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transcutaneous electroacupuncture alleviates postoperative ileus after gastrectomy: A randomized clinical trial

World Journal of Gastrointestinal Surgery 2018年第2期10卷 13-20页

作者： Kai-Bo Chen Yi-Qiao Lu Jian-De Chen Di-Ke Shi Zhi-Hui Huang Yi-Xiong Zheng Xiao-Li Jin Zhe-Fang Wang Wei-Dong Zhang Yi Huang Zhi-Wei Wu Guo-Ping Zhang Hang Zhang Ying-Hao Jiang Li Chen Department of General Surgery Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Obstetrics and Gynecology Women’s HospitalZhejiang University School of MedicineHangzhou 310006Zhejiang ProvinceChina Division of Gastroenterology and Hepatology Johns Hopkins University School of MedicineBaltimoreMD 21224United States Department of Gastroenterology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016Zhejiang ProvinceChina Department of General Visceral and Cancer SurgeryUniversity of CologneCologne 50937Germany Department of Thyroid Surgery Ningbo No.2 HospitalNingbo 315000Zhejiang ProvinceChina Department of Chinese Medicine Rehabilitation Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of General Surgery First People’s Hospital of WenlingTaizhou 317500Zhejiang ProvinceChina

AIM To investigate the efficacy and safety of transcutaneouselectroacupuncture(TEA) to alleviate postoperative ileus(POI) after *** From April 2014 to February 2017, 63 gastric cancer patients were recruited from the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. After gastrectomy, the patients were randomly allocated to the TEA(n = 33) or control(n = 30) group. The patients in the TEA group received 1 h TEA on Neiguan(ST36) and Zusanli(PC6) twice daily in the morning and afternoon until they passed flatus. The main outcomes were hours to the first flatus or bowel movement, time to nasogastric tube removal, time to liquid and semi-liquid diet, and hospital stay. The secondary outcomes included postoperative symptom assessment and *** Time to first flatus in the TEA group was significantly shorter than in the control group(73.19 ± 15.61 vs 82.82 ± 20.25 h, P = 0.038), especially for open gastrectomy(76.53 ± 14.29 vs 87.23 ± 20.75 h, P = 0.048). Bowel sounds on day 2 in the TEA group were significantly greater than in the control group(2.30 ± 2.61/min vs 1.05 ± 1.26/min, P = 0.017). Time to nasogastric tube removal in the TEA group was earlier than in the control group(4.22 ± 1.01 vs 4.97 ± 1.67 d, P = 0.049), as well as the time to liquid diet(5.0 ± 1.34 vs 5.83 ± 2.10 d, P = 0.039). Hospital stay in the TEA group was significantly shorter than in the control group(8.06 ± 1.75 vs 9.40 ± 3.09 d, P = 0.041). No significant differences in postoperative symptom assessment and complications were found between the groups. There were no severe adverse events related to *** TEA accelerated bowel movements and alleviated POI after open gastrectomy and shortened hospital stay.

关键词： transcutaneous electroacupuncture Gastrectomy Postoperative ileus

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Effect of transcutaneous electrical acupoint stimulation combined with palonosetron on chemotherapy-induced nausea and vomiting: a ***,randomized, controlled trial

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Chinese Journal of Cancer 2017年第5期36卷 213-221页

作者： Jing Xie Lei-Hua Chen Zhou-Yu Ning Chen-Yue Zhang Hao Chen Zhen Chen Zhi-Qiang Meng Xiao-Yan Zhu Department of Integrative Oncology Fudan University Shanghai Cancer Center 270 Dong’An Road Shanghai 200032 P. R. China Department of Oncology Shanghai Medical College Fudan University 270 Dong’An RoadShanghai 200032 P. R. China

Background: Chemotherapy?induced nausea and vomiting adversely affects the quality of life of patients who receive chemotherapy via intravenous infusion or transcatheter arterial chemoembolization(TACE). This study aimed to investigate the clinical effects of transcutaneous electrical acupoint stimulation(TEAS) on nausea and vomiting after ***: A total of 142 patients who received TACE with cisplatin for primary or metastatic liver cancer were assigned to the active?acupuncture(n = 72) or placebo?acupuncture(n Hegu(LI4), Neiguan(P6), an= 70) groups using a covariate?adaptive randomization at a ratio of 1:1. The acupointsd Zusanli(ST36) were stimulated twice daily for 6 days. The effects of TEAS on nausea and vomiting were assessed by using occurrence rate and severity of these symptoms. Anorexia scale and M. D. Anderson Symptom Inventory(MDASI) scores were secondary endpoints and were used to assess the effect of TEAS on patient appetite and quality of life. The safety of the treatments was also ***: Between the two groups, the differences in occurrence rates and severities of nausea and vomiting after TACE were not significant(all P > 0.05). From the second day after TACE, anorexia scores were significantly lower in the active?acupuncture group than in the placebo?acupuncture group and continued to decrease over time with treat?ment(all P values less than 0.01). On days 0, 1, and 2, the mean MDASI scores for the active?acupuncture group were slightly lower than those for the placebo?acupuncture group, but the differences were not statistically significant(all P > 0.05). No significant differences were found between the two groups in the occurrence rate of any adverse event(P > 0.05).Conclusion: TEAS appears to be a safe and effective therapy to relieve patients' gastrointestinal discomfort after chemotherapy.

关键词： Acupuncture Electro-acupuncture transcutaneous electrical acupoint stimulation Nausea Vomiting Anorexia

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Does the advantage of transcutaneous oximetry measurements in diabetic foot ulcer apply equally to free flap reconstruction?

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World Journal of Clinical Cases 2023年第31期11卷 7570-7582页

作者： Da Woon Lee Yong Seon Hwang Je Yeon Byeon Jun Hyuk Kim Hwan Jun Choi Department of Plastic and Reconstructive Surgery College of MedicineSoonchunhyang UniversityCheonan-si 31151South Korea

BACKGROUND transcutaneous oxygen pressure(TcpO2)is a precise method for determining oxygen perfusion in wounded *** device uses either electrochemical or optical *** To evaluate the usefulness of TcpO2 measurements on free flaps(FFs)in diabetic foot ulcers(DFUs).METHODS TcpO2 was measured in 17 patients with DFUs who underwent anterolateral thigh(ALT)-FF surgery and compared with 30 patients with DFU without FF *** Significant differences were observed in the ankle-brachial index;duration of diabetes;and haemoglobin,creatinine,and C-reactive protein levels between the two ***2 values were similar between two groups except on postoperative days 30 and 60 when the values in the ALT-FF group remained50 *** Even if the flap is clinically stable,sympathectomy due to adventitia stripping during anastomosis and arteriovenous shunt progression due to diabetic polyneuropathy could lead to low TcpO2 values in the ALT-FF owing to its thick fat tissues,which is supported by the slow recovery of the sympathetic tone following ***,TcpO2 measurements in patients with DFU who underwent FF reconstruction may be less accurate than in those who did not.

关键词： Arteriovenous shunt Surgical Diabetic neuropathies Free tissue flaps Sympathectomy Blood gas monitoring transcutaneous Diabetic angiopathies

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Effect and mechanism study on transcutaneous auricular vagus nerve stimulation for functional dyspepsia model rats

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World Journal of Acupuncture-Moxibustion 2020年第1期30卷 49-56页

作者： Li-wei HOU Pei-jing RNG Wei WEI Ji-liang FANG Dan WANG Wei-hang ZHAI Yu WANG Jun-ying WANG China Academy of Chinese Medical Sciences Institute of Acupuncture and MoxibustionBeijing 100700China Wangjing Hospital China Academy of Chinese Medical SciencesBeijing 100102China Guang'anmen Hospital China Academy of Chinese Medical SciencesBeijing 100053China Hubei University of Chinese Medicine Wuhan 430061China North China University of Science and Technology Tangshan 063210HebeiChina

Objective:To explore the effect and its possible mechanism of the intervention of transcutaneous auricular vagus nerve stimulation(taVNS)for the functional dyspepsia(FD)model ***:Of the 25 male SD rats,6 rats were set as blank group,the other 19 rats were established to be the functional dyspepsia(FD)model by iodoacetamide intragastric administration,and 18 FD models were successfully *** 18 model rats were randomly divided into a model group,a shamtaVNS group,and taVNS group,with 6 rats in each *** was no intervention applied to the rats in the blank and model ***,the rats in sham-taVNS group received stimulation to the rim of auricular concha of both sides,and those in taVNS group received stimulation to the cavity of auricular concha of both sides,for 30 min each time,once a day,7 days in *** the intervention,the gastric sensitivity of the rats in each group under different pressure conditions in the stomach,the expressions of serum brain-gut peptide motilin(MTL),cholecystokinin(CCK),glucagon-likepeptidel(GLP-1),and inflammatory factors IL-4,IL-10,and IL-1βwere ***:(1)Gastric sensitivity:compared with the blank group,the gastric sensitivity of the model group was higher(P<0.05).Compared with the model group,the gastric sensitivity of the taVNS group was lower(P<0.05).Compared with the sham-taVNS group,the gastric sensitivity of the taVNS group was lower(P<0.05).(2)Expression of brain-gut peptide:compared with the blank group,MTL was lower,CCK and GLP-1 were higher in the model group(all P<0.05).Compared with the model group,MTL was higher,CCK and GLP-1 were lower in the taVNS group(all P<0.05).Compared with the shamtaVNS group,CCK and GLP-1 were lower in the taVNS group(both P<0.05).(3)Expression of inflammatory factors:compared with the blank group,IL-4 and IL-10 were lower and was higher in the model group(all P<0.05).Compared with the model group,IL-10 was higher and IL-1βwas lower in the shamta

关键词： transcutaneous auricular vagus nerve stimulation(taVNS) Functional dyspepsia(FD) Vagus nerve Inflammatory factor Brain-gut peptide

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Two-and Three-Layered Dissolving Microneedles for transcutaneous Delivery of Model Vaccine Antigen in Rats

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Journal of Biomaterials and Nanobiotechnology 2012年第3期3卷 325-334页

作者： Asuka Ikejiri Yukako Ito Seishiro Naito Kanji Takada Department of Pharmacokinetics Kyoto Pharmaceutical University Kyoto Japan Department of Safety Research on Blood and Biological Products National Institute of Infectious Diseases Tokyo Japan.

Purpose: Comparison of transcutaneous immunization of ovalbumin (OA) between two-and three-layered dissolving microneedles (MN) in rats. Methods: We prepared 500 μm long two-layered and three-layered dissolving microneedle (2-MN and 3-MN, respectively) arrays from chondroitin sulfate as the base, and OA as the model antigen. The 2-MN containing OA at the acral portion and 3-MN with OA at the second portion were administered to rat skin transcutaneously. As a positive control, OA solution was injected subcutaneously (sc). The OA delivery and diffusion in the rat skin were studied using confocal microscopy with fluorescein-conjugated OA (FL-OA). Results: The formulated positions of OA were 0-155 ± 5 μm for 2-MN and 175 ± 4 – 225 ± 5 μm for 3-MN. The administered doses of OA were 2.2 ± 0.1 μg, 12.0 ± 0.2 μg and 22.0 ± 0.2 μg for 2-MN, 1.8 ± 0.2 μg, 12.6 ± 0.7 μg, and 20.4 ± 0.3 μg for 3-MN, 10 μg, 100 μg and 1000 μg for sc injection. At 4 weeks after the first administration, 3-MN showed about 2.5-7.0 fold and 5.4 fold higher total Ig (G + A + M) antibody than 2-MN and sc injection of the OA solution. Conclusions: The 3-MN, which delivered OA to the epidermis, is a useful drug delivery system for transcutaneous antigen delivery.

关键词： Dissolving Microneedles (Mns) Two-Layered Mns Three-Layered Mns transcutaneous Vaccine Ovalbumin Fl-Ovalbumin (Fl-Oa)

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The Safety and Efficacy of transcutaneous Nerve Stimulation (TENS) in Reducing Vaginal Delivery Labor Pain: Randomized Controlled Clinical Trial

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Open Journal of Obstetrics and Gynecology 2020年第5期10卷 657-670页

作者： Hanan A. A. Farra Hatem S. Shalaby Ahmed A. Fahmy Maii Nawara Department of Obstetrics and Gynecology Ain Shams University Cairo Egypt

Background: Labor analgesia remains the center of interest for both obstetricians and women. The safety of the traditional pharmacologic analgesics remains questionable due to their potential fetal and maternal complications. Therefore, several non-pharmacological modalities were evaluated for their safety and efficacy to relieve labor pain. Among these methods, transcutaneous nerve stimulation (TENS) gained much concern due to ease of use, low cost and high capacity for women self-titration. The study aims to investigate the efficacy of TENS in reducing labor pain associated with vaginal deliveries, and to determine the factors controlling the response to TENS. Methods: The study was a randomized, controlled clinical trial. A total of 390 women candidates for vaginal delivery were randomly allocated to 3 groups of intervention: paracetamol infusion, TENS, and intramuscular pethidine (130 women per group). The primary endpoint was pain intensity assessed on 10-point VAS scale and women satisfaction. Secondary endpoints included maternal or fetal complications. Results: VAS scores recorded during vaginal deliveries demonstrated a statistically significant reduction in TENS group compared to paracetamol at 15, 30 minutes, 1 and 2 hours, while pethidine arm demonstrated lower scores than TENS group (p < 0.001). The intermediate analgesic efficacy of TENS was preserved when evaluating episiotomy related pain scores. Analysis of differences between good and poor responders to TENS indicated that weight, BMI, education level and the stimulation characteristics were statistically different between the two subgroups (p < 0.001). Adverse maternal and fetal outcomes in TENS arm were comparable to paracetamol and significantly less than pethidine. Conclusion: TENS is a reliable labor pain analgesic with comparable efficacy and superior safety relative to pethidine. Clinicians should personalize TENS therapy according to women’s BMI and education level for optimized pain contro

关键词： transcutaneous Nerve Stimulation Vaginal Delivery Labor Pain

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Preliminary Validation of transcutaneous CO<sub>2</sub>Monitoring in Patients Undergoing Cardiac Ablation Using Jet Ventilation

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Open Journal of Anesthesiology 2017年第9期7卷 315-327页

作者： Zvi C. Jacob Roger Fan Ruth A. Reinsel Nehul Patel Arvind Chandrakantan Department of Anesthesiology Stony Brook Medicine Stony Brook NY USA Division of Cardiology Department of Medicine Stony Brook Medicine Stony Brook NY USA Current Address: Department of Anesthesiology Texas Children’s Hospital Houston TX USA

Objectives: There is no data in the current medical literature on efficacy or accuracy of transcutaneous (tcPCO2) monitoring during jet ventilation for cardiac ablation. The use of tcPCO2 during cardiac ablation procedures offers the opportunity to compare end-tidal and transcutaneous methods of CO2 measurement before and after the use of the jet ventilation. Comparison of these measurements with arterial blood gas CO2 levels allows evaluation of the accuracy of the tcPCO2 technique for use during jet ventilation. Design: Observational study;patients served as their own controls. Setting: Cardiac electrophysiology laboratory. Participants: 15 adult patients (9 M), ASA III-IV, aged 26 to 82 years (median 66 years) undergoing radiofrequency ablation for atrial fibrillation. Interventions: Jet ventilation (JV) versus conventional ventilation. Measurements and Main Results: Paired measurements of end-tidal CO2 (EtCO2) and transcutaneous CO2 (tcPCO2) were recorded during periods of conventional ventilation. Paired measurements of arterial blood CO2 (PaCO2) levels and tcPCO2 were recorded during JV. ABG samples were drawn at the anesthesiologist’s discretion to assess the patient’s respiratory status. The level of agreement between the three methods was compared using the Bland Altman plot. We found that tcPCO2 values consistently provided a close approximation to PaCO2 levels. The mean difference between tcPCO2 and EtCO2 values in baseline and post-JV was on the order of 3 - 5 mmHg, with standard deviation of 4 - 6 mmHg. This is well within the range of variability that is accepted in clinical practice. Conclusions: These preliminary results suggest that tcPCO2 provides an acceptable estimate of CO2 concentration in arterial blood during JV, as well as prior to and following JV.

关键词： High Frequency Jet Ventilation Cardiac Ablation transcutaneous CO2 Monitoring End-Tidal CO2 Monitoring General Anesthesia

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The transcutaneous Vagus Nerve Stimulation Output of the NuCalm Device of Solace Lifesciences Is Found to Be a Multifractal and Therefore It Is Indicated in the Treatment of Heart Rate Variability in the Dysfunction of Autonomic Nervous System in Anxiety, Depression and Stress

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Journal of Behavioral and Brain Science 2017年第11期7卷 532-543页

作者： Sergio Conte Fang Wang Nicoletta Sala Francesco Losito Casciaro Franco Orsucci Giuseppe Serafini Ferda Kaleagasioglu Leonardo Mendolicchio Rich Norman Elio Conte School of Advanced International Studies on Applied Theoretical and Non Linear Methodologies of Physics Bari Italy College of Science/Agricultural Mathematical Modeling and Data Processing Center Hunan Agricultural University Changsha China University of Lugano ISSI/Cerfim Lugano Swizerland Department of Biomedical Sciences and Human Oncology University of Bari Bari Italy Division of Psychology University College London England Tor Vergata University Rome Italy Faculty of Medicine Near East University North Nicosia Turkish Republic of Northern Cyprus Clinic Villa Miralago ASL Varese Italy

We have investigated the Nu Calm transcutaneous Vagus Nerve Stimulation device of the NuCalm Solace Lifesciences founding that it gives a multifractal output. A diminishing fractal/multifractal HRV is consistently reported in literature as related to a serious Autonomic Nervous System (ANS) dysfunction that of course we observe in several psychological and psychiatric disorders. Therefore, we suggest the investigators to apply such a device in subjects affected from anxiety, depression and stress using the method of inducing tVNS stimulation.

关键词： Depression Anxiety Stress transcutaneous Vagus Nerve Stimulation Neuromodulation Heart Rate Variablity Multifractals

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Lower Blepharoplasty Review, Transcon-junctival vs. transcutaneous Approach

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Modern Plastic Surgery 2015年第1期5卷 1-8页

作者： Alberto Rancati Patricio Jacovella Andrea Edoardo Zampieri Julio Dorr Mariana Daniele Santiago Liedtke Agustin Rancati Plastic Surgery Division University of Buenos Aires (UBA) Buenos Aires Argentina

Currently in lower blepharoplasty, the transconjunctival approach indication has been limited to young patients without skin excess and prominence of bags;in our practice this access has become the preferred technique in most of our cases because it is simpler, faster, prevents bad scarring, produces less orbicularis muscle trauma, and decreases postoperative edema and possible retractions (ectropion) in patients with decreased lower palpebral tone. Objective: To identify important concepts when deciding this approach. Material and Methods: Retrospective review of 177 patients who underwent lower blepharoplasty by a single surgical group. Regarding techniques, the transconjunctival approach was selected in 42% of patients while the transcutaneous technique was preferred in 58%. Results: A lower rate of complications was observed by the transconjunctival approach, with greater patient satisfaction. Conclusions: In our experience, due to its simplicity and less traumatic effect on the patient, the transconjunctival approach is an ideal technique, except in cases where there is lower eyelid weakness and surgical resolution is needed.

关键词： Transconjunctival Approach transcutaneous Approach Blepharoplasty

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Continuous transcutaneous monitoring of peripheral oxygen and carbon dioxide during infant cardiac surgery

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Advances in Bioscience and Biotechnology 2012年第7期3卷 824-827页

作者： Heping Zhou Hongyan Xiong Chunhu Gu Tao Chen Hailong Zhu Guocheng Sun Department of Cardiothoracic Surgery Central Hospital of Xi’an Xi’an China Department of Cardiovascular Surgery Xijing Hospital the Fourth Military Medical University Xi’an China

Close monitoring of the balance between oxygen demand and supply is of great importance during cardiac cardiopulmonary bypass (CPB) surgery. This study was to compare conventional intermittent venous blood gas monitoring with continuous transcutaneous oxygen and carbon dioxide monitoring in infant patients undergoing cardiac surgery with CPB. According to paired data from 29 infant patients undergoing cardiac surgery we found that a positive correlation existed between the two techniques, with a correlation coefficient 0.9021 and 0.8021 for PO2 and PCO2 respectively. It’s concluded that transcutaneous monitoring and intermittent venous blood sampling had good correlation and transcutaneous monitoring may be used conveniently and safely clinically during CPB.

关键词： Cardiopulmonary Bypass Blood Gas transcutaneous Monitoring

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