Advanced optical methods and materials for fabricating 3D tissue scaffolds

作     者：Xiaobo Li Wanping Lu Xiayi Xu Yintao Wang Shih-Chi Chen 

作者机构：Department of Mechanical and Automation EngineeringThe Chinese University of Hong KongShatinN.T.Hong Kong SARChina Centre for Perceptual and Interactive IntelligenceBuilding 17W17 Science Park West AvenueHong Kong Science ParkPak Shek KokN.T.Hong Kong SARChina 

出 版 物：《Light(Advanced Manufacturing)》 (光（先进制造）（英文）)

年 卷 期：2022年第3卷第3期

页      面：28-59页

学科分类：08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：This work was supported by the Innovation and Technology Commission(ITC)(ITS/178/20FP) Centre for Perceptual and Interactive Intelligence(CPII)Ltd under the Innovation and Technology Fund 

主　　题：3D printing Tissue scaffolds Optical fabrication 

摘      要：Three-dimensional(3D)printing,also known as additive manufacturing(AM),has undergone a phase of rapid development in the fabrication of customizable and high-precision *** to the advancements in 3D printing technologies,it is now a reality to print cells,growth factors,and various biocompatible materials altogether into arbitrarily complex 3D scaffolds with high degree of structural and functional similarities to the native tissue ***,with overpowering advantages in molding efficiency,resolution,and a wide selection of applicable materials,optical 3D printing methods have undoubtedly become the most suitable approach for scaffold fabrication in tissue engineering(TE).In this paper,we first provide a comprehensive and up-to-date review of current optical 3D printing methods for scaffold fabrication,including traditional extrusion-based processes,selective laser sintering,stereolithography,and two-photon polymerization ***,we review the optical design,materials,and representative applications,followed by fabrication performance *** metrics include fabrication precision,rate,materials,and application ***,we summarize and compare the advantages and disadvantages of each technique to guide readers in the optics and TE communities to select the most fitting printing approach under different application scenarios.