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Chinese Journal of Chemistry 2019年第2期37卷 140-147页

作者： Zun Li Jia Zheng Chunsheng Li Wanqing Wu Huanfeng Jiang Key Laboratory of Functional Molecular Engineering of Guangdong Province School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhouGuangdong 510640China

Summary of main observation and conclusion An efficient Pd-catalyzed three-component coupling reaction of allyl carboxylates, norbornenes and diboronates is described, which allows efficient assembly of C(sp3)-C(sp3) and C(sp3)-B bonds in a single process. Moreover, this approach shows advantages of good chemo- and regioselectivity, as well as good substrates suitability.

关键词： Palladium-Catalyzed three-component Coupling Reaction Allyl Carboxylates

Copper-catalyzed three-component reaction of imidazo[1,2-a]pyridine with elemental sulfur and arylboronic acid to produce sulfenylimidazo[1,2-a]pyridines

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Chinese Chemical Letters 2018年第9期29卷 1363-1366页

作者： Genhua Xiao Hao Min Zhilei Zheng Guobo Deng Yun Liang National & Local Joint Engineering Laboratory for New Petro-chemical Materials and Fine Utilization of Resources Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research Ministry of Education Key Laboratory of the Assembly and Application of Organic Functional Molecules College of Chemistry and Chemical Engineering Hunan Normal University

In this work, an efficient copper-catalyzed three-component reaction for the synthesis of sulfenylimidazo [1,2-a]pyridines using elemental sulfur as the sulfenylating agents has been developed. The reaction could proceed smoothly with a high degree of functional group tolerance and provide the desired products in moderate to good yield.

关键词： Copper three-component Pyridine Sulfur Arylboronic acids

Cooperative NHC/Photoredox Catalysis:three-component Reaction of Aroyl Fluorides,Styrenes and Oxalates

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Chinese Journal of Chemistry 2024年第5期42卷 511-515页

作者： Zheng Lin Guanghui Lv Jianghong Liu Jiangyan Tang Binsong Mu Jian Chen Tianle Huang Zhongzhen Yang Yong Wu Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengduSichuan610041 China Department of Pharmacy Hubei Provincial Clinical Research Center for Umbilical Cord Blood Hematopoietic Stem CellsTaihe HospitalHubei University of MedicineShiyanHubei442000 China

Cooperative NHC/photoredox catalysis has emerged as an important research field in recent ***,this article describes the use of cesium salt derivatives of tert-alcohols as alkyl radical precursors in a three-component reaction with styrene and aromatic acyl fluorides to synthesizeα-arylalkyl aryl *** aroyl fluoride reacts with the NHC catalyst,leading to the formation of an acyl azolium *** acyl azolium ion can then be reduced by the photoredox catalyst,generating the corresponding ketyl radical *** C-radical generated from oxalate oxidation undergoes an addition reaction with the styrene derivative,followed by cross-coupling of the addition radical with the ketone radical,which is fragmented by NHC to give the target ketone.

关键词： three-component Photoredox NHC Aryl ketones Iridium Radical C—C coupling Amides

An efficient three-component domino synthesis of difluoromethyl-containing 1,4-dihydropyridines under solvent and catalyst free conditions

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Science China Chemistry 2010年第7期53卷 1509-1513页

作者： LI Hui YU JinLong CAO Song SHEN Li WU MingXi CHENG JianHang QIAN XuHong Shanghai Key Laboratory of Chemical Biology Center of Fluorine Chemical TechnologySchool of PharmacyEast China University of Science and TechnologyShanghai 200237China

The difluoromethyl-containing Hantzsch 1,4-dihydropyridines were synthesized in good yields by a one-pot cyclocondensation of ethyl difluoroacetoacetate (EDFAA),a variety of aromatic aldehydes and ammonium acetate under solvent and catalyst free *** comparison of reaction conditions and products was made among the different 1,3-carbonyl substrates (ethyl acetoacetate,ethyl difluoroacetoacetate and ethyl trifluoroacetoacetate) for the Hantzsch reaction.

关键词： three-component difluoromethyl 1,4-dihydropyridines ethyl difluoroacetoacetate

three-component Coupling Catalyzed by Phosphine: Preparation of α-Amino γ-Oxo Acid Derivatives

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International Journal of Organic Chemistry 2012年第2期2卷 111-116页

作者： Yohei Oe Takeshi Inoue Hiroaki Kishimoto Mitsuhiro Sasaki Tetsuo Ohta Isao Furukawa Department of Biomedical Information Faculty of Life and Medical Sciences Doshisha University Kyotanabe Kyoto 610-0394 Japan Department of Biomedical Information Faculty of Life and Medical Sciences Doshisha University Kyotanabe Kyoto 610-0394 Japan Department of Molecular Science and Technology Faculty of Engineering Doshisha University Kyotanabe Kyoto 610-0394 Japan Department of Molecular Science and Technology Faculty of Engineering Doshisha University Kyotanabe Kyoto 610-0394 Japan

The three-component coupling reaction of ethyl propiolate (1), phthalimide (2), and aldehyde (3) catalyzed by tripheny- lphosphine, was developed. A solution of an equivalent amount of 1 and 2 in benzaldehyde (3a) in the presence of 30 mol% of PPh3 was heated at 100?C for 48 h to give N-(1-ethoxycarbonyl-3-oxo-3-phenylpropyl)phthalimide (4a) in 83% yield. This reaction was thought to proceed via vinylphosphonium salt formed from the reaction of ethyl propiolate (1) with triphenylphosphine in situ.

关键词： three-component Coupling Phosphine 2-Amino-4-Oxocarboxylic Acid

Mechanistic insight into the high stereoselectivity of Co(Ⅲ)-catalyzed three-component C-H addition cascade

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Mechanistic insight into the high stereoselectivity of Co(Ⅲ...

Cu-Catalyzed three-component One-Pot Synthesis of Aryl Sulfide with Sulfur Powder under Aqueous Conditions

第十三届全国量子化学会议

作者： Xuexiang Ma Jianbiao Liu Fang Huang Chuanzhi Sun Dezhan Chen College of Chemistry Chemical Engineering and Materials ScienceCollaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of ShandongShandong Normal University

A three-component C(sp)-H bond addition across alkene and polarized π-bonds with high stereoselectivity was reported for which CpCo catalysis was shown to be much more effective than CpRh. The reaction demonstrated excellent group tolerance to afford products in good yields and high diastereoselectivity. Herein we carried out a detailed theoretical mechanistic study for the reation to elucidate the high stereoselectivity and great difference between CpRh and CpCo catalysis in both reactivity and stereoselectivity. The results show that the whole catalytic cycle, including C(sp)-H activation, insertion of alkene, isomerization, intermolecular aldol reaction and protodemetalation. The high stereoselectivity of the products depend on the cobalt enolate addition to the ald ehyde.

关键词： high stereoselectivity three-component C-H functionalization

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Cu-Catalyzed Three-Component One-Pot Synthesis of Aryl Sulfi...

Intermolecular dearomative oxidative coupling of indoles with ketones and sulfonylhydrazines catalyzed by I2:synthesis of[2,3]-fused indoline tetrahydropyridazines

中国化学会第十三届全国有机合成化学学术研讨会

作者： Xiao Fu-Hong Chen Shu-Qing Deng Guo-Jun Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education College of ChemistryXiangtan University

Aryl sulfides are ubiquitous structural motifs found in numerous pharmaceutically active compounds and medicinally important natural ***,a variety of methods for the C-S bond construction to synthesize aryl sulfides have been developed.A typical method is based on inorganic sulfur reagents,in which sulfur powder（S8）,which is abundant and smell-free in nature,has been extensively investigated for introducing sulfur atoms into organic molecules.[1] In recent years,the transition metal-catalyzed direct sulfenylation of C-H bond using inorganic sulfur as the sulfur source has attracted considerable interest,since this strategy provides a more atom-economic route to construct the C-S bond by omitting substrate ***,we and others have developed various approaches for C-H sulfuration using sulfur powder as sulfur source,[2] whereas most of the procedures described above were carried out in organic *** the perspective of green chemistry,water is a desirable reaction medium because of its inexpensive,nontoxic and *** our continuing efforts using water as an ideal solvent for the C-H sulfenylation,[3] herein,we disclose a novel and environmentally-friendly protocol for the synthesis of aryl sulfides via C-H bond functionalization of arenes with iodohydrocarbon and sulfur powder under aqueous conditions.

关键词： Cu-catalyzed sulfur powder three-component water

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Science China Chemistry 2016年第10期59卷 1311-1316页

作者： Feng Wei Liang Cheng Hongyan Huang Jiejie Liu Dong Wang Li Liu Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Molecular Recognition and Function Institute of Chemistry Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

A convergent construction of [2,3]-fused indoline tetrahydropyridazines via an I2/tert-butyl hydroperoxide(TBHP) catalyzed three-component dearomative oxidative coupling of indoles, hydrazines and acetophenone was established in moderate to good yields. This protocol provides a new approach for the synthesis of these biologically interesting fused indolines.

关键词： iodine indoline oxidative coupling hydrazones three-component tetrahydropyridazines

Cul-Catalyzed Multicomponent Synthesis of Aminoindolizines from Aldehydes, Amines, and Alkynes under Solvent-Free Conditions

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Chinese Journal of Chemistry 2013年第6期31卷 799-804页

作者： Changming Pan Jianping Zou Runsheng Zeng Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry Chemical Engineering and Mate- rials Science of Soochow University Suzhou Jiangsu 215123 China

A direct and efficient approach to 1-aminoindolizines through three-component one-pot reaction of heteroaryl aldehydes, secondary amines and terminal alkynes catalyzed by CuI under solvent-free conditions has been dev... 详细信息

关键词： three-component one-pot solvent-free CuI heteroaryl aldehydes

Palladium-catalyzed regioselective cascade reaction of carbon dioxide,amines and allenes for the synthesis of functionalized carbamates

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Science China Chemistry 2020年第3期63卷 331-335页

作者： Wenfang Xiong Ruixiang Cheng Bowen Wu Wanqing Wu Chaorong Qi Huanfeng Jiang Key Lab of Functional Molecular Engineering of Guangdong Province School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510640China State Key Lab of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640China

A palladium-catalyzed regioselective three-component cascade reaction of carbon dioxide,amines and allenes has been developed,providing an expedient and practical method for the construction of a range of functionalized carbamates containing dihydrobenzofuran or indole moiety in moderate to excellent *** broad substrate scope,good functional group tolerance and excellent chemo-and regioselectivity are the features of the transformation.

关键词： palladium carbon dioxide three-component reaction carbamates allenes