Effects of moxibustion or moxa smoke on serum lipids and carotid plaque stability in atherosclerotic mice

作     者：Rui Zhang Lue Ha Rui He Yueping Huang Hao Wang Baixiao Zhao Rui Zhang;Lue Ha;Rui He;Yueping Huang;Hao Wang;Baixiao Zhao

作者机构：School of Acupuncture-Moxibustion and TuinaBeijing University of Chinese MedicineBeijing100029China 

出 版 物：《Journal of Traditional Chinese Medical Sciences》 (中医科学杂志（英文）)

年 卷 期：2020年第7卷第3期

页      面：325-332页

学科分类：1007[医学-药学(可授医学、理学学位)] 1005[医学-中医学] 1002[医学-临床医学] 100512[医学-针灸推拿学] 10[医学] 

基　　金：the National Natural Science Foundation of China(numbers 81874503 and 81574068) 

主　　题：Atherosclerosis Matrix metalloproteinase Vulnerability index Tissue metalloproteinase inhibitor 

摘      要：Objective:To observe the effects of moxibustion or moxa smoke on serum lipids,aorta and liver pathology,and carotid plaque stability in ***:Fifty-four 8-week-old ApoE^-/- mice were randomly divided into three groups(untreated,moxibustion,and moxa smoke)and received a high-fat *** wild-type C57 BL/6 mice of the same age were used as *** intervention(none,moxibustion between the nipples,or 10 e15 mg/m^3 moxa smoke)was applied to restrained mice 20 min per day,six days per week,for 12 *** the end of the experimental period,we measured serum lipids and apolipoprotein,stained thoracic aortas and livers to observe pathological changes,and used immunohistochemical staining to assess the levels of a-smooth muscle actin,CD68,tumor necrosis factor-α,nuclear transcription factor-κB,and P38 mitogen-activated protein *** also measured the levels of matrix metalloproteinase-2 and 9 and tissue metalloproteinase ***:After 12 weeks,lipid metabolism disorder and atherosclerotic plaques were observed in the ApoE^-/- *** or moxa smoke reduced the levels of serum total cholesterol,triglycerides,low density lipoprotein,and very low density lipoprotein but did not affect the levels of high density lipoprotein,apolipoprotein A1,or oxidized low density *** or moxa smoke suppressed pathological changes in thoracic aortas and livers,increased fiber cap thickness,the fiber cap thickness/intimal medial thickness ratio,and collagen area percentage,and reduced extracellular *** with moxibustion or moxa smoke increased a-smooth muscle actin and reduced CD68 and the vulnerability index,suppressed tumor necrosis factor-α and nuclear transcription factor-κB expression,and did not affect P38 mitogen-activated protein kinase *** lowered the levels of matrix metalloproteinase-2 and 9 and increased those of tissue metalloproteinase ***:Moxibustion or moxa smo