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植物研究 1984年第2期 87-102页

作者：刘炳仑中国科学院植物研究所北京

本文对我国8属22种3变种的瑞香科植物花粉形态进行了观察。本科花粉具散孔,花粉形态属于单类型。根据纹饰特点,本文将瑞香科花粉分为具瘤状纹饰和具网状一巴豆型图案两个类型。另外,还对巴豆型图案和本科在被子植物中的系统位置等问题... 详细信息

本文对我国8属22种3变种的瑞香科植物花粉形态进行了观察。本科花粉具散孔,花粉形态属于单类型。根据纹饰特点,本文将瑞香科花粉分为具瘤状纹饰和具网状一巴豆型图案两个类型。另外,还对巴豆型图案和本科在被子植物中的系统位置等问题进行了讨论。

关键词：孔间距厚度巴豆层厚内层逐水药 thymelaeaceae 近球形薄片瑞香科图版图案外壁花粉形态植物

A new biflavone glucoside from the roots of Stellera chamaejasme

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Chinese Journal of Natural Medicines 2015年第7期13卷 550-553页

作者： CHEN Wei LUO Xiao-Hua WANG Zhuo ZHANG Ying-Ying LIU Li-Ping WANG Hong-Bing School of Life Sciences and Technology Tongji University

The present study investigated the chemical constituents of the roots of Stellera chamaejasme(thymelaeaceae).One new biflavone glucoside(1),along with other thirteen known compounds(2–14),was isolated by repeated column chromatographic methods and their structures were elucidated on the basis of spectral *** cytotoxic activities of selected compounds were evaluated against four human cancer cell lines(A549,BEL-7402,HCT-116,and MDA-MB-231) by the SRB assay *** 9 showed remarkable cytotoxicity against BEL-7402 with IC50 value being 0.65 μg·mL-1; compounds 7,8,and 12 exhibited significant cytotoxic activity against A549 with IC50 values being 2.38,1.57,and 2.35 μg·m L-1,respectively.

关键词： Stellera chamaejasme thymelaeaceae Biflavone glucoside Cytotoxicity

A new coumarin glycoside from Daphne giraldii

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Chinese Chemical Letters 2007年第7期18卷 835-836页

作者： Juan Su a, Zhi Jun Wu c, Run Hui Liu a, Yun Heng Shen a, Chuan Zhang a, Hui Liang Li a, Wei Zhang a, Wei Dong Zhang a,b,* a Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China b School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200030, China c Department of Research & Development, Shanghai Center of Research & Development of New Drugs, Shanghai 201203, China Department of Phytochemistry School of Pharmacy Second Military Medical University Shanghai 200433 China Department of Research & Development Shanghai Center of Research & Development of New Drugs Shanghai 201203 China School of Pharmacy Shanghai Jiao Tong University Shanghai 200030 China

A new coumarin glycoside was isolated from the ethanol extract of the barks of stem of Daphne giraldii Nitsche. Its structure was defined as daphnetin 8-O-b-D-glucopyranosyl-(1→6)-b-D-glucopyranoside on the basis of ... 详细信息

关键词： Daphne giraldii thymelaeaceae Coumarin glycoside Daphnetin 8-O-b-D-glucopyranosyl-(1→6)-b-D-glucopyranoside

Sesquiterpenoids and 2-(2-Phenylethyl)chromone Derivatives from the Resinous Heartwood of Aquilaria sinensis

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Natural Products and Bioprospecting 2021年第5期11卷 545-555页

作者： Shu‑Ya Wei Dong‑Bao Hu Meng‑Yuan Xia Ji‑Feng Luo Hui Yan Jing‑Hua Yang Yun‑Song Wang Yue‑Hu Wang Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of EducationSchool of Chemical Science and TechnologySchool of PharmacyYunnan UniversityKunming 650091People’s Republic of China Key Laboratory of Economic Plants and Biotechnology Yunnan Key Laboratory for Wild Plant Resourcesand State Key Laboratory of Phytochemistry and Plant Resources in West ChinaChinese Academy of SciencesKunming 650201People’s Republic of China School of Chemical Biology and Environment Yuxi Normal UniversityYuxi 653100People’s Republic of China

One novel spirolactone,aquilarisinolide(1),three new sesquiterpenoids,(2R,4S,5R,7R)-2-hydroxyeremophila-9,11-dien-8-one(2),(1R,4S,5S,7R,11R)-13-hydroxyepidaphnauran-9-en-8-one(3),and(4R,5S,7R,8S,10S,13R)-8,13-dihydroxyrotunda-1,11-dien-3-one(4),together with 13 known compounds(5-17)were isolated from the resinous heartwood of Aquilaria sinensis(thymelaeaceae).The structures of the new compounds were elucidated based on the analysis of NMR and MS data and theoretical calculations their ECD *** isolated compounds were evaluated for their protective activities against PC12 cell injury induced by corticosterone(CORT)and 1-methyl-4-phenylpyridine ion(MPP+),as well as inhibitory activities against *** 4,5,6-dihydroxy-2-(2-phenylethyl)chromone(5),daphnauranol B(7),6-methoxy-2-[2-(3-methyoxyphenyl)ethyl]chromone(10),isoagarotetrol(14),and 1-hydroxy-1,5-diphenylpentan-3-one(16)showed significant protective effects on CORT-induced injury in PC12 cells at a concentration of 20μM(P<0.001).Isoagarotetrol(14)showed a significant protective effect on MPP+-induced injury in PC12 cells at a concentration of 20μM(P<0.001),while compound 4 showed a moderate activity(P<0.01).The BACE1-inhibitory activities of all tested compounds were very weak with less than 30%inhibition at a concentration of 20μM.

关键词： thymelaeaceae Aquilaria sinensis Sesquiterpenoids 2-(2-phenylethyl)chromones Neuroprotective

Five new 2-(2-phenylethyl)chromone derivatives and three new sesquiterpenoids from the heartwood of Aquilaria sinensis, an aromatic medicine in China

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Natural Products and Bioprospecting 2022年第1期12卷 12-25页

作者： Lu Zhang Ping Yi Hui Yan Xiao-Nian Li Meng-Yuan Xia Jun Yang Ji-Feng Luo Yue-Qiu He Yue-Hu Wang Key Laboratory of Economic Plants and Biotechnology Yunnan Key Laboratory for Wild Plant Resourcesand State Key Laboratory of Phytochemistry and Plant Resources in West ChinaKunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China Key Laboratory of Chemistry for Natural Products of Guizhou Province Chinese Academy of SciencesGuiyang 550014People’s Republic of China Faculty of Plant Protection Yunnan Agricultural UniversityKunming 650201People’s Republic of China

Five new 2-(2-phenylethyl)chromone derivatives,(5S,6R,7R,8S,7ʹR)-7ʹ-hydroxyagarotetrol(1),(5S,6R,7R,8S,7ʹS)-7ʹ-hydroxyagarotetrol(2),(6S,7S,8R)-2-[2-(4-methoxyphenyl)ethyl]-6,7,8-trihydroxy-5,6,7,8-tetrahydrochromone(3),(6S,7S,8R)-2-(2-phenylethyl)-6,7,8-trihydroxy-5,6,7,8-tetrahydrochromone(4),(5S,6R,7S,8R)-2-(2-phenylethyl)-5,6,7-trihydroxy-5,6,7,8-tetrahydro-8-[2-(2-phenylethyl)-7-methoxychromonyl-6-oxy]chromone(5),three new sesquiterpenoids,(4S,5S,7S,8S,10S,13R)-7,8,13-trihydroxyrotunda-1,11-dien-3-one(6),(4S,5S,7S,8S,10S,13S)-7,8,13-trihydroxyrotunda-1,11-dien-3-one(7),and(4R,5S,7S,8S,10S,13S)-7,8,13-trihydroxyrotunda-1,11-dien-3-one(8),along with 14 known compounds were isolated from the resinous heartwood of Aquilaria sinensis(thymelaeaceae).The chemical structures of these new compounds were elucidated by 1D and 2D NMR and MS data,single-crystal X-ray diffraction analysis,and electronic circular dichroism(ECD)*** neuroprotective activities of these isolates were evaluated using an in vitro model of rat adrenal pheochromocytoma(PC12)cell injury induced by *** concentrations from 5 to 40μM,compounds 4 and 6,agarotetrol(9),and 6-hydroxy-2-(2-phenylethyl)chromone(17)showed significant protective activities against corticosterone-induced PC12 cell injury(P<0.001).

关键词： thymelaeaceae Aquilaria sinensis Sesquiterpenoids 2-(2-Phenylethyl)chromones Neuroprotective

Bioassay-guided isolation of cytotoxic constituents from the flowers of Aquilaria sinensis

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Natural Products and Bioprospecting 2022年第1期12卷 128-136页

作者： Jun Yang Dong-Bao Hu Meng-Yuan Xia Ji-Feng Luo Xing-Yu Li Yue-Hu Wang Key Laboratory of Economic Plants and Biotechnology and Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China School of Chemical Biology and Environment Yuxi Normal UniversityYuxi 653100People’s Republic of China College of Science Yunnan Agricultural UniversityKunming 650201People’s Republic of China

Bioassay-guided fractionation of the EtOH extract from the flowers of Aquilaria sinensis(Lour.)Spreng.(Thyme-laeaceae)led to the isolation of a new cucurbitane-type triterpenoid,aquilarolide A(1),along with five known compounds(2-6).The structure of 1 was elucidated by extensive 1D and 2D nuclear magnetic resonance(NMR)experiments and mass spectrometry(MS)data and theoretical calculations of its electronic circular dichroism(ECD)*** A,cucurbitacin E(3),cucurbitacin B(4),and 7-hydroxy-6-methoxy-2-[2-(4-methoxyphenyl)ethyl]-4H-1-benzopyran-4-one(6)showed significant cytotoxicity against human lung adenocarcinoma SPC-A-1,human lung squamous cell carcinoma NCI-H520,human lung adenocarcinoma A549,and paclitaxel-resistant A549(A549/Taxol)cell *** four active compounds,with IC_(50) values ranging from 0.002 to 0.91μM,had better inhibitory activities against A549/Taxol cells than paclitaxel(IC_(50)=1.80μM).Among them,cucurbitacin E(IC_(50)=0.002μM)is the most *** studies are needed to evaluate their in vivo antitumor activities and to clarify their mechanisms.

关键词： thymelaeaceae Aquilaria sinensis Paclitaxel-resistant lung cancer cells Cucurbitane-type triterpenoids

Natural products against HIV latency

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Acupuncture and Herbal Medicine 2021年第1期1卷 10-21页

作者： Kouharu Otsuki Mi Zhang Wei Li Faculty of Pharmaceutical Sciences Toho UniversityMiyama 2-2-1FunabashiChibaJapan

Antiretroviral therapy has achieved great success in suppressing human immunodeficiency virus(HIV)replication and transforming HIV infection from a fatal disease to a manageable chronic ***,the latent HIV reservoir persists in the body of HIVinfected individuals and is prone to ***,the development of new treatment methods aimed at a complete cure for HIV is *** leading strategy for HIV eradication is based on eliminating and preventing the reactivation of latent reservoirs through an approach known as“shock and kill.”This strategy involves the use of latency-reversing agents(LRAs)to activate the HIV provirus in latent viral reservoir *** LRAs can be obtained from natural resources,including plants and marine *** this review,we provide an overview of natural products used to eliminate HIV latency.

关键词： Diterpenoid Human immunodeficiency virus Human immunodeficiency virus latency Shock and kill thymelaeaceae

Chemical constituents from Aquilaria sinensis(Lour.) Gilg

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Journal of Chinese Pharmaceutical Sciences 2012年第1期21卷 88-92页

作者： Dong Chen Yue-Lin Song Chun-Xiao Nie Xu Ma Peng-Fei Tu State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China Patent Examination Cooperation Center of State Intellectual Property Office Beijing 100083China

To investigate the chemical constituents of the stems ofAquilaria sinensis （Lour.） Gilg, the separation and purification were performed by solvent extraction, repeated chromatography on silica gel, Sephadex LH-20 and prep-HPLC. The structures were determined by spectrum analysis. Thirteen known compounds were isolated and their structures were identified as justicidin A （1）, justidin F （2）, ciwujiatone （3）, （＋） syringaresinol （4）, syringaresinol-4,4＇-di-O-13-D-glucopyranoside （5）, syringaresinol-4＂O-β-D- glucopyranoside （6）, curuilignan D （7）, syringin （8）, koaburaside （9）, 3,4,5-trimethoxyphenyl-l-O-β-D-glucopyranoside （10）, 3,4,5-trimethoxyphenyl-l-O-13-D-apiofuranosyl-（1 ＂→6＇） glucopyranoside （11）, 7-ketositosterol （12）, 7-oxo-5,6-dihydrostigmasterol （13）. All the compounds described above were isolated from genus Aquilaria for the first time.

关键词： Aquilaria sinensis thymelaeaceae Chemical constituents Lignans Phenolicglycosides

Advance in Studies on Chemical Constituents, Pharmacology and Quality Control of Aquilaria sinensis

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Digital Chinese Medicine 2018年第4期1卷 316-330页

作者： Han-Wen YUAN Jian-Ping ZHAO Yong-Bei LIU Yi-Xing QIU Qing-Ling XIE Ming-Jiao LI Ikhlas A.KHAN Wei WANG National Center for Natural Products Research Research Institute of Pharmaceutical SciencesUniversity of MississippiMississippi 38677United States TCM and Ethnomedicine Innovation&Development International Laboratory Innovative Drug Research InstituteSchool of PharmacyHunan University of Chinese MedicineChangshaHunan 410208Ch

Aquilaria sinensis(thymelaeaceae)is widely cultivated in southern China for its significant medicinal *** resinous wood,the most used part of the plant as traditional Chinese medicine(TCM),locally called“Chen Xiang(沉香)”or Chinese agarwood,has been traditionally used for the treatment of circulatory disorders,abdominal pain,vomiting,and *** date,over 249 compounds have been isolated and identified from this plant.A range of bioactivities,including α-glucosidase inhibitory effects,anti-inflammatory,cytotoxicity,neuroprotective,anti-neuroinflammatory,antimicrobial and acetylcholinesterase inhibitory effects,along with some of the pharmacological mechanisms have been reported for the pure compounds or extracts of Aquilaria *** the purpose of quality control and clinical safety of drug usage,modern analytical instruments and chemical analysis methods have been applied for analyses of Aquilaria *** order to comprehensively understand the medicinal application and to fully utilize the plant,a literature search on the herb based on databases including SciFinder,Web of Science,Pubmed,Google Scholar and others was performed and the information regarding to the phytochemistry investigations,pharmacological studies and quality control was summarized in this paper.

关键词： Aquilaria sinensis thymelaeaceae Phytochemistry Pharmacological activity Quality control