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Dietary supplementation of 25-hydroxycholecalciferol increases tibial mass by suppression bone resorption in meat ducks

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Animal Nutrition 2020年第4期6卷 467-479页

作者： Huaiyong Zhang Qiufeng Zeng Shiping Bai Jianping Wang Xuemei Ding Yue Xuan Zhuowei Su Gergory S.Fraley Bing Yao Keying Zhang Institute of Animal Nutrition Key Laboratory for Animal Disease-Resistance Nutrition of ChinaMinistry of EducationSichuan Agricultural UniversityChengduSichuan611130China Biology Department Hope CollegeHolland49423USA DSM(China)Ltd. PuDong New AreaShanghai201203China

Leg problems often result from the rapid weight gain and poor bone quality in modern ducks,leading to a high risk of fractures and continuous *** hypothesized that improving bone quality in combination with delaying weight gain via a low nutrient density(LND)diet probably reverses these skeletal *** indicated that 25-hydroxycholecalciferol(25-OH-D3),a vitamin D3 metabolite,is effective in treating bone-related ***,Exp.1 evaluated the effects of 25-OH-D3 on tibial mass of meat *** meat ducklings were fed a standard nutrient density diet(containing a regular vitamin regimen)without or with 25-OH-D3 at 0.069 mg/kg for 35 *** results showed that 25-OH-D3 supplementation improved the mineral content,microarchitecture and mechanical properties of tibias,and this companied by a decreased serum bone resorption marker and a concomitant decrement in osteoclast-specific marker genes ***,Exp.2 was conducted to examine the impacts of 25-OH-D3 incorporating an LND diet on tibial quality of ducks under 2 different vitamin regimens(regular and high).Ducklings were allocated to a 2*2 factorial arrangement with 2 kinds of vitamin premixes and without or with 25-OH-D3 at 0.069 mg/kg in LND *** high premix had higher levels of all vitamins except biotin than the regular *** results demonstrated that high vitamin diets exhibited more significant effects than regular vitamin diets on inhibiting bone turnover and increasing minerals *** mineral content,microarchitecture,and strength of birds under the regular vitamin regimen were increased by 25-OH-D3 supplementation;However,these positive effects were not observed in ducks under the high vitamin *** conclude,25-OH-D3 supplementation improves tibial mass by suppressing osteoclast-mediated bone resorption in meat ducks,and this positive impact only was observed in regular but not high vitamin regimen when birds fed an LND diet.

关键词： Vitamin D_(3)metabolites Vitamin Bone turnover tibial mass Meat duck

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25-hydroxycholecalciferol reverses heat induced alterations in bone quality in finisher broilers associated with effects on intestinal integrity and inflammation

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Journal of Animal Science and Biotechnology 2022年第2期13卷 499-519页

作者： Huaiyong Zhang Maryam Majdeddin Djoere Gaublomme Bernard Taminiau Matthieu Boone Dirk Elewaut George Daube Iván Josipovic Keying Zhang Joris Michiels Laboratory for Animal Nutrition and Animal Product Quality Department of Animal Sciences and Aquatic EcologyGhent University9000 GhentBelgium Key laboratory of Animal Disease-resistant Nutrition Ministry of EducationInstitute of Animal NutritionSichuan Agricultural UniversityYa’an 611130SichuanChina Unit Molecular Immunology and Inflammation VIB Center for Inflammation ResearchGhent University and Department of RheumatologyGhent University Hospital9000 GhentBelgium Department of Food Sciences-Microbiology University of Liège4000 LiègeBelgium Ghent University Centre for X-ray Tomography(UGCT) Ghent University9000 GhentBelgium Department of Physics and Astronomy Radiation Physics Research GroupGhent University9000 GhentBelgium

Background:Alterations in ambient temperature have been associated with multiple detrimental effects on broilers such as intestinal barrier disruption and dysbiosis resulting in systemic *** and 25-hydroxycholecalciferol(25-OH-D_(3))have shown to play a negative and positive role,respectively,in the regulation of bone *** the potential of 25-OH-D_(3)in alleviating heat induced bone alterations and its mechanisms was ***:Heat stress(HS)directly induced a decrease in tibia material properties and bone mass,as demonstrated by lower mineral content,and HS caused a notable increase in intestinal *** with dietary 25-OH-D_(3)reversed the HS-induced bone loss and barrier *** suffering from HS exhibited dysbiosis and increased expression of inflammatory cytokines in the ileum and bone marrow,as well as increased osteoclast number and *** changes were prevented by dietary 25-OH-D_(3)***,dietary 25-OH-D_(3)addition decreased abundance of B-and T-cells in blood,and the expression of inflammatory cytokines,especially TNF-α,in both the ileum and bone marrow,but did not alter the diversity and population or composition of major bacterial *** regard to bone remodeling,dietary 25-OH-D_(3)supplementation was linked to a decrease in serum C-terminal cross-linked telopeptide of type I collagen reflecting bone resorption and a concomitant decrement in osteoclast-specific marker genes expression(*** K),whereas it did not apparently change serum bone formation markers during ***:These data underscore the damage of HS to intestinal integrity and bone health,as well as that dietary 25-OH-D_(3)supplementation was identified as a potential therapy for preventing these adverse effects.

关键词： Bone remodeling HS Inflammation Intestinal barrier tibial mass

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