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The value of toxicological analysis in acute poisoning patients with uncertain exposure histories:a retrospective and descriptive study from an institute of poisoning

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World Journal of Emergency Medicine 2024年第2期15卷 98-104页

作者： Qifang Shi Gen Ba Zhenyu Xia Zhengsheng Mao Hao Sun Jinsong Zhang Institute of Poisoning Nanjing Medical UniversityNanjing 211100China Department of Emergency Medicine the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Forensic Medicine Nanjing Medical UniversityNanjing 211166China The Key Laboratory of Modern Toxicology of Ministry of Education Nanjing Medical UniversityNanjing 211166China

BACKGROUND:In clinical practice,some patients might not be able or unwilling to provide a thorough history of medication and poison exposure.The aim of this study was to use toxicological analysis to examine the clinical characteristics of patients with acute poisoning whose exposure history was uncertain from a toxicological analysis perspective.METHODS:This was a retrospective and descriptive study from an institute of poisoning.Patient registration information and test reports spanning the period from April 1,2020 to March 31,2022,were obtained.Patients with uncertain exposure histories and who underwent toxicological analysis were included.Clinical manifestations and categories of toxics were analyzed.RESULTS:Among the 195 patients with positive toxicological analysis results,the main causes of uncertain exposure history was disturbance of consciousness(62.6%),unawareness(23.6%)and unwillingness or lack of cooperation(13.8%).The predominant clinical manifestations were disturbed consciousness(62.6%),followed by vomiting and nausea(14.4%)and liver function abnormalities(8.7%).A comparison of clinical manifestations between patients with positive and negative(n=99)toxicological analyses results revealed significantly different proportions of disturbances in consciousness(63%vs.21%),dizziness(1.5%vs.5.1%),multi-organ failure(1.5%vs.7.1%),and local pain(0 vs 4%).The main categories of substances involved were psychiatric medications(23.1%),sedatives(20.5%),insecticides(13.8%),and herbicides(12.8%).CONCLUSION:The clinical manifestations of acute poisoning in patients with an uncertain exposure history are diverse and nonspecific,and toxicological analysis plays a pivotal role in the diagnosis and differential diagnosis of such patients.

关键词： Acute poisoning Toxic exposure toxicological analysis Clinical manifestation

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Molecularly imprinted polymers for highly sensitive detection of morphine using surface plasmon resonance spectroscopy

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Chinese Chemical Letters 2011年第4期22卷 477-480页

作者： Hong Xia Hao Hong Zhou Jing Chang Jun Zhu Tian Xin Wei Key Laboratory of Evidence Science(CUPL) Ministry of EducationBeijing 100088China Forensic Sciences Institute Ministry of Public SecurityBeijing 100038China Department of Science Beijing Institute of TechnologyBeijing 100081China

Molecular imprinting technology is applied in surface plasmon resonance spectroscopy for highly sensitive and selective detection of morphine（MO）.As SPR-based sensor of MO,the preparation of molecular imprinted polymer is as follows： methacryhc acids（MAA）,ethylene glycol dimethacrylate（EGDMA）,azodiisobutyronitrile（AIBN） were used as functional monomer,cross-linker and initiator,respectively.The experiment results showed that morphine imprinted polymer had the performance of high sensitivity and specificity,i.***.the relative signal of SPR response was proportional to the concentration of morphine in acetonitrile in the range of 10^（-9）mol/L to 10^（-6）mol/L（1 ppb-1 ppm） with LOD of 10^（-10）mol/L,and MO was distinguished from its analogs,such as codeine.

关键词： Molecular imprinting technique（MIT） Surface plasmon resonance（SPR） Morphine toxicological analysis

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A　New　Method　for　Brucine　analysis　Based　on　Its　Chemiluminescence　Reaction　with　Potassium　Permanganat

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Chemical Research in Chinese Universities 1997年第3期13卷 229+33623+232-234页

作者： YANG Min-li , FENG Man-Iang , LU Jiu-ru (Department of Chemistry, Shaanxi Normal University, Xian, 710062) SHAANXI NORMAL UNIV DEPT CHEMXIAN 710062PEOPLES R CHINA

ＡＮｅｗＭｅｔｈｏｄｆｏｒＢｒｕｃｉｎｅＡｎａｌｙｓｉｓＢａｓｅｄｏｎＩｔｓＣｈｅｍｉｌｕｍｉｎｅｓｃｅｎｃｅＲｅａｃｔｉｏｎｗｉｔｈＰｏｔａｓｓｉｕｍＰｅｒｍａｎｇａｎａｔｅＹＡＮＧＭｉｎ－ｌｉ，ＦＥＮＧＭａｎ－Ｉ... 详细信息

ＡＮｅｗＭｅｔｈｏｄｆｏｒＢｒｕｃｉｎｅＡｎａｌｙｓｉｓＢａｓｅｄｏｎＩｔｓＣｈｅｍｉｌｕｍｉｎｅｓｃｅｎｃｅＲｅａｃｔｉｏｎｗｉｔｈＰｏｔａｓｓｉｕｍＰｅｒｍａｎｇａｎａｔｅＹＡＮＧＭｉｎ－ｌｉ，ＦＥＮＧＭａｎ－Ｉａｎｇ，ＬＵＪｉｕ－ｒｕ（Ｄｅｐａ...

关键词： Chemiluminescence Brucine toxicological analysis

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Advances in Toxins and Narcotics Determination Techniques in China During 2013

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Journal of Forensic Science and Medicine 2015年第1期1卷 54-60页

作者： Ling Zeng Zhicheng Liu Xu Han Hongxia Hao Key Laboratory of Evidence Science China University of Political Science and LawMinistry of EducationBeijing Collaborative Innovation Center of Judicial Civilization China

Recently,toxin and narcotics detection techniques have been developed in China.A number of new technologies have been applied.The pretreatment technologies such as solid‑phase extraction(SPE)techniques,solid‑phase microextraction(SPME)techniques,hollow‑fiber liquid‑phase microextraction(HF‑LPME)techniques,etc.,have matured,and thus have greatly improved both the accuracy and efficiency of the analysis of toxins and narcotics as well as the technical system of analysis.Based on analyses conducted using the traditional methods of gas chromatography(GC)as well as other conventional methods,various new methods of analysis have been gradually discovered and developed.For instance,ultra‑performance liquid chromatography(UPLC)‑mass spectrometry(MS)and other combination technologies have enriched the variety of detection methods that are available to researchers.These highly precise methods are developed on the basis of and as extensions of traditional applications and still draw the attention of researchers from a variety of disciplines.

关键词： Narcotics toxicological analysis toxins

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analysis OF STRYCHNINE ALKALOIDS IN BIOLOGICAL SAMPLES BY THIN-LAYER CHROMATOGRAPHIC DENSITOMETRY AND DISTRIBUTION STUDY OF STRYCHNINE IN INTOXICATED RATS

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Journal of Pharmaceutical analysis 1998年第2期12卷 146-149,180页

作者：傅强贺浪冲常春苗治平 College of Pharmacy Xi'an Medical University Xi'an 710061 China

A sensitive and rapid analytical procedure was established to detrmine strychnie alkaloids in diverse biological specimens. Samples were treated with hydrochloric acid to precipitate protein and scanned in thin-layer chromatograpic scanner in zig-zag dual-wavelength reflection mode.Detection sensitivity for strychniue was about 0. 05 μg. Quantification recoveries were between89. 2% and 99. 5% with RSD between 2. 92% and 13. 21 %. The method was applied to investigate thedistribution or strychnine in intoxicated rats. The results showed that there were remarkable difference in organs or tissues with the aigaest concentration 4. 56±1. 41μg/g in liver. Diversification experiment proves the method also could be used to analyze other alkaloids in biological samples if theconditions slightly modified.

关键词： strychnine alkaloids biological samples toxicological analysis thin-layer chromatographic densitometry

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经福尔马林固定的脏器组织中有机磷农药的GC-MS检验

经福尔马林固定的脏器组织中有机磷农药的GC-MS检验

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2005年全国有机质谱学术交流会

作者：王玫孟广范袁增平北京市公安局法医检验鉴定中心

有机磷农药检验是刑事毒物检验中一项重要内容,常规的检材如血液、胃内容中有机磷农药检验已有很成熟的检验方法。但有时案件检材特殊,需要研究一些特殊的检验方法。本文结合一起较特殊的案例(无常规的检材),研究了经福尔马林固定2年之... 详细信息

有机磷农药检验是刑事毒物检验中一项重要内容,常规的检材如血液、胃内容中有机磷农药检验已有很成熟的检验方法。但有时案件检材特殊,需要研究一些特殊的检验方法。本文结合一起较特殊的案例(无常规的检材),研究了经福尔马林固定2年之久的肝脏组织中有机磷农药的提取、净化及GC-MS检验方法,为案件的审理提供了准确、可靠的科学依据。

关键词： toxicological analysis Organophosphorus pestide GC - MS

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