Effect and mechanism study on transcutaneous auricular vagus nerve stimulation for functional dyspepsia model rats

作     者：Li-wei HOU Pei-jing RNG Wei WEI Ji-liang FANG Dan WANG Wei-hang ZHAI Yu WANG Jun-ying WANG 侯理伟;荣培晶;魏玮;方继良;王丹;翟伟航;王瑜;王俊英

作者机构：China Academy of Chinese Medical SciencesInstitute of Acupuncture and MoxibustionBeijing 100700China Wangjing HospitalChina Academy of Chinese Medical SciencesBeijing 100102China Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Hubei University of Chinese MedicineWuhan 430061China North China University of Science and TechnologyTangshan 063210HebeiChina 

出 版 物：《World Journal of Acupuncture-Moxibustion》 (世界针灸杂志（英文版）)

年 卷 期：2020年第30卷第1期

页      面：49-56页

核心收录：

学科分类：1005[医学-中医学] 1002[医学-临床医学] 100512[医学-针灸推拿学] 10[医学] 

基　　金：Supported by International Cooperation and Exchange of the National Natural Science Foundation of China:NO.81820108033 81473780 The Fundamental Research Funds for the Central public welfare research institutes:NO.ZZ201915009 

主　　题：Transcutaneous auricular vagus nerve stimulation(taVNS) Functional dyspepsia(FD) Vagus nerve Inflammatory factor Brain-gut peptide 

摘      要：Objective:To explore the effect and its possible mechanism of the intervention of transcutaneous auricular vagus nerve stimulation(taVNS)for the functional dyspepsia(FD)model ***:Of the 25 male SD rats,6 rats were set as blank group,the other 19 rats were established to be the functional dyspepsia(FD)model by iodoacetamide intragastric administration,and 18 FD models were successfully *** 18 model rats were randomly divided into a model group,a shamtaVNS group,and taVNS group,with 6 rats in each *** was no intervention applied to the rats in the blank and model ***,the rats in sham-taVNS group received stimulation to the rim of auricular concha of both sides,and those in taVNS group received stimulation to the cavity of auricular concha of both sides,for 30 min each time,once a day,7 days in *** the intervention,the gastric sensitivity of the rats in each group under different pressure conditions in the stomach,the expressions of serum brain-gut peptide motilin(MTL),cholecystokinin(CCK),glucagon-likepeptidel(GLP-1),and inflammatory factors IL-4,IL-10,and IL-1βwere ***:(1)Gastric sensitivity:compared with the blank group,the gastric sensitivity of the model group was higher(P0.05).Compared with the model group,the gastric sensitivity of the taVNS group was lower(P0.05).Compared with the sham-taVNS group,the gastric sensitivity of the taVNS group was lower(P0.05).(2)Expression of brain-gut peptide:compared with the blank group,MTL was lower,CCK and GLP-1 were higher in the model group(all P0.05).Compared with the model group,MTL was higher,CCK and GLP-1 were lower in the taVNS group(all P0.05).Compared with the shamtaVNS group,CCK and GLP-1 were lower in the taVNS group(both P0.05).(3)Expression of inflammatory factors:compared with the blank group,IL-4 and IL-10 were lower and was higher in the model group(all P0.05).Compared with the model group,IL-10 was higher and IL-1βwas lower in the shamta