied TGF-β/Smad signaling pathway has been shown to promote or inhibit liver fibrosis under different ***,the early immature TGF-βmolecule functions as a tumor suppressor,inducing apoptosis;but,its interaction with the mitogenic molecule epidermal growth factor alters this effect,activating anti-apoptotic signals that promote liver cancer ***,TGF-βsignaling displays contradictory effects in different liver disease ***,the use of TGF-βand related signaling pathway molecules for diagnosis and treatment of liver diseases remains a challenge and needs further *** this editorial,we aim to review the evidence for the use of TGF-βsignaling pathway molecules as diagnostic or therapeutic targets for different liver disease stages.