Dietary supplementation of 25-hydroxycholecalciferol increases tibial mass by suppression bone resorption in meat ducks

作     者：Huaiyong Zhang Qiufeng Zeng Shiping Bai Jianping Wang Xuemei Ding Yue Xuan Zhuowei Su Gergory S.Fraley Bing Yao Keying Zhang Huaiyong Zhang;Qiufeng Zeng;Shiping Bai;Jianping Wang;Xuemei Ding;Yue Xuan;Zhuowei Su;Gergory S.Fraley;Bing Yao;Keying Zhang

作者机构：Institute of Animal NutritionKey Laboratory for Animal Disease-Resistance Nutrition of ChinaMinistry of EducationSichuan Agricultural UniversityChengduSichuan611130China Biology DepartmentHope CollegeHolland49423USA DSM(China)Ltd.PuDong New AreaShanghai201203China 

出 版 物：《Animal Nutrition》 (动物营养（英文版）)

年 卷 期：2020年第6卷第4期

页      面：467-479页

核心收录：

学科分类：090502[农学-动物营养与饲料科学] 0905[农学-畜牧学] 09[农学] 

基　　金：supported by the Modern Agri-industry Technology Research System(CARS-42-10) the 111 Project 

主　　题：Vitamin D_(3)metabolites Vitamin Bone turnover Tibial mass Meat duck 

摘      要：Leg problems often result from the rapid weight gain and poor bone quality in modern ducks,leading to a high risk of fractures and continuous *** hypothesized that improving bone quality in combination with delaying weight gain via a low nutrient density(LND)diet probably reverses these skeletal *** indicated that 25-hydroxycholecalciferol(25-OH-D3),a vitamin D3 metabolite,is effective in treating bone-related ***,Exp.1 evaluated the effects of 25-OH-D3 on tibial mass of meat *** meat ducklings were fed a standard nutrient density diet(containing a regular vitamin regimen)without or with 25-OH-D3 at 0.069 mg/kg for 35 *** results showed that 25-OH-D3 supplementation improved the mineral content,microarchitecture and mechanical properties of tibias,and this companied by a decreased serum bone resorption marker and a concomitant decrement in osteoclast-specific marker genes ***,Exp.2 was conducted to examine the impacts of 25-OH-D3 incorporating an LND diet on tibial quality of ducks under 2 different vitamin regimens(regular and high).Ducklings were allocated to a 2*2 factorial arrangement with 2 kinds of vitamin premixes and without or with 25-OH-D3 at 0.069 mg/kg in LND *** high premix had higher levels of all vitamins except biotin than the regular *** results demonstrated that high vitamin diets exhibited more significant effects than regular vitamin diets on inhibiting bone turnover and increasing minerals *** mineral content,microarchitecture,and strength of birds under the regular vitamin regimen were increased by 25-OH-D3 supplementation;However,these positive effects were not observed in ducks under the high vitamin *** conclude,25-OH-D3 supplementation improves tibial mass by suppressing osteoclast-mediated bone resorption in meat ducks,and this positive impact only was observed in regular but not high vitamin regimen when birds fed an LND diet.