Hypothyroidism and Nonalcoholic Fatty Liver Disease:Pathophysiological Associations andTherapeutic Implications
作者机构：University of OsijekFaculty of MedicineOsijekCroatia University Hospital OsijekOsijekCroatia St Catherine Specialty HospitalZagreb&ZabokCroatia University of Split School of MedicineSplitCroatia Eberly College of ScienceState CollegePenn State UniversityPAUSA The Henry C Lee College of Criminal Justice&Forensic SciencesUniversity of New HavenWest HavenCTUSA University of Rijeka School of MedicineRijekaCroatia University of Osijek Faculty of Dental Medicine&HealthOsijekCroatia
出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)
年 卷 期：2020年第8卷第3期
页 面：347-353页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：funded by grant from Croatian Ministry of Science and Education dedicated to multi-year institutional funding of scientific activity at the J.J.Strossmayer University of Osijek Osijek Croatia—grant's number:IP-2019-MEFOS-10(to M.S.)
主 题：NAFLD MAFLD Hypothyroidism Metabolic syndrome Thyromimetics
摘 要：Nonalcoholic fatty liver disease(NAFLD)is a complex clinical entity which can be secondary to many other diseases including hypothyroidism,characterized by lowering of thyroid hormones and increased thyroid stimulating hormone(TSH).A lot of emerging data published recently advocates the hypothesis that hypothyroid induced NAFLD could be a separate clinical entity,even suggesting possible treatment options for NAFLD involving substitution therapy for hypothyroidism along with lifestyle *** addition,a whole new field of research is focused on thyromimetics in NAFLD/NASH treatment,currently in phase 3 clinical *** this critical review we summarized epidemiological and pathophysiological evidence linking these two clinical entities and described specific treatment options with the accent on promising new agents in NAFLD treatment,specifically thyroid hormone receptor(THR)agonist and its metabolites.
维普期刊数据库