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Advanced optical methods and materials for fabricating 3D tissue scaffolds

Light(Advanced Manufacturing) 2022年第3期3卷 28-59页

作者： Xiaobo Li Wanping Lu Xiayi Xu Yintao Wang Shih-Chi Chen Department of Mechanical and Automation Engineering The Chinese University of Hong KongShatinN.T.Hong Kong SARChina Centre for Perceptual and Interactive Intelligence Building 17W17 Science Park West AvenueHong Kong Science ParkPak Shek KokN.T.Hong Kong SARChina

Three-dimensional(3D)printing,also known as additive manufacturing(AM),has undergone a phase of rapid development in the fabrication of customizable and high-precision *** to the advancements in 3D printing technologies,it is now a reality to print cells,growth factors,and various biocompatible materials altogether into arbitrarily complex 3D scaffolds with high degree of structural and functional similarities to the native tissue ***,with overpowering advantages in molding efficiency,resolution,and a wide selection of applicable materials,optical 3D printing methods have undoubtedly become the most suitable approach for scaffold fabrication in tissue engineering(TE).In this paper,we first provide a comprehensive and up-to-date review of current optical 3D printing methods for scaffold fabrication,including traditional extrusion-based processes,selective laser sintering,stereolithography,and two-photon polymerization ***,we review the optical design,materials,and representative applications,followed by fabrication performance *** metrics include fabrication precision,rate,materials,and application ***,we summarize and compare the advantages and disadvantages of each technique to guide readers in the optics and TE communities to select the most fitting printing approach under different application scenarios.

关键词： 3D printing tissue scaffolds Optical fabrication

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AB085.E-beam sterilization of recombinant human collagen-phosphorylcholine corneal implants for transplantation

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Annals of Eye Science 2018年第1期 491-491页

作者： Fiona Simpson Joel Edin Mohammed Mirazol Islam Oleksiy Buznyk Monika Ljunggren Kozak Aneta Liszka Kim Merrett Håkan Per Fagerholm Gustafsson May Griffith Maisonneuve-Rosemont Hospital Research Centre and Department of Ophthalmology University of MontrealMontrealQuébecCanada

Background:The sterilization of corneal implants composed of carbodiimide crosslinked recombinant human collagen type III(RHCIII)and phosphorylcholine polymers(RHCIII-MPC)is constrained by the biochemical properties of *** human trials used 1%chloroform in 0.1 M phosphate buffered saline(C-PBS),but require a stringent wash procedure with antibiotics to remove the *** with gamma or electron-beam(e-beam)allows a chemical-free sterilization method,but may result in crosslinking or ***,electron-beam irradiation is evaluated as a sterilization method for RHCIII-MPC ***:Dose-finding study:RHCIII-MPC were cast in round,350µm thick,12 mm diameter molds for corneal implants and 0.5 mm thick dumbbell-shaped molds for mechanical *** hydrogels received an irradiation dose of 17,19,or 21 kGy and unirradiated controls were stored in C-PBS,n=3 per *** hydrogels were tested for sterility and endotoxin,optical and mechanical properties,biodegradation,free radicals,and cell *** evaluation in rabbits:RHCIII-MPC implants were e-beamed at 17 kGy or kept in *** implant from each group was implanted into the right cornea of each rabbit by deep anterior lamellar keratoplasty,n=4 animals per *** underwent preoperative and 6-month post-operative in vivo confocal microscopy(IVCM)to check nerve count and ingrowth of *** grafts and controls were assessed via histology and ***:Dose finding study:hydrogels were sterile at all irradiation doses with no evidence of free *** were no significant differences in optical or mechanical properties between the treatment groups and *** hydrogels supported cell *** 19 and 21 kGy implants had high collagenase degradation for 21 hours until they stabilized,whereas the 17 kGy and C-PBS implants had gradual degradation until 48 *** results:the rabbits did not experience post-surgica

关键词： Cornea collagen tissue scaffolds implant regenerative medicine

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