Thyroid Function in Pregnant Women from a West-African Population

作     者：Bonaventure Awede Mariane SHounnou Christiane Tshabu-Aguemon Grace Adehan Francois Djrolo Marcellin Amoussou-Guenou Anatole Laleye 

作者机构：Unite de PhysiologieFaculte des Sciences de la SanteUniversite d’Abomey-CalaviCotonouBenin Unite de Gynecologie et d’ObstetriqueFaculte des Sciences de la SanteUniversite d’Abomey-CalaviCotonouBenin Unite de Biophysique et de Medecine NucleaireFacultédes Sciences de la SanteUniversite d’Abomey-CalaviCotonouBenin Unite d’Endocrinologie et de NutritionFaculte des Sciences de la SanteUniversite d’Abomey-CalaviCotonouBenin Unite de Biologie HumaineFaculte des Sciences de la SanteUniversite d’Abomey-CalaviCotonouBenin 

出 版 物：《Open Journal of Molecular and Integrative Physiology》 (分子和综合生理学期刊（英文）)

年 卷 期：2018年第8卷第1期

页      面：1-11页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Pregnancy Thyroid Function Hypothyroidism 

摘      要：Thyroid dysfunction is frequent in pregnant women and is often associated with an increased risk of adverse maternal and fetal outcome. In the present work, thyroid function of pregnant women from Benin republic was studied. Two hundred forty (240) pregnant women, without thyroid disease history, have been included in the study. A blood sample was drawn for measurement of TSH, free T3 and free T4 serum levels. From the first to the third trimester, plasma levels of free T3 and free T4 decreased when plasma levels of TSH increased. Using recommendations of the 2011 American Thyroid Association (ATA) guidelines, thyroid dysfunction was observed in 24.17% of subjects. Hypothyroidism was present in 22.50% of subjects with 19.17% of subclinical hypothyroidism, 0.83% of overt hypothyroidism and 2.50% of hypothyroxinemia and hyperthyroidism was observed in 1.67% of subjects. An increase from 15.52% to 28.07% was observed in the frequency of hypothyroidism from the first to the third trimester of pregnancy. When an upper cut-off value of 4 mU/L was used for TSH, as recommended in the 2017 ATA guidelines, prevalence of thyroid disorders was 14.58% with 12.91% of hypothyroidism but no hypothyroidism was observed in women in the first trimester of pregnancy. A rise in hypothyroidism frequency was observed when pregnant women age increased. Hypothyroidism was very common in pregnant women in Benin. To allow accurate assessment of thyroid status in pregnant women in Benin, pregnancy specific range for plasma level of TSH and thyroid hormones should be established.