Circulating Tfr cells are increased in latent syphilis patients
作者单位：Department of Clinical LaboratoryZhejiang Provincial People's HospitalHangzhou Medical College Zhejiang Chinese Medicine University Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province
会议名称：《2019年浙江省医学会医学微生物与免疫学分会学术大会》
会议日期：2019年
学科分类：1002[医学-临床医学] 1010[医学-医学技术（可授医学、理学学位）] 100206[医学-皮肤病与性病学] 10[医学]
关 键 词：Tfr cells CTLA-4 Secondary syphilis Latent syphilis
摘 要：Objective:The host immune response could be critical in the pathogenesis of Treponema pallidum(Tp) in latent syphilis *** aim of the present study was to examine changes of cellular homeostasis in T follicular regulatory T(Tfr) cells in secondary syphilis patients and latent syphilis ***:Thirty healthy controls(HCs),24 secondary syphilis patients and 41 latent syphilis patients were *** percentages of total Tfr,Tfrl,Tfr2,Tfr17,and the PD-1,ICOS and CTLA-4 on the Treg cells,CXCR5-Treg cells and Tfr cells in the peripheral blood were all determined by the flow ***:Comparing to the HCs and secondary syphilis patients,the percentage of total Tfr cells and the Tfr/Tfh ratio was significantly higher in latent syphilis patients,while the total Treg cells were not significant changed in the latent syphilis patients when compared to the secondary syphilis ***,no significant change was found on the Tfrl,Tfr2,Tfr17 among the HCs and secondary syphilitic infection patients or the latent syphilis patients,except the Tfr2 cells were increased in the latent syphilis ***,the ICOS and CTLA-4 percentages were all significantly increased on the Tfr cells in latent syphilis patients when compared to the secondary syphilis ***:Increased Tfr cells may play an important role in the immune evasion of Tp in latent syphilis patients.