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therapeutic applications of collagenase(metalloproteases): A review

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Asian Pacific Journal of Tropical Biomedicine 2016年第11期6卷 975-981页

作者： Hamzeh Alipour Abbasali Raz Sedigheh Zakeri Navid Dinparast Djadid Malaria and Vector Research Group Biotechnology Research Center Pasteur Institute of Iran Department of Medical Entomology School of Health Research Center for Health Sciences Shiraz University of Medical Sciences

Non-invasive therapeutic methods have recently been used in medical sciences. Enzymes have shown high activity at very low concentrations in laboratories and pharmaceutical,enabling them to play crucial roles in different biological phenomena related to living organism, especially human medicine. Recently, using the therapeutic methods based on non-invasive approaches has been emphasized in medical society. Researchers have focused on producing medicines and tools reducing invasive procedures in *** are proteins which catalyze chemical processes and break the peptide bonds in collagen. Collagen may be generated more than the required amount or produced in unsuitable sites or may not degrade after a certain time. In such cases, using an injectable collagenase or its ointment can be helpful in collagen degradation. In both in vitro and in vivo tests, it has been revealed that collagenases have several therapeutic properties in wound healing, burns, nipple pain and some diseases including intervertebral disc herniation, keloid, cellulite, lipoma among others. This review describes the therapeutic application of collagenase in medical sciences and the process for its production using novel methods, paving the way for more effective and safe applications of collagenases.

关键词： Enzyme therapeutic application Collagenase Non-invasive Metalloproteinase

therapeutic applications of exosomes from adipose-derived stem cells in antifibrosis

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Chinese Journal of Plastic and Reconstructive Surgery 2021年第3期3卷 161-166页

作者： Liquan Wang Zhujun Li Yunzhu Li Jiuzuo Huang Nanze Yu Xiao Long Department of Plastic and Reconstructive Surgery State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College Hospital of Peking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China

Fibrosis is a condition in which connective tissue replaces normal parenchymal tissue,resulting in significant tissue *** can affect several organs and pose a serious threat to human health and *** stem cells(ASCs)have been suggested as promising candidates for antifibrotic *** secretion is one of the key processes in stem cell therapy due to its critical function in cellular ***-derived exosomes(ASC-exos)are used as tools for restoring and regenerating damaged tissue,and they are now thought to orchestrate antifibrosis-related *** this review,we summarize the recent findings and present an extensive view of the therapeutic applications of ASC-exos in fibrotic diseases.

关键词： Mesenchymal stem cell Adipose-derived stem cell Exosome Fibrosis Animal experiment therapeutic application

Base editors:development and applications in biomedicine

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Frontiers of Medicine 2023年第3期17卷 359-387页

作者： Yanhui Liang Fangbing Chen Kepin Wang Liangxue Lai China-New Zealand Joint Laboratory on Biomedicine and Health CAS Key Laboratory of Regenerative BiologyGuangdong Provincial Key Laboratory of Stem Cell and Regenerative MedicineCentre for Regenerative Medicine and HealthHong Kong Institute of Science and InnovationGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China Research Unit of Generation of Large Animal Disease Models Chinese Academy of Medical Sciences(2019RU015)Guangzhou 510530China Sanya Institute of Swine Resource Hainan Provincial Research Centre of Laboratory AnimalsSanya 572000China Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine Wuyi UniversityJiangmen 529020China

Base editor(BE)is a gene-editing tool developed by combining the CRISPR/Cas system with an individual deaminase,enabling precise single-base substitution in DNA or RNA without generating a DNA double-strand break(DSB)or requiring donor DNA templates in living *** editors offer more precise and secure genome-editing effects than other conventional artificial nuclease systems,such as CRISPR/Cas9,as the DSB induced by Cas9 will cause severe damage to the ***,base editors have important applications in the field of biomedicine,including gene function investigation,directed protein evolution,genetic lineage tracing,disease modeling,and gene *** the development of the two main base editors,cytosine base editors(CBEs)and adenine base editors(ABEs),scientists have developed more than 100 optimized base editors with improved editing efficiency,precision,specificity,targeting scope,and capacity to be delivered in vivo,greatly enhancing their application potential in ***,we review the recent development of base editors,summarize their applications in the biomedical field,and discuss future perspectives and challenges for therapeutic applications.

关键词： base editing CBE ABE ADAR DdCBE disease model therapeutic application

Advances in oral mesenchymal stem cell-derived extracellular vesicles in health and disease

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Genes & Diseases 2024年第1期11卷 346-357页

作者： Huanyu Luo Anahid Ahmadi Birjandi Feilong Ren Tianmeng Sun Paul T.Sharpe Hongchen Sun Zhengwen An Department of Oral Biology Jilin Provincial Key Laboratory of Tooth Development and Bone RemodelingSchool and Hospital of StomatologyJilin UniversityChangchunJilin 130021China Faculty of Dentistry Oral&Craniofacial SciencesCentre for Craniofacial and Regenerative BiologyKing's College LondonLondonSE19RTUK Department of Oral Pathology Jilin Provincial Key Laboratory of Tooth Development and Bone RemodelingSchool and Hospital of StomatologyJilin UniversityChangchunJilin 130021China

Extracellular vesicles(EVs)are nano-size vesicles secreted naturally by all cells into the extracellular space and have been recognized as important cell-cell mediators in multicel-lular *** contain nucleic acids,proteins,lipids,and other cellular components,regulating many basic biological processes and playing an important role in regenerative med-icine and *** can be traced to their cells of origin and exhibit a similar ***,EVs demonstrate low immunogenicity,good biocompatibility,and fewer side ef-fects,compared to their parent *** stem cells(MsCs)are one of the most important resource cells for EVs,with a great capacity for self-renewal and multipotent differ-entiation,and play an essential role in stem cell *** mechanism of MsC therapy was thought to be attributed to the differentiation of MsCs after targeted migration,as previously ***,emerging evidence shows the previously unknown role of MsC-derived para-crine factors in stem cell *** EVs derived from oral tissue MSCs(OMSC-EVs),show more advantages than those of all other MsCs in tissue repair and regeneration,due to their lower invasiveness and easier accessibility for sample ***,we systematically review the biogenesis and biological characteristics of OMSC-EVs,as well as the role of OMsC-EVs in intercellular ***,we discuss the potential therapeutic roles of OMSC-EVs in oral and systemic *** highlight the current challenges and future directions of OMSC-EVs to focus more attention on clinical *** aim to provide valuable insights for the explorative clinical application of OMSC-EVs.

关键词： Disease Extracellular vesicles Oral tissue MSC therapeutic application Tissue regeneration

Cancer recognition of artificial intelligence

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Artificial Intelligence in Cancer 2021年第1期2卷 1-6页

作者： Shihori Tanabe Division of Risk Assessment Center for Biological Safety and ResearchNational Institute of Health SciencesKawasaki 210-9501KanagawaJapan

The recognition mechanism of artificial intelligence(AI)is an interesting topic in understanding AI neural networks and their application in therapeutics.A number of multilayered neural networks can recognize cancer through deep *** would be interesting to think about whether human insights and AI attention are associated with each other or should be translated,which is one of the main points in this *** automatic detection of cancer with computeraided diagnosis is being applied in the clinic and should be improved with feature mapping in neural *** subtypes and stages of cancer,in terms of progression and metastasis,should be classified with AI for optimized *** determination of training and test data during learning and selection of appropriate AI models will be essential for therapeutic applications.

关键词： Artificial intelligence Cancer Network Recognition therapeutic application

Artificial intelligence in gastrointestinal diseases

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Artificial Intelligence in Gastroenterology 2021年第3期2卷 69-76页

作者： Shihori Tanabe Edward J Perkins Ryuichi Ono Hiroki Sasaki Division of Risk Assessment Center for Biological Safety and ResearchNational Institute of Health SciencesKawasaki 210-9501Japan Environmental Laboratory US Army Engineer Research and Development CenterVicksburgMS 3180United States Division of Cellular and Molecular Toxicology Center for Biological Safety and ResearchNational Institute of Health SciencesKawasaki 210-9501Japan Department of Clinical Genomics Fundamental Innovative Oncology CoreNational Cancer Center Research InstituteTokyo 104-0045Japan

Artificial intelligence(AI)applications are growing in *** is important to understand the current state of the AI applications prior to utilizing in disease research and *** this review,AI application in the diagnosis and treatment of gastrointestinal diseases are studied and *** most cases,AI studies had large amounts of data,including images,to learn to distinguish disease characteristics according to a human’s *** detailed pros and cons of utilizing AI approaches should be investigated in advance to ensure the safe application of AI in *** suggests that the collaborative usage of AI in both diagnosis and treatment of diseases will increase the precision and effectiveness of *** progress in genome technology such as genome editing provides a specific example where AI has revealed the diagnostic and therapeutic possibilities of RNA detection and targeting.

关键词： Artificial intelligence Gastrointestinal disease RNA therapeutic application Inflammatory diseases