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Rapidly separating dissolving microneedles with sustained-release colchicine and stabilized uricase for simplified long-term gout management

引用

Acta Pharmaceutica Sinica B 2023年第8期13卷 3454-3470页

作者： Yao Yang Zimu Li Ping Huang Jiachan Lin Jinyuan Li Kexin Shi Jiahui Lin Jingwen Hu Zhuoxian Zhao Yongkang Yu Hongzhong Chen Xiaowei Zeng Lin Mei Institute of Pharmaceutics School of Pharmaceutical Sciences(Shenzhen)Sun Yat-sen UniversityShenzhen 518107China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yatsen University Cancer CenterGuangzhou 510060China Tianjin Key Laboratory of Biomedical Materials Key Laboratory of Biomaterials and Nanotechnology for Cancer ImmunotherapyInstitute of Biomedical EngineeringChinese Academy of Medical SciencesPeking Union Medical CollegeTianjin300192China

Despite growing prevalence and incidence,the management of gout remains *** intermittent nature of the gout makes the long-term urate-lowering therapy(ULT)particularly important for gout ***,patients are reluctant to take medication day after day to manage incurable occasional gout flares,and suffer from possible long-term ***,a safe and easy-tooperate drug delivery system with simple preparation for the long-term management of gout is very ***,a chitosan-containing sustained-release microneedle system co-loaded with colchicine and uricase liposomes were fabricated to achieve this *** microneedle system was confirmed to successfully deliver the drug to the skin and maintain a one-week drug ***,its powerful therapeutic potency to manage gout was investigated in both acute gouty and chronic gouty ***,the drug co-delivery system could help avoid long-term daily oral colchicine,a drug with a narrow therapeutic *** system also avoids mass injection of uricase by improving its stability,enhancing the clinical application value of *** general,this two-drug system reduces the dosage of uricase and colchicine and improves the patient’s compliance,which has a strong clinical translation.

关键词： Microneedles Colchicine Sustained-release Uricase Liposome transdermal administration Gout management Long-term urate-lowering therapy

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