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Effects of moxibustion or moxa smoke on serum lipids and carotid plaque stability in atherosclerotic mice

Journal of Traditional Chinese Medical Sciences 2020年第3期7卷 325-332页

作者： Rui Zhang Lue Ha Rui He Yueping Huang Hao Wang Baixiao Zhao School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing100029China

Objective:To observe the effects of moxibustion or moxa smoke on serum lipids,aorta and liver pathology,and carotid plaque stability in ***:Fifty-four 8-week-old ApoE^-/- mice were randomly divided into three groups(untreated,moxibustion,and moxa smoke)and received a high-fat *** wild-type C57 BL/6 mice of the same age were used as *** intervention(none,moxibustion between the nipples,or 10 e15 mg/m^3 moxa smoke)was applied to restrained mice 20 min per day,six days per week,for 12 *** the end of the experimental period,we measured serum lipids and apolipoprotein,stained thoracic aortas and livers to observe pathological changes,and used immunohistochemical staining to assess the levels of a-smooth muscle actin,CD68,tumor necrosis factor-α,nuclear transcription factor-κB,and P38 mitogen-activated protein *** also measured the levels of matrix metalloproteinase-2 and 9 and tissue metalloproteinase ***:After 12 weeks,lipid metabolism disorder and atherosclerotic plaques were observed in the ApoE^-/- *** or moxa smoke reduced the levels of serum total cholesterol,triglycerides,low density lipoprotein,and very low density lipoprotein but did not affect the levels of high density lipoprotein,apolipoprotein A1,or oxidized low density *** or moxa smoke suppressed pathological changes in thoracic aortas and livers,increased fiber cap thickness,the fiber cap thickness/intimal medial thickness ratio,and collagen area percentage,and reduced extracellular *** with moxibustion or moxa smoke increased a-smooth muscle actin and reduced CD68 and the vulnerability index,suppressed tumor necrosis factor-α and nuclear transcription factor-κB expression,and did not affect P38 mitogen-activated protein kinase *** lowered the levels of matrix metalloproteinase-2 and 9 and increased those of tissue metalloproteinase ***:Moxibustion or moxa smo

关键词： Atherosclerosis Matrix metalloproteinase Vulnerability index tissue metalloproteinase inhibitor

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