Rapidly separating dissolving microneedles with sustained-release colchicine and stabilized uricase for simplified long-term gout management

作     者：Yao Yang Zimu Li Ping Huang Jiachan Lin Jinyuan Li Kexin Shi Jiahui Lin Jingwen Hu Zhuoxian Zhao Yongkang Yu Hongzhong Chen Xiaowei Zeng Lin Mei Yao Yang;Zimu Li;Ping Huang;Jiachan Lin;Jinyuan Li;Kexin Shi;Jiahui Lin;Jingwen Hu;Zhuoxian Zhao;Yongkang Yu;Hongzhong Chen;Xiaowei Zeng;Lin Mei

作者机构：Institute of PharmaceuticsSchool of Pharmaceutical Sciences(Shenzhen)Sun Yat-sen UniversityShenzhen 518107China State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yatsen University Cancer CenterGuangzhou 510060China Tianjin Key Laboratory of Biomedical MaterialsKey Laboratory of Biomaterials and Nanotechnology for Cancer ImmunotherapyInstitute of Biomedical EngineeringChinese Academy of Medical SciencesPeking Union Medical CollegeTianjin300192China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2023年第13卷第8期

页      面：3454-3470页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：the financial support from the National Natural Science Foundation(NOs.32071342,and 82272154,China) Guangdong Special Support Program(NO.2019TQ05Y209,China) the Natural Science Foundation of Guangdong Province(NO.2023A1515012015,China) Tianjin Science Fund for Distinguished Young Scholars(NO.22JCJQJC00120,China) Natural Science Foundation of Tianjin(The Basic Research Cooperation Special Foundation of Beijing-Tianjin-Hebei Region,NO.22JCZXJC00060,China) the Fundamental Research Funds for the Central Universities(NO.2021-RC310-005,China) Technology&Innovation Commission of Shenzhen Municipality(NOs.JCYJ20220818102810023,JCYJ20190807153601667,and JCYJ20210324124402006,China) Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(NOs.2021-I2M-1e058,and 2022-I2M-2-003,China) 

主　　题：Microneedles Colchicine Sustained-release Uricase Liposome Transdermal administration Gout management Long-term urate-lowering therapy 

摘      要：Despite growing prevalence and incidence,the management of gout remains *** intermittent nature of the gout makes the long-term urate-lowering therapy(ULT)particularly important for gout ***,patients are reluctant to take medication day after day to manage incurable occasional gout flares,and suffer from possible long-term ***,a safe and easy-tooperate drug delivery system with simple preparation for the long-term management of gout is very ***,a chitosan-containing sustained-release microneedle system co-loaded with colchicine and uricase liposomes were fabricated to achieve this *** microneedle system was confirmed to successfully deliver the drug to the skin and maintain a one-week drug ***,its powerful therapeutic potency to manage gout was investigated in both acute gouty and chronic gouty ***,the drug co-delivery system could help avoid long-term daily oral colchicine,a drug with a narrow therapeutic *** system also avoids mass injection of uricase by improving its stability,enhancing the clinical application value of *** general,this two-drug system reduces the dosage of uricase and colchicine and improves the patient’s compliance,which has a strong clinical translation.