Molecularly imprinted polymers for highly sensitive detection of morphine using surface plasmon resonance spectroscopy

作     者：Hong Xia Hao Hong Zhou Jing Chang Jun Zhu Tian Xin Wei 

作者机构：Key Laboratory of Evidence Science(CUPL)Ministry of EducationBeijing 100088China Forensic Sciences InstituteMinistry of Public SecurityBeijing 100038China Department of ScienceBeijing Institute of TechnologyBeijing 100081China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2011年第22卷第4期

页      面：477-480页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 080202[工学-机械电子工程] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 0802[工学-机械工程] 0703[理学-化学] 

基　　金：the Innovation Project of the Ministry of Public Security of the People's Republic of China(No. 2008YYCXGKXXS130) Academician Foundation of the Ministry of Public Security of the People's Republic of China(No.2011-23210044) the National Natural Science Foundation of China(No.81001348) for their financial supports 

主　　题：Molecular imprinting technique(MIT) Surface plasmon resonance(SPR) Morphine Toxicological analysis 

摘      要：Molecular imprinting technology is applied in surface plasmon resonance spectroscopy for highly sensitive and selective detection of morphine（MO）.As SPR-based sensor of MO,the preparation of molecular imprinted polymer is as follows： methacryhc acids（MAA）,ethylene glycol dimethacrylate（EGDMA）,azodiisobutyronitrile（AIBN） were used as functional monomer,cross-linker and initiator,*** experiment results showed that morphine imprinted polymer had the performance of high sensitivity and specificity,*** relative signal of SPR response was proportional to the concentration of morphine in acetonitrile in the range of 10^（-9）mol/L to 10^（-6）mol/L（1 ppb-1 ppm） with LOD of 10^（-10）mol/L,and MO was distinguished from its analogs,such as codeine.