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Hypothyroidism and Nonalcoholic Fatty Liver Disease:Pathophysiological Associations andTherapeutic Implications

Journal of Clinical and Translational Hepatology 2020年第3期8卷 347-353页

作者： Tomislav Kizivat Ivana Maric Dunja Mudri Ines Bilic Curcic Dragan Primorac Martina Smolic University of Osijek Faculty of MedicineOsijekCroatia University Hospital Osijek OsijekCroatia St Catherine Specialty Hospital Zagreb&ZabokCroatia University of Split School of Medicine SplitCroatia Eberly College of Science State CollegePenn State UniversityPAUSA The Henry C Lee College of Criminal Justice&Forensic Sciences University of New HavenWest HavenCTUSA University of Rijeka School of Medicine RijekaCroatia University of Osijek Faculty of Dental Medicine&Health OsijekCroatia

Nonalcoholic fatty liver disease(NAFLD)is a complex clinical entity which can be secondary to many other diseases including hypothyroidism,characterized by lowering of thyroid hormones and increased thyroid stimulating hormone(TSH).A lot of emerging data published recently advocates the hypothesis that hypothyroid induced NAFLD could be a separate clinical entity,even suggesting possible treatment options for NAFLD involving substitution therapy for hypothyroidism along with lifestyle *** addition,a whole new field of research is focused on thyromimetics in NAFLD/NASH treatment,currently in phase 3 clinical *** this critical review we summarized epidemiological and pathophysiological evidence linking these two clinical entities and described specific treatment options with the accent on promising new agents in NAFLD treatment,specifically thyroid hormone receptor(THR)agonist and its metabolites.

关键词： NAFLD MAFLD Hypothyroidism Metabolic syndrome thyromimetics

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Thyroid hormone analogues and derivatives:Actions in fatty liver

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World Journal of Hepatology 2014年第3期6卷 114-129页

作者： Maria Coppola Daniela Glinni Maria Moreno Federica Cioffi Elena Silvestri Fernando Goglia Department of Science and Technologies University of Sannio

Fatty liver or nonalcoholic fatty liver disease(NAFLD),a problem of increasing clinical significance and prevalence worldwide,is associated with increased risk for the development of cirrhosis and hepatocellular *** several therapeutic approaches can be used in the context of NAFLD,dietary and physical activities are still the most frequently used *** pharmacological agents show promising results although no conclusions can be drawn from recent clinical *** hormones[THs;thyroxine(T4)and3,3′,5-triiodo-L-thyronine(T3)]coordinate a diverse array of physiological events during development and lipid/energy homeostasis and have some potentially therapeutic actions which include inducing weight loss,and lowering plasma cholesterol levels and tissue *** thyroid hormones exert their physiological effects by binding to specific nuclear receptors[thyroid hormone receptors(TR)]of which the TRβisoform is liver specific and has been considered a putative target for the treatment of dyslipidemia and fatty *** view of this,the aim of the review is(1)to provide an overview of the action of T3 on lipid metabolism with implications for liver steatosis and(2)to provide an update on the current knowledge concerning the administration of TRβselective thyromimetics(GC-1 and MB07811),as well as of 3,5-diiodo-L-thyronine and its novel functional analogue TRC150094 in animal models of overweight and related disorders including primarily fatty liver.

关键词： Fatty liver Thyroid hormones thyromimetics 3,5-diiodo-L-thyronine Lipid metabolism

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