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Effects of High Fluoride and Low Iodine on thyroid function in Offspring Rats

Journal of Integrative Agriculture 2013年第3期12卷 502-508页

作者： GE Ya-ming NING Hong-mei GU Xin-li YIN Mei YANG Xue-feng QI Yong-hua WANG Jun-dong College of Animal Science Henan Institute of Science and Technology Shanxi Key Laboratory of Ecological Animal Science and Environmental Medicine Shanxi Agricultural University College of Animal Science and Technology Shihezi University

Thirty-two Wistar rats were divided randomly into four groups of eight with six females and two males in each group. The rats were exposed to high fluoride drinking water （45 mg F-L^-1 from 100 mg NaF L-1）, low dietary iodine （0.0855 mg kg-1）, or both together in order to assess the effects of these three regimens on the thyroid function of the offspring rats. After the animal model was established, the offspring rats were bred and 10-, 20-, 30-, 60-, and 90-d-old rats were used for the experiment. The treatments for the offspring rats were the same as those of their parents. In comparison with control rats, the relative thyroid glands were changed by three regimens, but the mean values of thyroid weight in the experimental groups saw no marked difference. Serum TT3 levels were increased in all stages in the low iodine （LI） group. In the high fluoride （HiF） group, increase in TT3 levels was observed except in 20-d-old rats. Decrease in TT3 at 20- and 90-d and increase in TT3 at 30- and 60-d were found in HiF＋LI group. Serum TT4 levels first saw an increase, and then dropped in the LI and HiF＋LI group. However, an increase in TT4 was found in the HiF group. The levels of TSH in serum rocketed at d 20, and then dropped in the next stages in experimental groups. The results suggested that thyroid disorder could be induced by high flroride in drinking water, low iodine diet, or both of them. Exposure time to fluoride or low iodine diet was one of the important factors that fluoride can induce the development of thyroid dyfunction.

关键词： high fluoride iodine deficiency offspring rats thyroid function

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thyroid function in Pregnant Women from a West-African Population

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Open Journal of Molecular and Integrative Physiology 2018年第1期8卷 1-11页

作者： Bonaventure Awede Mariane SHounnou Christiane Tshabu-Aguemon Grace Adehan Francois Djrolo Marcellin Amoussou-Guenou Anatole Laleye Unite de Physiologie Faculte des Sciences de la SanteUniversite d’Abomey-CalaviCotonouBenin Unite de Gynecologie et d’Obstetrique Faculte des Sciences de la SanteUniversite d’Abomey-CalaviCotonouBenin Unite de Biophysique et de Medecine Nucleaire Facultédes Sciences de la SanteUniversite d’Abomey-CalaviCotonouBenin Unite d’Endocrinologie et de Nutrition Faculte des Sciences de la SanteUniversite d’Abomey-CalaviCotonouBenin Unite de Biologie Humaine Faculte des Sciences de la SanteUniversite d’Abomey-CalaviCotonouBenin

thyroid dysfunction is frequent in pregnant women and is often associated with an increased risk of adverse maternal and fetal outcome. In the present work, thyroid function of pregnant women from Benin republic was studied. Two hundred forty (240) pregnant women, without thyroid disease history, have been included in the study. A blood sample was drawn for measurement of TSH, free T3 and free T4 serum levels. From the first to the third trimester, plasma levels of free T3 and free T4 decreased when plasma levels of TSH increased. Using recommendations of the 2011 American thyroid Association (ATA) guidelines, thyroid dysfunction was observed in 24.17% of subjects. Hypothyroidism was present in 22.50% of subjects with 19.17% of subclinical hypothyroidism, 0.83% of overt hypothyroidism and 2.50% of hypothyroxinemia and hyperthyroidism was observed in 1.67% of subjects. An increase from 15.52% to 28.07% was observed in the frequency of hypothyroidism from the first to the third trimester of pregnancy. When an upper cut-off value of 4 mU/L was used for TSH, as recommended in the 2017 ATA guidelines, prevalence of thyroid disorders was 14.58% with 12.91% of hypothyroidism but no hypothyroidism was observed in women in the first trimester of pregnancy. A rise in hypothyroidism frequency was observed when pregnant women age increased. Hypothyroidism was very common in pregnant women in Benin. To allow accurate assessment of thyroid status in pregnant women in Benin, pregnancy specific range for plasma level of TSH and thyroid hormones should be established.

关键词： Pregnancy thyroid function Hypothyroidism

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Changing pattern of thyroid and adrenal function in postmenopausal women after hormone replacement therapy

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生殖医学杂志 2005年第B10期14卷 43-46页

作者：吕淑兰余珊珊曹缵孙 Research Laboratory of Reproductive Endocrinology the First Hospital of XJTUXi'an 710061 China

Objective:To investigate the changing pattern of thyroid and adrenal function in postmenopa-usal women;and the relationship between hormone replacement therapy(HRT)and thyroid andadrenal function.Methods:The levels of tT_3,tT_4,fT_3,fT4,TSH and cortisol were measured in 60 postmeno-pausal women(30 cases in HRT group;30 cases in control group)before and 12 months afterHRT.Results:The serum levels of tT_3,tT_4,fT_3,fT_4,TSH and cortisol had no significant differ-ence before and 12 months after HRT in postmenopausal women.The values of them were all innormal ranges.Conclusion:Changing pattern of thyroid and adrenal function was not as significant as that ofgonads in postmenopausal women and the impact of HRT on it was not so significantly evident.

关键词： HRT Postmenopause thyroid function Adrenal cortisol

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Study on the relationship of iodine nutritional status with thyroid function and autoantibodies in pregnant women in Baotou

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Discussion of Clinical Cases 2020年第1期7卷 3-7页

作者： Yuanyuan Fan Yalu Wang Chenhui Li Ziling Li Department of Endocrinology Baogang HospitalBaotouInner MongoliaChina The Second Military Medical University ShanghaiChina

Objective:To investigate the relationship of iodine nutritional status with thyroid function in pregnant women in Baotou,and provide a scientific basis for the guide of reasonable iodine supplementation.Methods:By use of As-Ce catalysis spectrophotometry,the urinary iodine concentration was determined in 90 women during different periods of pregnancy admitted to Baogang Hospital of Inner Mongolia from January 2017 to December 2017.The determination of thyroid function and the autoantibody level was carried out by electro-chemiluminescence immunoassay(ECLIA).Results:In the early trimester of pregnancy,pregnant women with iodine deficiency,iodine sufficiency and iodine excess accounted for 36.67%,40.00%and 23.33%respectively;in the middle trimester of pregnancy,they accounted for 66.67%,26.67%and 6.66%respectively;they made up 40.00%,40.00%and 20.00%respectively in the late trimester of pregnancy.The rate of iodine deficiency in women in the middle trimester of pregnancy was significantly higher than that in women in the early and the late trimesters of pregnancy respectively,and the difference was statistically significant(pthyroid peroxidase antibody.Moreover,it had no relationship with the positivity of thyroglobulin antibody.No matter in the pregnant women with iodine deficiency or with iodine excess,the abnormality rate of thyroid function and autoantibodies was significantly higher than that in the pregnant women with iodine sufficiency.The difference was statistically significant(pthyroid peroxidase antibody.Pregnant women with iodine deficiency and iodine excess show a higher abnormality rate of thyroid function and autoantibodies.It is recommended t

关键词： Iodine nutritional status Pregnancy Urinary iodine thyroid function

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Effect of Occupational Extremely Low-Frequency Electromagnetic Field Exposure on the thyroid Gland of Workers:A Prospective Study

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Current Medical Science 2022年第4期42卷 817-823页

作者： Yuan-yuan FANG Qian TU Yu-ting ZHANG Jian LIU Hui-guo LIU Zhi-hua ZHAO Hua WU Tie-jun YIN Department of Respiratory and Critical Care Medicine The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014China Department of Geriatric Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Respiratory and Critical Care Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Naval University of Engineering Wuhan 430030China Department of Orthopedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:The aim of this study was to investigate the biological effects of occupational extremely low-frequency electromagnetic field(ELF-EMF)exposure on the thyroid gland.Methods:We conducted a prospective analysis of 85 workers(exposure group)exposed to an ELF-EMF(100μT,10-100 Hz)produced by the electromagnetic aircraft launch system and followed up on thyroid function indices,immunological indices,and color Doppler images for 3 years.Additionally,116 healthy volunteers were randomly selected as controls(control group),the thyroid function of whom was compared to the exposure group.Results:No significant difference was observed in thyroid function between the exposure and control groups.During the follow-up of the exposure group,the serum free triiodothyronine(FT3)level was found to slowly decrease and free thyroxine(FT4)level slowly increase with increasing exposure time.However,no significant difference was found in thyroid-stimulating hormone(TSH)over the three years,and no significant difference was observed in the FT3,FT4 and TSH levels between different exposure subgroups.Furthermore,no significant changes were observed in thyroid autoantibody levels and ultrasound images between subgroups or over time.Conclusion:Long-term exposure to ELF-EMF may promote thyroid secretion of T4 and inhibit deiodination of T4 to T3.ELF-EMF has no significant effect on thyroid immune function and morphology.

关键词： extremely low-frequency electromagnetic field thyroid function thyroid autoantibody thyroid ultrasound thyroid nodule

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Occupational Radiation Exposure and Changes in thyroid Hormones in a Cohort of Chinese Medical Radiation Workers

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Biomedical and Environmental Sciences 2021年第4期34卷 282-289页

作者： GUO Qi Shan RUAN Ping HUANG Wei Xu HUANG Dai Zheng QIU Jia Chu School of Public Health Guangdong Pharmaceutical UniversityGuangzhou 510310GuangdongChina Guangdong Province Engineering&Technology Research Center for Medical 3D Printer and Personalized Medicine Guangzhou 510006GuangdongChina Department of Biomedical Engineering Guangdong Pharmaceutical UniversityGuangzhou 510006GuangdongChina Guangdong Prevention and Treatment Center for Occupational Disease Guangzhou 510300GuangdongChina Department of Biomedical Engineering Guangxi Medical UniversityNanning 530021GuangxiChina

Objective This study aimed to evaluate the association between occupational radiation exposure and changes in thyroid hormone levels among medical radiation workers.Methods This retrospective cohort study included 2,946 radiation workers from 20 Guangzhou hospitals.Data on general characteristics,participant radiation dosimetry,and thyroid function test results[thyroid-stimulating hormone(TSH),triiodothyronine(T3),and thyroid hormone(T4)]were extracted from dosimetry and medical records.The generalized estimating equation was used to evaluate the trend of changes in thyroid hormone levels over time and was adjusted for age,gender,and occupation.Results The average annual effective dose was very low and showed a general downward trend.During the follow-up period,changes in T3 and T4 levels among radiation workers were-0.015[95% confidence interval(CI)-0.018 to-0.012]nmol/L per year and-2.294(95%CI-2.426 to-2.162)nmol/L per year,respectively.thyroid hormone levels were significantly different between males and females.T3 levels in the group of upper quartile of dose were significantly higher than in the lower quartile group(P=0.006).No significant decreased trend in thyroid hormone levels was observed with increasing average effective doses.Conclusion thyroid hormone secretion might be affected even in low-dose radiation exposure environments.

关键词： Occupational radiation thyroid function Cohort

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Relationship between Serum TSH Level with Obesity and NAFLD in Euthyroid Subjects

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2012年第1期32卷 47-52页

作者：张皎月孙晖陈璐璐郑涓胡祥王素星陈婷 Department of Endocrinology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology

To explore the relationship between serum thyroid stimulating hormone (TSH) level and obesity and nonalcoholic fatty liver disease (NAFLD) in euthyroid subjects,1322 subjects were sub-jected to a questionnaire survey and physical examination.Fasting blood samples were collected to test serum TSH,plasma glucose and lipids.Fatty liver was diagnosed by type B ultrasonography.The rela-tionship between serum TSH level and body mass index (BMI),percentage of body fat and NAFLD was analyzed.The results showed that serum TSH level was significantly higher in females than in males at the same group,and it was significantly higher in overweight group than in control group.Levels of body weight,BMI,waist circumference and percentage of body fat were increased in TSH >2.5 group compared to TSH ≤2.5 group in women.However,plasma lipids showed no significant differences.In males all the parameters showed no significant differences between two groups.Serum TSH was sig-nificantly correlated with body weight,BMI,waist circumference and percentage of body fat after ad-justment for age in females.Multiple linear regression analysis revealed that percentage of body fat and BMI contributed significantly to the variance of TSH.Serum TSH level was significantly higher in non-alcoholic fatty liver group than in normal group in females.Multiple logistic regression analysis showed that TSH level was not the independent risk factor of NAFLD.Taken together the data suggest that se-rum TSH in normal range is significantly correlated with BMI and percentage of body fat in females.And the change of TSH level would not influence the prevalence of NAFLD.

关键词： thyroid stimulating hormone obesity lipid thyroid function nonalcoholic fatty liver dis-ease

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Iodine Concentration of Iodized Salts Consumed in Harper

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Open Journal of Applied Sciences 2022年第9期12卷 1495-1504页

作者： Richard Tamba Simbo Fayia Francis Nyuma Maria Fe Rebecca D. Gueta Department of Science and Mathematics College of Arts and Sciences William V.S Tubman University Maryland County Libe-ria

This study determined concentrations of iodine, consistent with WHO iodine fortification standards, in commercial edible salts mostly consumed in Harper. The following hypothesis was put forward in the research study;H1: the iodine content of the two brands of iodized salts is different from the WHO iodine fortification levels;H0: the iodine content of the two brands of iodized salts is not different from the WHO iodine fortification levels. The hypothesis was tested in MS Excel 2010 and 2016 via the T-Test function giving p-value = 0.1476 and p-value = 0.0395 indicative of no significant difference in the iodine concentration of the salts compared with the lower limit of WHO standard 20 mg·Kg-1 and huge contrast in the iodine concentration of the salts compared with the upper limit of WHO standard 40 mg·Kg-1 respectively. The UV spectrophotometric method was used to analyze and measure the iodine concentration in the twelve (12) samples of two different brands bought from grocery stores in Harper city. Results indicated that all samples of the two (2) brands of iodized salts contained iodine of no significant difference relative to the lower limit of WHO standard but far below the upper limit of the WHO standard. The study therefore recommends monitoring of commercial iodized salts by appropriate authorities in Harper to ascertain the WHO iodization fortification standards before reaching consumers.

关键词： Harper Iodized Salt Potassium Iodate Potassium Iodide Spectrophotomet-ric thyroid function

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Low serum iodine levels in adults increase the risk of iodine deficiency and clinical hypothyroidism

Low serum iodine levels in adults increase the risk of iodin...

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中国营养学会第十五届全国营养科学大会

作者： Tingting Xu Wanqi Zhang Long Tan wenxing Guo Zhiyuan Ren Hongyan Wei Ying Yang Department of Nutrition and Food Hygiene School of Public Health Tianjin Medical University Tianjin Key Laboratory of Environment Nutrition and Public Health Center for International Collaborative Research on Environment Nutrition and Public Health Department of Endocrinology and Metabolism Tianjin Medical University General Hospital Tianjin Medical University General Hospital

Serum iodine is a new index that can be used to judge the iodine nutrition status of patients. The relationship between low serum iodine and thyroid function in adults is not well understood, needs to be further clarified. In the present study, we aimed to explore the relationship between total serum and urinary iodine and thyroid function in the adult population in Tianjin non-high water iodine area. Methods A total of 1320 participants were enrolled in a cross-sectional survey. Basic demographic information was collected simultaneously, in addition to blood and spot urine samples, to determine serological indices and iodine nutritional status. Results The median(IQR) serum total iodine(StI) level was 70.5μg/L(59.6-83.6μg/L) and the 95% CI for StI was 44.3-106.5μg/L. When TSH > 5 mIU/L, StI concentration tended to decrease with increasing TSH levels. Compared to those with 59.6μg/L ≤ StI thyroidism(OR = 16.4, 95%CI: 3.72-72.2);StI ≤ 59.6μg/L had a higher risk of UIC thyroid stimulating hormone levels. Serum iodine is more sensitive than urine iodine in the diagnosis of thyroid dysfunction. In addition, low serum total iodine concentration was an indicator for an increased risk of iodine deficiency and hypothyroidism.

关键词： Serum total Iodine thyroid function Clinical hypothyroidism Adult

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The Effects of Iodine Nutrition During Pregnancy on Their Infants' Neurodevelopment at 18-24 Months: A Prospective Cohort Study

The Effects of Iodine Nutrition During Pregnancy on Their In...

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中国营养学会第十五届全国营养科学大会

作者： Wen Wu wanqi zhang yanting chen wenxing guo ziyun pan kexin zhang Tianjin Medical University 天津市总医院天津市环境与健康重点实验室广东医科大学公共卫生学院

Mild iodine deficiency during pregnancy for growth and development of infants has inconsistent. This study evaluated the effects of maternal iodine nutrition during pregnancy on their infants neurodevelopment. Methods From 2016 to 2018, pregnant women were enrolled from Tanggu, Tianjin and Wuqiang, Hebei. Spot urinary iodine concentration(UIC) was determined, venous blood were to measure free triiodothyronine(FT3), free thyroxine(FT4), TSH, thyroid peroxidase antibody(TPOAb), thyroglobulin antibody(TgAb), total serum iodine(TSI) and non-protein bound serum iodine(nbSI). Neonatal heel-blood was collected to determine TSH. Fingertip blood TSH and spot UIC were obtained at 18-24 months, meanwhile neurodevelopment was assessed by GESELL developmental scale. Results A total of 469 infants aged 18-24 months finished the GESELL developmental scale. With maternal UIC≥250μg/L, the risk of development quotient(DQ) ≤85 in adaptive domain increased to 2.38 fold(95%CI: 1.06, 5.35). The personal-social DQ positively correlated to maternal UIC within 100-149μg/L(P=0.046). An increasing risk of fine motor delay was along with maternal TSH ≥2.5 mIU/L(P=0.009). FT4 negatively correlated with personal-social DQ, when lower than the 25 th percentile, negatively correlated to fine motor DQ(P<0.05). TSI higher than the 95 th percentile increased language delay risk to 3.06 fold(95%CI: 1.09, 8.58). When neonatal TSH higher than the 75 th percentile negatively correlated with language and personalsocial DQ, when lower than the 25 th percentile negatively correlated with personalsocial DQ(P<0.05). Conclusion Maternal UIC, TSH, FT4, TSI and neonatal TSH correlated with infants neurodevelopment. More attention should be focused on iodine nutrition of pregnant women, even in iodine sufficient areas.

关键词： Pregnancy Infants Urinary iodine concentration thyroid function Neurodevelopment

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