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Chemical Research in Chinese Universities 2016年第4期32卷 647-654页

作者： REN Hejun ZHANG Ruonan WANG Qiaochu PAN Hongyu WANG Yan Key Laboratory of Groundwater Resources and Environment Ministry of Education College of Environment and Resources Jilin University Changchun 130021 P. R. China College of Plant Sciences Jilin University Changchun 130062 P. R. China

The potential of the agricultural waste garlic root to remove malachite green（MG） from aqueous solutions was evaluated. The adsorption of this dye onto garlic root was confirmed by means of Fourier transform infrared analysis（FTIR） and scanning electron microscopy（SEM）. The equilibrium data fitted well into the Langmuir model（R2〉0.99）, and the adsorption kinetics followed the pseudo-second-order equation（R2〉0.99）. The maximum ad- sorption capacities of MG onto the adsorbent were 172.41 and 232.56 mg/g with the addition of 1 and 2 g/L garlic root, respectively. The optimal conditions for MG removal were established on the basis of orthogonal experiments（OAl6 matrix）. The concentrations of both MG and garlic root significantly affected the removal efficiency. The acute toxicity test indicated that the treated MG solutions were less toxic than the parent solutions. These results suggest that garlic root is a potential low-cost adsorbent for removing dye from industrial wastewater.

关键词： Garlic root Malachite green Adsorption toxicity test Wastewater

Morphological Features of Agaricus bisporus and Indoor toxicity test of Chemicals

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Plant Diseases and Pests 2015年第1期6卷 22-24,40页

作者： Xie Chunqin Chen Xiaoyin Yang Hetong Xie Zhenglin Chen Yi Shao Mei Jiangsu Polytechnic College of Agriculture and Forestry

Through separating and purifying diseased mushrooms infected by Mycogone perniciosa in Gaochun Area, Nanjing City, morphological features of the bacteria were identified, and toxicity of the bacterial strains was tested. The results showed that five bactericides in the experiment had obvious inhibitory effect on the growth of M. perniciosa, especially 50% Prochloraz manganese chloride complex WP 5 g/L had the best efficiency.

关键词： Agaricus bisporus Mycogone perniciosa Chemical toxicity test

A novel respirometer for biological toxicity tests

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Journal of Environmental Sciences 1997年第3期9卷 92-98页

作者： Zhang Minquan Chen Huanqin Wong Kwok-Yin Chemical Engineering Research Institute South China University of TechnologyGuangzhou 510641 China Department of Applied Biobgy and Chemical Technology The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong

A respirometer has been developed for microbial toxicity tests. The respirometer is based on luminescence quenching by molecular oxygen. The oxygen sensing film consists of luminescent ruthenium complex adsorbed on amorphous fumed silica and immobilized inside silicone rubber. The luminescence intensity depends on the oxygen concentration of sample in contact with sensing film. The inhibition effect of heavy metals on the respiration rate of microorganisms can be evaluated by monitoring the luminescence intensity of the sensing film. The toxicity of Cu 2+ , Zn 2+ , Ni 2+ , Cr 3+ , Pb 2+ and Hg 2+ on activated sludge was tested using the respirometer. The results indicated that the proposed method was sensitive to the heavy metals tested in this experiment. It was feasible to use the respirometer for microbial toxicity tests.

关键词： luminescence quenching respirometer toxicity test heavy metal.

toxicity testing of four silver nanoparticle-coated dental castings in 3-D LO2 cell cultures

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2018年第2期19卷 159-167页

作者： Yi-ying ZHAO Qiang CHU Xu-er SHI Xiao-dong ZHENG Xiao-ting SHEN Yan-zhen ZHANG Department of Food Science and Nutrition Zhejiang Key Laboratory for Agro-Food ProcessingFuli Institute of Food Science Huajiachi Dental Center Stomatology Hospital Affiliated to Zhejiang University of Medicine Department of General Dentistry the Second Affiliated Hospital School of Medicine Zhejiang University

To address the controversial issue of the toxicity of dental alloys and silver nanoparticles in medical ap- plications, an in vivo-like LO2 3-D model was constructed within polyvinylidene fluoride hollow fiber materials to mimic the microenvironment of liver tissue. The use of microscopy methods and the measurement of liver-specific functions optimized the model for best cell performances and also proved the superiority of the 3-D LO2 model when compared with the traditional monolayer model. toxicity tests were conducted using the newly constructed model, finding that four dental castings coated with silver nanoparticles were toxic to human hepatocytes after cell viability assays. In general, the toxicity of both the castings and the coated silver nanoparticles aggravated as time increased, yet the nanoparticles attenuated the general toxicity by preventing metal ion release, especially at high concentrations.

关键词： LO2 cell 3-D model Silver nanoparticles Dental alloys toxicity test

Degradation of differently processed Mg-based implants leads to distinct foreign body reactions(FBRs)through dissimilar signaling pathways

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Journal of Magnesium and Alloys 2023年第6期11卷 2106-2124页

作者： Xiaosong Liu Guoqiang Chen Xiongxiong Zhong Tianfang Wang Xiaohong He Weipeng Yuan Pingping Zhang Ying Liu Dongming Cao Shu Chen Ken-ichi Manabe Zhengyi Jiang Tsuyoshi Furushima Damon Kent Yang Chen Guoying Ni Mingyong Gao Hejie Li Cancer Research Institute First People’s Hospital of FoshanFoshanGuangdong 528000China Department of Rheumatology First People’s Hospital of FoshanFoshanGuangdong 528000China The Second Clinical Medical College of Jinan University Shenzhen People’s HospitalShenzhenGuangdong 510632China Genecology Research Centre University of the Sunshine CoastMaroochydore BCQLD 4558Australia Department of Medical Imaging First People’s Hospital of FoshanFoshanGuangdong 528000China Department of Surgery First People’s Hospital of FoshanFoshanGuangdong 528000China Department of Mechanical Engineering Graduate School of Science and EngineeringTokyo Metropolitan University1-1 Minami-osawaHachiojiTokyo 192-0397Japan School of Mechanical MaterialsMechatronic and Biomedical EngineeringFaculty of Engineering and Information SciencesUniversity of WollongongNorthfields AveWollongong NSW 2522Australia Institute of Industrial Science Department of Mechanical and Biofunctional Systemsthe University of Tokyo4-6-1KomabaMeguroTokyo 153-8505Japan School of Science Technology and EngineeringUniversity of the Sunshine CoastMaroochydore BCQLD 4558Australia

Mg alloys have mechanical properties compatible with human ***,their rapid degradation and associated foreign body reactions in vivo significantly limit their application for human *** this study,three differently processed Mg alloys,pure Mg(PM),cold extruded Mg alloy AZ31(CE AZ31),and fully annealed AZ31 Mg alloy(FA AZ31)were comparatively investigated for their potential as implants using a rat *** three implanted Mg alloys do not show any impact on hepato-and renal function,nor any signs of observable changes to vital *** analysis of tissues directly contacting the implants 2.5 months post implantation revealed that FA AZ31 activates very few inflammation and immune associated signaling pathways;while the CE AZ31 and PM produce more significant inflammatory responses as confirmed by cytokine array ***,FA AZ31 activated pathways for cell organization and development that may improve the recovery of injured ***,EBSD analysis reveals that the FA AZ31 alloy has a higher ratio of first-order pyramidal orientated(10–11){10–1–2}grain texture with a value of 0.25,while PM and CE AZ31 alloys have lower ratios of first-order pyramidal orientated texture with the values of 0.16 and 0.17,*** is associated with recovery and recrystallisation during annealing which promotes grain texture which exhibits enhanced degradation behaviours and induces a more limited immune response in *** conclusion,the FA AZ31 demonstrated better biocompatibility and corrosion resistance and is a promising candidate for metal-based degradable implants which warrants further investigation.

关键词： toxicity test Proteomics analysis Signaling pathway Biocompatibility and corrosion resistance First-order pyramidal slip system Recovery and recrystallization Foreign body reactions(FBRs)

Extraction optimization of insecticidal compounds from Lysurus mokusin by response surface methodology

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Journal of Forestry Research 2020年第5期31卷 1985-1993页

作者： Liannan Lin Jing Yang Guocai Zhang Xiaobo Zhang Chuanshan Zou Tingyu Wang Jianyong Zeng School of Forestry Northeast Forestry UniversityHarbin 150040People’s Republic of China

We optimized the extraction process of Lysurus mokusin(L.)*** compound(LMIC)using response surface methodology with ultrasonic extraction(UE).The surface morphologies of maceration extract(ME)and UE residues were compared by scanning electron microscopy,and then the activity of LMIC on Lymantria dispar(Asian gypsy moths)larvae was *** showed that the optimal condition of UE was followed by 80 min of extraction time,60%of ethanol concentration and 80 mL g^-1 of liquid–solid *** surface morphologies of UE residue were looser and rougher than ME *** corrected mortalities of LMIC on *** larvae was 59.77%.This result indicated that *** was a good candidate as pesticide for pest management.

关键词： Lysurus mokusin Gypsy moth Response surface Extraction process toxicity test

toxicity of novel anti-hepatitis drug bicyclol: A preclinical study

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World Journal of Gastroenterology 2005年第5期11卷 665-671页

作者： Geng-TaoLiu YanLi Huai-LingWei HongLu HuiZhang Yu-GuiGao Ling-ZhiWang DepartmentofPharmacology InstituteofMateriaMedicaChineseAcademyofMedicalSciencesandPekingUnionMedicalCollegeBeijing100050China

AIM: To study the toxicity of bicyclol to animals. METHODS: Acute toxicity test was performed in Kunming strain mice that were orally given bicyclol at the doses of 3 and 5 g/kg body weight, respectively. Wistar rats were orally administered bicyclol at a dose of 5 g/kg body weight. Death and clinical symptoms of animals were recorded within 7 d. Sub-acute toxicity test was carried out in rats that were treated with various doses of bicyclol (150, 300, 600 mg/kg) once daily for 14 d. Animal behaviors, blood biochemical markers, blood and urine pictures were examined. Chronic toxicity test was conducted in 80 Wistar rats of both sexes. The animals were orally administered with various doses of bicyclol [150, 300, 600 mg/kg, 100-400 folds corresponding to the proposed therapeutic dose (1.5 mg/(kg·d)) of bicyclol for patients] once daily for 6 mo except for Sunday. The control group was given the same volume of 0.2% sodium carboxyl methylcellulose (Na-CMC). Twenty-one beagle dogs received bicyclol (25, 75, 225 mg/kg, 16.6, 50, 150 folds corresponding to the proposed therapeutic dose of bicyclol for patients) once a day for 6 mo except for Sunday. The body weight, food intake, urine and feces, blood picture, blood biochemical markers, and pathological examination of main organs were determined. Mutagenicity and teratogenicity were determined. Mutagenicity assay included Ames's test, chromosome aberration test in CHL cells and micronucleus test in mice. For the teratogenicity assay, pregnant Wistar rats weighing 200-250 g were treated with 0.2,1.0 g/kg bicyclol once daily from the 7th d of gestation for 10 d. RESULTS: The oral LD50 of bicyclol was over 5 g/kg in mice and rats. No noticeable alterations in subacute and chronic toxicity of rats and dogs were demonstrated. No mutagenicity and teratogenicity of bicyclol were found. CONCLUSION: Bicyclol has no detectable chronic toxicity as well as mutagenicity and teratogenicity in animals.

关键词： Bicyclol Antiviral agents toxicity test

Toxic Effect of a Pesticide, Diflubenzuron on Freshwater Microinvertebrate (Tetrahymena pyriformis)

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应用与环境生物学报 2006年第4期12卷 514-517页

作者： ROUABHI Rachid DJEBAR-BERREBBAH H DJEBAR MR Department of Biology University Center Larbi Tebessi Tebessa 12000 Algeria Laboratory of Cell Toxicology Department of Biology Faculty of Sciences Annaba University 23000 Annaba Algeria

The impact of diflubenzuron (DFB) on Tetrahymena pyriformis, a ciliated protiste was studied. The treatment with DFB at concentrations of 10 and 20 μg/mL could appreciably reduce the growth of the protiste. The surveillance of protozoa′s respiratory metabolism with polarography technique showed a sensitive inhibition of its oxygen consumption, and at 20 μg/mL concentration the oxygen consumption was increased. For any malformation of morphology and perturbation in swimming trajectory, the neutral red coloration was done. This technique (neutral red) showed that there was a toxic effect of DFB on T. pyriformis, especially at the highest concentration; this toxicity was translated by rotatory swimming in same place and the increasing of coloration quantity in digestive vacuoles. Fig 5, Ref

关键词： Tetrahymena pyriformis ciliated protiste diflubenzuron polarographic technique pesticide toxicity test respiratory metabolism

Construction and Application of in vitro Alveolar Models Based on 3D Printing Technology

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Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers) 2022年第2期1卷 58-65页

作者： Tiankun Liu Chang Zhou Yongchun Shao Zhuo Xiong Ding Weng Yuan Pang Wei Sun Department of Mechanical Engineering Biomanufacturing CenterTsinghua UniversityBeijing100084China Biomanufacturing and Rapid Forming Technology Key Laboratory of Beijing Beijing100084China State Key Laboratory of Tribology School of Mechanical EngineeringTsinghua UniversityBeijing100084China Department of Mechanical Engineering Drexel UniversityPhiladelphiaPA 19104USA

Increasing lung diseases,mutating coronaviruses,and the development of new compounds urgently require biomimetic in vitro lung models for lung pathology,toxicology,and *** current construction strategies for lung models mainly include animal models,2D cell culture,lung-on-a-chip,and lung ***,current models face difficulties in reproducing in vivo-like alveolar size and vesicle-like structures,and are unable to contain multiple cell *** this study,a strategy for constructing alveolar models based on degradable hydrogel microspheres is *** microspheres,200-250μm in diameter,were prepared using a self-developed printing technique driven by alternating viscous and inertial *** were further constructed using a coacervation-based layer-by-layer technique and core *** types of cells were inoculated and co-cultured on hydrogel capsules based on optimized microcapsule surface treatment ***,an in vitro three-dimensional endothelial alveolar model with a multicellular composition and vesicle-like structure with a diameter of approximately 230μm was successfully *** in the constructed alveolar model maintained a high survival *** LD_(50)values of glutaraldehyde based on the constructed models were in good agreement with the reference values,validating the potential of the model for future toxicant and drug detection.

关键词： 3D printing Lung model Hydrogel beads Microcapsule toxicity test

The anti-angiogenic and antibacterial effect of Tinomiscium philippinense Miers.(Menispermaceae)leaf extract

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Journal of Coastal Life Medicine 2016年第1期 61-68页

作者： Sheryl Rena-Aguila Mario A.Tan Oliver B.Villaflores The Graduate School University of Santo TomasManilaPhilippines College of Science University of Santo TomasManilaPhilippines Research Center for the Natural and Applied Sciences University of Santo TomasManilaPhilippines College of Nursing University of Santo TomasManilaPhilippines

Objective:To determine the toxicity profile,anti-angiogenic and antibacterial activity of the crude and semi-crude leaf extracts of Tinomiscium philippinense(***).Methods:The leaves of *** were extracted with methanol and partitioned with solvents of different polarities,namely,hexane,dichloromethane and *** extracts were subjected to duck chorioallantoic membrane assay to establish its anti-angiogenic *** assay was utilized to determine the minimum inhibitory concentration and minimum bactericidal concentration of the different extracts of the ***:The dichloromethane leaf extract of *** at 1000μg/disc showed the highest anti-angiogenic activity with 37.46%*** the fractions exhibited a bacteriostatic and bactericidal effect on the three bacterial strains with Pseudomonas aeruginosa,a Gram negative lactose fermenter exhibiting a higher sensitivity to dichloromethane semi-crude extract among the treatment *** the toxicity test,no mortality and no change in behavior were observed in the Sprague-Dawley rats 14 days after the oral administration of the plant *** methanolic leaf extract of *** is non-toxic at a maximum dose of 5000 mg/***:The dichloromethane leaf extract of *** is a potential antiangiogenic endemic plant *** plant extract is also a potential antibacterial candidate as determined by microwell *** anti-angiogenic and antibacterial activity of the plant may be attributed to the essential oil,steroid,flavonoid,sterol and triterpene content of the plant.

关键词： Tinomiscium philippinense Duck chorioallantoic membrane assay Antibacterial assay toxicity test