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Potential prospects of Chinese medicine application in diabetic retinopathy

World Journal of Diabetes 2024年第10期15卷 2010-2014页

作者： Yi-Mai Zhou Yuan-Hao Cao Jing Guo Lu-Sha Cen The First Clinical Medical College Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina Department of Dermatology The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou 310006Zhejiang ProvinceChina Department of Ophthalmology The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou 310006Zhejiang ProvinceChina

Current treatment strategies for diabetic retinopathy(DR),an eye condition that can lead to blindness,have mainly focused on proliferative DR,including vitreous injection,retinal photocoagulation,and *** injections mainly depend on anti-vascular endothelial growth factor *** this editorial,we comment on the article by Sun et *** focus specifically on the mechanisms of the protective effect of genipin on the *** is a gardenia extract used in traditional Chinese medicine(TCM).In their study,the authors suggest that controlling advanced glycosylation by the intraocular injection of genipin may be a strategy for preventing *** innovative use of a Chinese medicine extract injected into the eye to achieve a curative effect has attracted our *** TCM is effective in treating DR,the topical application of DR,especially intraocular injections,is not yet ***,we present a brief analysis of effective Chinese medicines for the treatment of *** effectiveness of local injections of TCM applied directly into the eyes holds promise as an effective treatment approach for DR.

关键词： Diabetic retinopathy Traditional Chinese medicine Genipin topical application Advanced glycation end products

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Comparative effects of insecticides with different mechanisms of action on Chrysoperla externa （Neuroptera＂ Chrysopidae）＂ Lethal, sublethal and dose-response effects

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Insect Science 2013年第6期20卷 743-752页

作者： Moises Joao Zotti Anderson Dionel Grutzmacher Isac Heres Lopes Guy Smagghe UGent-Crop Protection Ghent Oost-Vlaanderen Belgium UFPel - Phytosanitary Pelotas RS Brazil

The comprehensive knowledge that the delayed systemic and reproduction side effects can be even more deleterious than acute toxicity, has caused a shift in focus toward sublethal effects assessment on physiology and behavior of beneficial insects. In this study, we assessed the risks posed by some insecticides with different mode of action through lethal and delayed systemic sublethal effects on the pupation, adult emergence, and repro- duction of the chrysopid Chrysoperla externa （Hagen, 1861; Neuroptera： Chrysopidae）, an important predator in pest biological control. The maximum field recommended dose （MFRD） and twice （2xMFRD） for chlorantraniliprole, tebufenozide, and pyriproxyfen were harmless to C. externa. In contrast, all the tested chitin synthesis inhibitors （CSIs） were highly detrimental to the predator, despite of their lack of acute lethal toxicity. There- fore, the safety assumed by using IGRs toward beneficial insects is not valid for chrysopids. Dose-response data showed that although all CSIs have a similar mechanism of action, the relative extent of toxicity may differ （novaluron 〉 lufenuron 〉 teflubenzuron）. For CSIs, the delayed systemic effects became obvious at adult emergence, where the predicted no observable effect dose （NOED） was 1/2 048 of the MFRD for novaluron （0.085 ng/insect）, and 1/256 of the MFRD for both lufenuron （0.25 ng/insect） and teflubenzuron （0.6 ng/insect）. Finally, this work emphasized the significance of performing toxicity risk assessments with an adequate posttreatment period to avoid underestimating the toxicities of insecticides, as the acute lethal toxicity assays may not provide accurate information regarding the long-range effects of hazardous compounds.

关键词： Chrysoperla externa dose-response effects ecotoxicology IGRs insecti-cide risk assessment topical application

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Prevention of late complications with coverage agents in endoscopic resection of colorectal lesions: Current landscape in gastrointestinal endoscopy

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World Journal of Gastroenterology 2021年第15期27卷 1563-1568页

作者： Vicente Lorenzo-Zúñiga Marco Bustamante-Balén Vicente Pons-Beltrán Endoscopy Unit Department of GastroenterologyHospital Universitari i Politècnic La FeValencia 46026Spain Digestive Diseases Department La Fe Polytechnic University HospitalValencia 46026Spain

Endoscopic removal of large(≥20 mm)non-pedunculated colorectal lesions(LNPCLs)may result in major adverse events,such as delayed bleeding(DB)and delayed perforation(DP),despite closure of the mucosal defects with *** application of a coverage agent refers to the creation of a shield with a biocompatible medical device(tissue or hydrogel)with proven bioactive *** of the eschar after endoscopic resection provides shielding protection to prevent delayed *** aim of the present review was to systematically collect and review the currently available literature regarding the prevention of DB and DP with coverage agents after endoscopic mucosal resection or endoscopic submucosal dissection of LNPCLs.

关键词： Large colorectal lesions Delayed bleeding topical application Endoscopic mucosal resection Endoscopic submucosal dissection

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Localized,non-viral delivery of nucleic acids:Opportunities,challenges and current strategies

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Asian Journal of Pharmaceutical Sciences 2015年第3期10卷 159-175页

作者： Oliver Germershaus Kira Nultsch Institute for Pharma Technology School of Life SciencesUniversity of Applied Sciences and Arts Northwestern SwitzerlandGründenstrasse 40CH 4132MuttenzSwitzerland

Localized delivery of drugs is an emerging field both with regards to drug delivery during disease as well as in tissue *** significant achievements made in the last decades,the efficient delivery of proteins and peptides remains challenging,especially in cases requiring long-term release of proteins after *** localized delivery of nucleic acids(NA)represents an interesting alternative due to higher physicochemical stability of NA,increased efficiency by harnessing cells as bioreactors for the production of required proteins and improved versatility with regards to expression of specific proteins through plasmid DNA or repression of gene products through ***,unlike most proteins and peptides,NA must be delivered to the cytoplasm or nucleus to be efficacious,resulting in significant delivery *** herein describe frequently used non-viral vectors for the delivery of NA including polyplexes,lipoplexes and lipopolyplexes and summarize recent developments in the field of nucleic acid delivery systems for local application based on hydrogels,solid scaffolds and physical delivery *** challenges associated with the different approaches are identified and options to address these challenges are discussed.

关键词： Gene delivery topical application Tissue engineering Controlled release SiRNA DNA

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