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2019年浙江省医学会医学微生物与免疫学分会学术大会

作者： Yumei Ge Zhaozhao Yonglie Zhou Chunmei Ye Jinlin Liu Department of Clinical Laboratory Zhejiang Provincial People's HospitalHangzhou Medical College Zhejiang Chinese Medicine University Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province

Objective:The host immune response could be critical in the pathogenesis of Treponema pallidum(Tp) in latent syphilis *** aim of the present study was to examine changes of cellular homeostasis in T follicular regulatory T(tfr) cells in secondary syphilis patients and latent syphilis ***:Thirty healthy controls(HCs),24 secondary syphilis patients and 41 latent syphilis patients were *** percentages of total tfr,tfrl,tfr2,tfr17,and the PD-1,ICOS and CTLA-4 on the Treg cells,CXCR5-Treg cells and tfr cells in the peripheral blood were all determined by the flow ***:Comparing to the HCs and secondary syphilis patients,the percentage of total tfr cells and the tfr/Tfh ratio was significantly higher in latent syphilis patients,while the total Treg cells were not significant changed in the latent syphilis patients when compared to the secondary syphilis ***,no significant change was found on the tfrl,tfr2,tfr17 among the HCs and secondary syphilitic infection patients or the latent syphilis patients,except the tfr2 cells were increased in the latent syphilis ***,the ICOS and CTLA-4 percentages were all significantly increased on the tfr cells in latent syphilis patients when compared to the secondary syphilis ***:Increased tfr cells may play an important role in the immune evasion of Tp in latent syphilis patients.

关键词： tfr cells CTLA-4 Secondary syphilis Latent syphilis

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Highlights of the advances in basic immunology in 2011

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Cellular & Molecular Immunology 2012年第3期9卷 197-207页

作者： Juan Liu Shuxun Liu Xuetao Cao National Key Laboratory of Medical Immunology and Institute of Immunology Second Military Medical UniversityShanghaiChina National Key Laboratory of Medical Molecular Biology and Department of Immunology Chinese Academy of Medical SciencesBeijingChina

In this review, we summarize the major fundamental advances in immunological research reported in 2011. The highlights focus on the improved understanding of key questions in basic immunology, including the initiation and activation of innate responses as well as mechanisms for the development and function of various T-cell subsets. The research includes the identification of novel cytosolic RNA and DNA sensors as well as the identification of the novel regulators of the Toll-like receptor （TLR） and retinoic acid-inducible gene I （RIG-I）-Iike receptor （RLR） signaling pathway. Moreover, remarkable advances have been made in the developmental and functional properties of innate lymphoid cells （I LCs）. Helper T cells and regulatory T （Treg） cells play indispensable roles in orchestrating adaptive immunity. There have been exciting discoveries regarding the regulatory mechanisms of the development of distinct T-cell subsets, particularly Th17 cells and Treg cells. The emerging roles of microRNAs （miRNAs） in T cell immunity are discussed, as is the recent identification of a novel T-cell subset referred to as follicular regulatory T （tfr） cells.

关键词： ILC innate immunity Th17 cells tfr cells TLR

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