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Activating proper inflammation for wound-healing acceleration via mesoporous silica nanoparticle tissue adhesive

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Nano Research 2020年第2期13卷 373-379页

作者： Zhao Pan Kai-Run Zhang Huai-Ling Gao Yong Zhou Bei-Bei Yan Chi Yang Zhi-Yuan Zhang Liang Dong Si-Ming Chen Rui Xu Duo-Hong Zou Shu-Hong Yu Division of Nanomaterials&Chemistry Hefei National Laboratory for Physical Sciences at the MicroscaleCAS Center for Excellence in NanoscienceHefei Science Center of CASCollaborative Innovation Center of Suzhou Nano Science and Techology Department of ChemistryUniversity of Science and Technology of ChinaHefei 230026China Department of Oral Surgery Ninth People's HospitalShanghai Jjiao Tong University School of MedicineShanghai Key Laboratory of StomatologyNational Clinical Research Center of StomatologyShanghai 200011China Key Laboratory of Oral Diseases Research ofAnhui Province Stomatologic Hospital&CollgeAnhui Medical University Heifei 230032China

Efficient initiation and resolution of inflammation are crucial for wound ***,with using tissue adhesives for wound repair,patients occasionally suffered from delayed healing process because slow elimination of those exogenous adhesives generally leads to chronic *** the demand for minimal invasive therapy continues to rise,desire for adhesive materials that can effectively reconnect surgical gaps and promote wound regeneration becomes increasingly ***,by exploiting the inherent porous structure and performance of adhesion to tissue of mesoporous silica nanoparticles(MSNs),we demonstrate a tissue adhesive that can elicit acute inflammatory response and get eliminated after tissue *** formation of nanocomposites in wound gaps,the injured tissues can get reconnected *** resultant accelerated healing process verifty that the strategy of exploiting unique properties of nanomaterials can effectively promote inflammation resolution and wound *** design strategy will inspire more innovative tissue adhesives for clinical applications.

关键词： mesoporous nanoparticle tissue adhesive wound repair inflammation accelerated healing

Natural biopolymers derived hydrogels with injectable,self-healing,and tissue adhesive abilities for wound healing

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Nano Research 2023年第2期16卷 2798-2807页

作者： Bin Kong Rui Liu Yi Cheng Xiaodong Cai Junying Liu Dagan Zhang Hui Tan Yuanjin Zhao Department of Rheumatology and Immunology The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210002China Respiratory department Shenzhen Children's HospitalShenzhen 518038China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325001China

Developing a biocompatible and multifunctional adhesive hydrogel with injectability and self-healing ability for promoting wound healing is highly anticipated in various clinical *** this paper,we present a novel natural biopolymer-derived hydrogel based on the aldehyde-modified oxidized guar gum(OGG)and the carboxymethyl chitosan(CMCS)for efficiently improving wound healing with the encapsulation of vascular endothelial growth factor(VEGF).As the hydrogels are synthesized via the dynamically reversible Schiff base linkages,it is imparted with excellent self-healing ability and good shear thinning behavior,which make the hydrogel be easily and conveniently injected through a ***,the physiochemical properties,including porous structure,mechanical strength and swelling ratio of the hydrogel can be well controlled by regulating the concentrations of the ***,the hydrogel can attain strong adhesion to the tissues at physiological temperature based on the Schiff base between the aldehyde group on the hydrogel and the amino group on the *** on these features,we have demonstrated that the VEGF encapsulated hydrogel can adhere tightly to the defect tissue and improve wound repair in the rat model of defected skin by promoting cell proliferation,angiogenesis,and collagen *** results indicate that the multifunctional hydrogel is with great scientific significance and broad clinical application prospects.

关键词： hydrogel self-healing injectability tissue adhesive wound healing

A soft tissue adhesive based on aldehyde-sodium alginate and amino-carboxymethyl chitosan preparation through the Schiff reaction

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Frontiers of Materials Science 2017年第3期11卷 215-222页

作者： Yu WU Liu YUAN Nai-an SHENG Zi-qi GU Wen-hao FENG Hai-yue YIN Yosry MORSI Xiu-mei MO Key Laboratory of Textile Science & Technology (Ministry of Education) College of Chemistry Chemical Engineering and Biotechnology Donghua University Shanghai 201620 China Faculty of Engineering and Industrial Sciences Swinburne University of Technology Hawthorn Vic 3122 Australia Shandong International Biotechnology Park Development Co. Ltd. Yantai 264003 China

Sodium alginate and carboxymethyl chitosan have been extensively applied in tissue engineering and other relative fields due to their low price and excellent biocompatibility. In this paper, we oxidized sodium alginate with sodium periodate to convert 1,2-hydroxyl groups into aldehyde groups to get aldehyde-sodium alginate （A- SA）. Carboxymethyl chitosan was modified with ethylenediamine （ED） in the presence of water-soluble N-（3-Dimethylaminopropyl）-N＇-ethylcarbodiimide hydrochloride （EDC） to introduce additional amino groups to get amino-carboxymethyl chitosan （A-CS）. Upon mixing the A-SA and A-CS aqueous solutions together, a gel rapidly formed based on the Schiff＇s base reaction between aldehyde groups in A-SA and amino groups in A-CS. FTIR analysis confirmed the characteristic peak of Schiff＇s base group in the hydrogel. It was confirmed that the gelation time be dependent on the aldehyde group content in A-SA and amino group content in A-CS. The fasted hydrogel formation takes place within 10 min. The data of bonding strength and cytotoxicity measurement also showed that the hydrogel had good adhesion and biocompatibility. All these results support that this gel has the potential as soft tissue adhesive.

关键词： oxidized sodium alginate amino-carboxymethyl chitosan tissue adhesive Schiff's base

Evaluation of hydrogels for soft tissue adhesives in vitro and in vivo analyses

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Frontiers of Materials Science 2018年第1期12卷 95-104页

作者： Liu YUAN Wenshuai FAN Linyingjun HAN Changan GUO Zuoqin YAN Meifang ZHU Xiumei MO State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and Engineering Donahua Universitv. Shanahai 201620. China Biomaterials and tissue Engineering Lab College of Chemistry Chemical Engineering and Biotechnology Donghua University Shanghai 201620 China Department of Orthopedics Zhongshan Hospital of Fudan Universily 180 FengUn Road Shanghai 200032 China Shandong International Biotechnology Park Development Co. Ltd. Yantai 264003 China

In this study, natural materials （sodium alginate, dextran, gelatin and carboxymethyl chitosan） were modified to get aldehyde components and amino components. Upon mixing the two-component solutions together, four kinds of Schiff base hydrogels formed successfully within 5-300 s and could seal the wound tissue. The cytotoxicity tests of hydrogel extraction solution confirmed that the hydrogels are nontoxic materials. The adhesive ability was evaluated in vivo by measuring the adhesive strength after sealing the skin incisions on the back of rats. All the hydrogels showed higher adhesive strength than that of commercial fibrin glue and the blank control. The histological staining observation by hematoxylin and eosin staining （HE） and Masson＇s trichrome staining （MTC） methods suggested that the hydrogels had good biocompatibility and biodegradation in vivo. They have only normal initial inflammation to skin tissue and could improve the formation of new collagen in the incision section. So, the prepared hydrogels were both safe and effective tissue adhesive, which had the great potentials to be used as skin tissue adhesive.

关键词： Schiff's base injectable hydrogels tissue adhesive

A novel bioactive polyurethane with controlled degradation and L-Arg release used as strong adhesive tissue patch for hemostasis and promoting wound healing

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Bioactive Materials 2022年第11期7卷 471-487页

作者： Faxing Zou Yansen Wang Yudong Zheng Yajie Xie Hua Zhang Jishan Chen M.Irfan Hussain Haoye Meng Jiang Peng School of Material Science&Engineering University of Science and Technology BeijingBeijing10083China The First Affiliated Hospital of Chongqing Medical University China Beijing Key Lab of Regenerative Medicine in Orthopedics Key Laboratory of Musculoskeletal Trauma&War InjuriesPLA Institute of OrthopedicsChinese PLA General HospitalBeijingChina

Effective strategy of hemostasis and promoting angiogenesis are becoming increasingly urgent in modern medicine due to millions of deaths caused by tissue damage and inflammation. The tissue adhesive has been favored as an optimistic and efficient path to stop bleeding, while, current adhesive presents limitations on wound care or potential degradation safety in clinical practice. Therefore, it is of great clinical significance to construct multifunctional wound adhesive to address the issues. Based on pro-angiogenic property of L-Arginine (L-Arg), in this study, the novel tissue adhesive (G-DLPUs) constructed by L-Arg-based degradable polyurethane (DLPU) and GelMA were prepared for wound care. After systematic characterization, we found that the G-DLPUs were endowed with excellent capability in shape-adaptive adhesion. Moreover, the L-Arg released and the generation of NO during degradation were verified which would enhance wound healing. Following the in vivo biocompatibility was verified, the hemostatic effect of the damaged organ was tested using a rat liver hemor-rhage model, from which reveals that the G-DLPUs can reduce liver bleeding by nearly 75% and no obvious inflammatory cells observed around the tissue. Moreover, the wound care effect was confirmed in a mouse full-thickness skin defect model, showing that the hydrogel adhesive significantly improves the thickness of newly formed dermis and enhance vascularization (CD31 staining). In summary, the G-DLPUs are promising candidate to act as multifunctional wound care adhesive for both damaged organ and trauma.

关键词： tissue adhesive Pro-angiogenic Biodegradable safety Arginine-based polyurethane Hemostasis

Sutureless vascular anastomotic approaches and their potential impacts

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Bioactive Materials 2024年第8期38卷 73-94页

作者： Joseph G.Ribaudo Kevin He Sarah Madira Emma R.Young Cameron Martin Tingying Lu Justin M.Sacks Xiaowei Li Division of Plastic and Reconstructive Surgery Department of SurgeryWashington University in St.LouisMO63110USA Department of Plastic Surgery Johns Hopkins School of MedicineBaltimoreMD21287USA

Sutureless anastomotic devices present several advantages over traditional suture anastomosis,including expanded global access to microvascular surgery,shorter operation and ischemic times,and reduced ***,their adaptation for arterial use remains a *** review aims to provide a comprehensive overview of sutureless anastomotic approaches that are either FDA-approved or under *** approaches include extraluminal couplers,intraluminal devices,and methods assisted by lasers or vacuums,with a particular emphasis on tissue *** analyze these devices for artery compatibility,material composition,potential for intimal damage,risks of thrombosis and restenosis,and complications arising from their deployment and ***,we discuss the challenges faced in the development and clinical application of sutureless anastomotic ***,a sutureless anastomotic device or technique should eliminate the need for vessel eversion,mitigate thrombosis through either biodegradation or the release of antithrombotic drugs,and be easily deployable for broad *** transformative potential of sutureless anastomotic approaches in microvascular surgery highlights the necessity for ongoing innovation to expand their applications and maximize their benefits.

关键词： Vascular Anastomotic device tissue adhesive Patency OUTLINE

Endoscopic treatment of bleeding gastric ulcer causing gastric wall necrosis:A case report

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1203-1207页

作者： Wei-Feng Li Ruo-Yu Gao Jing-Wen Xu Xi-Qiu Yu Department of Gastroenterology Shenzhen Luohu People’s HospitalShenzhen 518020Guangdong ProvinceChina

BACKGROUND Gastric wall necrosis is a rare complication of endoscopic treatment for bleeding gastric ulcer,which may exacerbate the patient’s condition once it occurs and may even require surgical intervention for *** SUMMARY A 59-year-old man was admitted to our department with *** revealed a giant ulcer in the gastric antrum with a visible vessel in its center,which was treated with sclerosants and tissue glue injection and resulted in necrosis of the gastric *** Injection of sclerosants and tissue glue may lead to gastric wall necrosis,which is a serious ***,before administering this treatment to patients,we should consider other more effective methods of hemostasis to avoid gastric wall necrosis.

关键词： Bleeding gastric ulcer Sclerotherapy Lauromacrogol tissue adhesive Gastric wall necrosis Case report