检索结果-南通市图书馆

In the Basis of Hashimoto’s thyroiditis, to Form Papillary thyroid carcinoma, Metastasized and Then to De-Differentiate into Poorly Differentiated squamous cell carcinoma

引用

Journal of Cancer Therapy 2021年第5期12卷 254-267页

作者： Xinle Ren Di Zhu Hen Wang Jilin Wang Biyun Lin Yongfang Ou Bing Huang Jian Huang The Center of Pathological Diagnosis and Research Affiliated Hospital Guangdong Medical University Zhanjiang China Department of Pathology Zhanjiang Central People’s Hospital Zhanjiang China

thyroid squamous cell carcinoma is very rare. At present, it is limited to case reports. Since the thyroid follicular epithelium is the non-squamous epithelium, how primary squamous cell carcinoma (SCC) of the thyroid occurs is still a controversial issue. Hashimoto’s thyroiditis (HT) is considered to be an independent risk factor for thyroid cancer, under the basis of HT, how tumor cells evolve and develop to papillary thyroid carcinoma (PTC), and particularly to de-differentiate into SCC is elusive. We report a 72-year-old female patient who developed multiple subtypes of PTC on a basis of HT, and finally to de-differentiate into SCC within the local foci of lymph node metastasis. We found that there was a variety of sub-types of PTC in this patient in the background of HT. SCC was found within local lymph node metastasis. Pathomorphology, immunohistochemistry, and molecular pathology have confirmed that the SCC was derived from PTC, and then developed into poorly differentiated SCC and/or anaplastic carcinoma. We also conducted a comprehensive literature review.

关键词： Papillary thyroid Cancer thyroid squamous cell carcinoma Pathomorphology Molecular Pathology Multidisciplinary

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The effects of cAMP/PKA singnal pathway and TSA on proliferation of thyroid cancer

The effects of cAMP/PKA singnal pathway and TSA on prolifera...

引用

第三届泛环渤海（七省二市）生物化学与分子生物学会——2012年学术交流会

作者： Xiao Jian-ying Gaoyue Liuchao Zhaosong Department of Biochemical and Molecular Biology Liaoning Medial University

Objective:To investigate the effects of cAMP/PKA singnal pathway and TSA on proliferation of thyroid cancer cell line ***:SW579 cells were treated using dbcAMP(0. 5,1.0,and 2.0 mmol/l),after 24h,48h,and 72h,PKA activity and proliferation of the treated cells were investigated by ELISA and MIT methods respectively;SW579 cells were treated by 1.0 mmol/L dbcAMP,50nmol/L TSA,or 1.0mmol/LdbcAMP and 50nmol/L TSA, after 48h,PKA and MPF activities of the treated cells were detected using ELISA;the mRNAs of CyclinD1,CDK4,and Rb by RT - polymerase chain reaction(PCR);the proteins of PKA, Cyclinl,CDK4 and the phosporylated RB,CDC25B - pS323,and cdc2pTyrl5 by Western ***;The PKA activity of dbcAMP - treated SW579 cells increases in a concentration - and time - dependent *** of cAMP/PKA pathway by dbcAMP arrest SW579 cells at Gl phase,reduces cells at S phase while G2 - phase cells remain unchanged or ***,Activation of cAMP/PKA pathway by dbcAMP inhibits MPF activity, downregulates CyclinD1 mRNA and protein,reduces phosphorylated Rb protein,and increase phosphorylated CDC25B and cdc2,while we have not deceted any effect on CDK4 after Activation of cAMP/PKA *** to Activation of cAMP/PKA pathway,TSA also arrest SWS79cells at G1 phase,reduces cells at S phase while G2 - phase cells remain unchanged or ***,TSA inhibits MPF activity downregulates CyclinD1 mRNA and protein,reduces phosphorylated Rb protein,and increase phosphorylated CDC25B and cdc2,while we have not deceted any effect on CDK4 after treating SW579using *** TSA activates PKA and upregulates PKA protein suggesting TSA inhibits SW579 cell growth through activation of PKA ***579 cells treated using TSA and dbcAMP are more strongly arrested at Gl phase than one treated only using dbcAMP or TSA,and cells at S and G2 are more strongly reduced than one treated only using dbcAMP or TSA demonstrating a strong synergistic ***

关键词： Trichostatin A thyroid squamous cell carcinoma dbc AMP PKA CDC25B MPF

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：