Activating proper inflammation for wound-healing acceleration via mesoporous silica nanoparticle tissue adhesive
作者机构：Division of Nanomaterials&ChemistryHefei National Laboratory for Physical Sciences at the MicroscaleCAS Center for Excellence in NanoscienceHefei Science Center of CASCollaborative Innovation Center of Suzhou Nano Science and Techology Department of ChemistryUniversity of Science and Technology of ChinaHefei 230026China Department of Oral SurgeryNinth People's HospitalShanghai Jjiao Tong University School of MedicineShanghai Key Laboratory of StomatologyNational Clinical Research Center of StomatologyShanghai 200011China Key Laboratory of Oral Diseases Research ofAnhui ProvinceStomatologic Hospital&CollgeAnhui Medical University Heifei 230032China
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2020年第13卷第2期
页 面：373-379页
核心收录：
学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学]
基 金：This work was supported by the National Natural Science Foundation of China(Nos.51732011,21431006,21761132008,51471157,21401183,and 21771168) the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(No.21521001) Key Research Program of Frontier Sciences,CAS(No.QYZDJ-SSW-SLH036) the National Basic Research Program of China(No.2014CB931800) the Users with Excellence and Scientific Research Grant of Hefei Science Center of CAS(No.2015HSC-UE007) the Youth Innovation Promotion Association of CAS(No.2014298)
主 题：mesoporous nanoparticle tissue adhesive wound repair inflammation accelerated healing
摘 要：Efficient initiation and resolution of inflammation are crucial for wound ***,with using tissue adhesives for wound repair,patients occasionally suffered from delayed healing process because slow elimination of those exogenous adhesives generally leads to chronic *** the demand for minimal invasive therapy continues to rise,desire for adhesive materials that can effectively reconnect surgical gaps and promote wound regeneration becomes increasingly ***,by exploiting the inherent porous structure and performance of adhesion to tissue of mesoporous silica nanoparticles(MSNs),we demonstrate a tissue adhesive that can elicit acute inflammatory response and get eliminated after tissue *** formation of nanocomposites in wound gaps,the injured tissues can get reconnected *** resultant accelerated healing process verifty that the strategy of exploiting unique properties of nanomaterials can effectively promote inflammation resolution and wound *** design strategy will inspire more innovative tissue adhesives for clinical applications.
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