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Synergistic effect between cryptotanshinone and antibiotics in oral pathogenic bacteria

Advances in Bioscience and Biotechnology 2013年第2期4卷 283-294页

作者： Jeong-Dan Cha Mi-Ran Jeong Kyung-Min Choi Jeong-Hye Park Su-Mi Cha Kyung-Yeol Lee Department of Natural Products Research Institute of Jinan Red Ginseng Jinan South Korea Department of Nursing Dong-eui University Busan South Korea Department of Oral Microbiology and Institute of Oral Bioscience Chonbuk National University Jeonju South Korea

Cryptotanshinone (CT), a major tanshinone of medicinal plant Salvia miltiorrhiza Bunge, demonstrated effective in vitro antibacterial activity against all oral bacteria tested in this experiment. The antibacterial activities of CT against oral bacteria were assessed using the checkerboard and time-kill methods to evaluate the synergistic effects of treatment with ampicillin or gentamicin. The CT was determined against oral pathogenic bacteria with MIC and MBC values ranging from 0.5 to 16 and 1 to 64 μg/mL;for am- picillin from 0.0313 to 16 and 0.125 to 32 μg/mL;for gentamicin from 2 to 256 and 4 to 512 μg/mL respectively. The range of MIC50 and MIC90 were 0.0625 - 8 μg/mL and 1 - 64 μg/mL, respectively. The combination effects of CT with antibiotics were synergistic (FIC index time-kill study showed that the growth of the tested bacteria was completely attenuated after 3 - 6 h of treatment with the 1/2 MIC of CT, regardless of whether it was administered alone or with ampicillin or gentamicin. The results suggest that CT could be employed as a natural antibacterial agent against cariogenic and periodontopathogenic bac- teria.

关键词： Cryptotanshinone Antibacterial Activity Oral Bacteria Checker Board Method time-kill Method Synergistic Effect

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Combination of Acacetin with Antibiotics against Methicillin Resistant <i>Staphylococcus aureus</i>Isolated from Clinical Specimens

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Advances in Bioscience and Biotechnology 2014年第4期5卷 398-408页

作者： Jeong-Dan Cha Sung-Mi Choi Jeong Hye Park Department of Dental Hygiene Daegu Health College Daegu South Korea Department of Nursing Dong-eui University Bu-san South Korea Department of Research Development Institute of Jinan Red Ginseng Jinan South Korea

Methicillin-restitant Staphylococcus aureus (MRSA) is very dangerous bacteria and one of the most feared nosocomial germs. In this study, acacetin was evaluated against 20 clinical isolates of MRSA, either alone or in combination with antibiotics. The acacetin exhibited a good activity against isolates MRSA with MICs/MBCs ranged between 10-80/20-160 μg/mL, for ampicillin 64-1024/128-2048 μg/mL, and for oxacillin 8-32/16-64 μg/mL. The combination of acacetin plus oxacillin or ampicillin was reduced by ≥4-fold against isolates MRSA tested, evidencing a synergistic effect as defined by a FICI of ≤0.5. Furthermore, a time-kill study evaluating the growth of the tested bacteria was completely attenuated after 2-5 h of treatment with the 1/2 MIC of acacetin, regardless of whether it was administered alone or with oxacillin (1/2 MIC) or ampicillin (1/2 MIC). In conclusion, acacetin exerted synergistic effects when administered with oxacillin or ampicillin and the antibacterial activity and resistant regulation of acacetin against clinical isolates of MRSA might be useful in controlling MRSA infections.

关键词： Acacetin Methicillin-Resistant Staphylococcus aureus Minimum Inhibitory Concentrations Minimum Bactericidal Concentrations time-kill Curves Fractional Inhibitory Concentration

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