Therapeutic applications of collagenase(metalloproteases): A review
Therapeutic applications of collagenase(metalloproteases): A review作者机构：Malaria and Vector Research Group Biotechnology Research Center Pasteur Institute of Iran Department of Medical Entomology School of Health Research Center for Health Sciences Shiraz University of Medical Sciences
出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)
年 卷 期：2016年第6卷第11期
页 面：975-981页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学]
基 金：Supported by Pasteur Institute of Iran and Iran National Science Foundation(Grant No.93011174)
主 题：Enzyme Therapeutic application Collagenase Non-invasive Metalloproteinase
摘 要：Non-invasive therapeutic methods have recently been used in medical sciences. Enzymes have shown high activity at very low concentrations in laboratories and pharmaceutical,enabling them to play crucial roles in different biological phenomena related to living organism, especially human medicine. Recently, using the therapeutic methods based on non-invasive approaches has been emphasized in medical society. Researchers have focused on producing medicines and tools reducing invasive procedures in *** are proteins which catalyze chemical processes and break the peptide bonds in collagen. Collagen may be generated more than the required amount or produced in unsuitable sites or may not degrade after a certain time. In such cases, using an injectable collagenase or its ointment can be helpful in collagen degradation. In both in vitro and in vivo tests, it has been revealed that collagenases have several therapeutic properties in wound healing, burns, nipple pain and some diseases including intervertebral disc herniation, keloid, cellulite, lipoma among others. This review describes the therapeutic application of collagenase in medical sciences and the process for its production using novel methods, paving the way for more effective and safe applications of collagenases.
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