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Contrast-enhanced ultrasound as a valuable imaging modality for characterizing testicular lesions

Asian Journal of Andrology 2022年第2期24卷 201-206页

作者： Jie Yu Xin-Hui Jiang Lian-Fang Du Min Bai Zhao-Jun Li Qiu-Sheng Shi Qi Jiang Fan Li Department of Ultrasound Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201620China Department of Medical Ultrasound Shanghai Baoshan Hospital of Integrated Traditional Chinese and Western MedicineShanghai 201999China Department of Urology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China

Contrast-enhanced ultrasound(CEUS)is a new form of ultrasound(US)that can dynamically display microvessels in a highly sensitive *** purpose of this study was to investigate the efficacy of CEUS for characterizing testicular lesions in comparison with conventional ***-seven patients with testicular lesions were *** histopathology results revealed that 31 cases were neoplastic(11 cases of seminomas,8 nonseminomatous germ cell tumors,8 lymphomas,2 Leydig cell tumors,and 2 nonspecific tumors),and 16 cases were nonneoplastic(8 cases of infarctions,3 epidermoid cysts,and 5 inflammation).The indicators of shallow lobulated morphology and cystic-solid echogenicity on conventional US were suggestive of germ cell *** indicators on CEUS were found to be useful for characterizing testicular *** the neoplastic lesions showed hyperenhancement on ***,germ cell tumors presented with heterogeneous enhancement(73.7%,14/19),a twisted blood vessel pattern,rapid wash-in and wash-out,and peripheral rim hyperenhancement *** was characterized by nonbranching linear vessel patterns(87.5%,7/8),rapid wash-in and slow *** nonneoplastic lesions,infarction and epidermoid cysts showed no enhancement,and abscesses were observed with marginal irregular *** sensitivity,specificity,and accuracy of CEUS for differentiating between neoplastic and nonneoplastic lesions were 100%,93.8%,and 97.9%,respectively,and these values were higher than those for conventional US(90.3%,62.5%,and 80.9%,respectively).CEUS can sensitively reflect the microvascular perfusion in testicular lesions and offers high accuracy for characterizing them.

关键词： characterization contrast-enhanced ultrasound diagnosis testicular neoplasms ultrasound

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Primary testicular lymphoma:Clinical characteristics and oncological outcomes

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当代泌尿学（英文） 2023年第2期17卷 130-134页

作者： Alberto Artiles Medina Javier Lorca Álvaro Irene Carretero del Barrio Inés Laso García Mónica García Cosío Marina Mata Alcaraz Manuel Hevia Palacios Victoria Gómez Dos Santos Francisco Javier Burgos Revilla Department of Urology Hospital Universitario Ramón y CajalInstituto Ramón y Cajal de Investigación Sanitaria(IRYCIS)MadridSpain Department of Pathology Hospital Universitario Ramón y CajalMadridSpain

Background:Primary testicular lymphoma(PTL)is a rare testicular malignancy,despite being considered the most common testicular tumorin patients olderthan 60 *** testicularlymphoma represents only 1％-9％oftesticular *** studies have been published regarding its clinical features and *** study aimed to analyze the clinical characteristics and outcomes of PTL.Materials and methods:Orchiectomy specimens of 15 patients with PTL diagnosed during 2000-2020 at our institution were retro-spectively *** collected information on demographic data,clinical features,management aspects,and outcomes of PTL ***-Meier survival curves and Cox regression analyses were used to study survival.Results:The median patient age was 69 years(interquartile range,61-72 years).The most prevalent clinical presentation was testicular swelling(80％),and only 13.33％of the patients presented with systemic *** system involvement was detected in 6 patients(40％).Of the 15 patients,5(33.33％)had stage IE and 10(66.67％)had stage IVE *** large B-celllym-phoma was the most common histological *** patients(80％)received *** follow-up,4 patients(26.67％)*** recurrence ratein the contralateraltesticle was 13.33％.The median cancer-specific survivalwas 21.58 months(95％confidence interval,0-43.95 months).Univariate Cox regression analysis showed that central nervous system involvement and International Prognostic Index score were significantly associated with shorter cancer-specific survival.Conclusions:Primary testicularlymphoma has a high relapse rate and poor *** strategies typicallyinclude radical orchiectomy and systemic *** nervous system involvement and International Prognostic Index scores were associ-ated with lymphoma-specific survival.

关键词： Non-Hodgkin lymphoma Primary testicular lymphoma Prognosis testicular neoplasms Testis

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Influence of Combined Therapeutic Potential of Meso 2, 3-dimercaptosuccinic Acid and Calcium Disodium Edetate on Lead-induced testicular Alterations in Rats

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Biomedical and Environmental Sciences 1999年第4期12卷 285-291页

作者： GOVINDERJ·S·FLORA USHAARORA 等 IndustrialToxicologyResearchCentre PostBox80LucknowIndia DefenceResearchandDevelopmentEstablishment

The therapeutic efficacy of a combinaion of meso 2,3-dimeroaptosuccinic acid (DMSA) and calcium disodium EDTA in protecting testicular disorders in chronic lead intoxication was investigated. The results indicate that two five-days courses of the combined therapy produced a more effective recovery in the lead induced biochemical and histopahological disorders compared to conventional single 5 days therapy. No adverse effect of the chelators, when administered individually or in combination, was noticed in the testes of control (without lead exposure) animals.

关键词： Animals Chelating Agents Edetic Acid Lead Male Rats Succimer testicular neoplasms Testis

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Maternal cigarette smoking during pregnancy and reproductive health in children： a review of epidemiological studies

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Asian Journal of Andrology 2014年第1期16卷 39-49页

作者： Linn Berger Hfikonsen Andreas Ernst Cecilia Host Ramlau-Hansen Department of Public Health Section for Epidemiology Aarhus University Aarhus Denmark

Maternal cigarette smoking may affect the intrauterine hormonal environment during pregnancy and this early fetal exposure may have detrimental effects on the future trajectory of reproductive health. In this review, we discuss the epidemiological literature on the association between prenatal exposure to maternal cigarette smoking and several aspects of reproductive health. The literature points towards an increased risk of the urogenital malformation cryptorchidism, but a potential protective effect on the risk of hypospadias in sons following prenatal cigarette smoking exposure. Studies on sexual maturation find a tendency towards accelerated pubertal development in exposed boys and girls. In adult life, prenatally exposed men have impaired semen quality compared with unexposed individuals, but an influence on fecundability, that is, the biological ability to reproduce, is less evident. We found no evidence to support an association between prenatal cigarette smoking exposure and testicular cancer. Among adult daughters, research is sparse and inconsistent, but exposure to cigarette smoking in utero may decrease fecundability. In conclusion, prenatal exposure to cigarette smoking may cause some long-term adverse effects on the reproductive health.

关键词： fertility prenatal exposure puberty testicular neoplasms time-to-pregnancy

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Diffusion-weighted MR imaging of normal and abnorma scrotum： preliminary results

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Asian Journal of Andrology 2012年第4期14卷 649-654页

作者： Athina C Tsili Maria I Argyropoulou Dimitrios Giannakis Stavros Tsampalas Nikolaos Sofikitis Konstantinos Tsampoulas Department of Clinical Radiology University Hospital of Ioannina Ioannina 45500 Greece Department of Urology University Hospital of Ioannina Ioannina 45500 Greece

Magnetic resonance （MR） imaging of the scrotum represents an important supplemental diagnostic tool in the evaluation of scrotal diseases. Diffusion-weighted （DW） MR imaging is a developing technique, proved to improve tissue characterization. We evaluated the feasibility and diagnostic performance of DW MR imaging in the detection and characterization of scrotal lesions. We retrospectively evaluated 31 scrotal lesions （23 intratesticular and 8 extratesticular） in 26 men. All MR examinations were performed on a 1.5-T unit, using a pelvic-phased array coil. DW sequences were obtained using a single shot, multislice spin echo planar diffusion pulse sequence and a b factor of 0 and 900 s mm-2. The DW MR characteristics and the apparent diffusion coefficient （ADC） values of normal scrotal contents and scrotal diseases were evaluated. Comparison between the ADC values of normal scrotum, benign lesions and scrotal malignancies was performed. The accuracy of conventional sequences, DW images alone and DW imaging combined with conventional images in differentiating benign from malignant scmtal lesions was calculated. The ADC values of testicular malignancies were different from those of normal testis and benign intratesticular lesions, and the ADC values of benign extratesticular lesions from those of normal epididymis （P〈0.05）. The overall accuracy of conventional imaging, DW imaging alone and DW MR combined with conventional sequences in the characterization of intratesticular lesions was 91%, 87% and 100%, respectively. Our findings suggest that DW MR imaging and ADC values may provide valuable information in the diagnosis and characterization of scrotal diseases.

关键词： diagnosis epididymis male genital neoplasms scrotum testicular neoplasms testis

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Successful treatment of a high-risk nonseminomatous germ cell tumor using etoposide, methotrexate, actinomycin D, cyclophosphamide, and vincristine: A case report

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World Journal of Clinical Cases 2020年第21期8卷 5334-5340页

作者： Jina Yun Sang W Lee Sung H Lim Se H Kim Chan K Kim Seong K Park Department of Internal Medicine Division of Hematology-OncologySoonchunhyang University Bucheon HospitalSoonchunhyang University School of MedicineBucheon 14584South Korea Department of Urology and Internal Medicine Soonchunhyang University Bucheon HospitalSoonchunhyang University School of MedicineBucheon 14584South Korea

BACKGROUND Choriocarcinoma is an infrequent entity and the most aggressive subtype of germcell *** of early metastatic spread and rapid disease progression,choriocarcinoma patients display poor *** etoposide,methotrexate,actinomycin D,cyclophosphamide,and vincristine(EMA-CO)regimen is widely used to treat gestational trophoblastic tumors in females,its role in treating male choriocarcinoma is seldom *** SUMMARY A 32-year-old man was diagnosed with burned-out primary germ cell tumors(GCT)with retroperitoneum,liver and lung *** of the liver revealed pure *** patient received bleomycin,etoposide,and cisplatin *** two cycles of treatment,response evaluation revealed the mixed ***-CO regimen was used in the second-line *** eight cycles,the patient showed a potentially resectable state and thus,all residual masses were surgically *** patient was completely cured,and 10 years later,he is leading a healthy life without *** This paper is the first case of high-risk nonseminomatous GCT in a male patient to be successfully treated with the EMA-CO *** EMA-CO regimen can be used actively in patients with high-risk nonseminomatous GCT.

关键词： Antineoplastic combined chemotherapy protocols Choriocarcinoma testicular neoplasms Cyclophosphamide Methotrexate Case report

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Undescended epididymo-testicular metastasis from prostatic carcinoma

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Asian Journal of Andrology 2006年第2期8卷 251-252页

作者： Li-Ping Xie Jie Qin Xiang-Yi Zheng Zhao-Dian Chen Department of Urology First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China

Dear Sir, Metastasis of prostatic carcinoma to testis is un- common in the clinical situation, and the involvement of the epididymis is even rarer. Heidrich et al. [1] found only 80 cases of testicular involvement in prostate cancer in published reports. In 1993, Wiebe et al. [2] found only 14 previous cases of epididymal metastasis from prostatic carcinoma in published work. The simulta- neous involvement of testis and epididymis was reported by Suhler and Blanchard in 1980 [3]. To our knowledge, this was the first documented case of a prostatic carcinoma metastasizing to undescended testis and epididymis.

关键词： Adenocarcinoma Aged, 80 and over Cryptorchidism Humans Male Prostatic neoplasms testicular neoplasms

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Predictors of sperm recovery after cryopreservation n testicular cancer

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Asian Journal of Andrology 2016年第1期18卷 35-38页

作者： James M Hotaling Darshan P Patel Christopher Vendryes Natalya A Lopushnyan Angela P Presson Chong Zhang charles H Muller Thomas J Walsh Division of Urology Department of Surgery University of Utah Salt Lake City UT 84132 USA Department of Urology University of Illinois-Chicago Chicago IL 60612 USA Department of Urology University of Washington Seattle WA 98195 USA Division of Epidemiology Department of Internal Medicine University of Utah Salt Lake City UT 84132 USA

Our objective was to identify predictors of improved postthaw semen quality in men with testicular cancer banking sperm for fertility preservation. We reviewed 173 individual semen samples provided by 67 men with testicular germ cell tumor （TGCT） who cryopreserved sperm before gonadotoxic treatment between 1994 and 2010 at our tertiary university medical center. Our main outcomes measures were independent predictors for the greater postthaw total motile count （TMC） in men with TGCT. Men with NSGCT were more likely to be younger （P 〈 0.01） and had high cancer stage （Ⅱ or Ⅲ, P 〈 0.01） compared with men with seminoma. In our multiple regression model, NSGCT histology, use of density gradient purification, and fresh TMC 〉 median fresh TMC each had increased odds of a postthaw TMC greater than median postthaw TMC. Interestingly, age, advanced cancer stage （11 or III）, rapid freezing protocol, and motility enhancer did not show increased odds of improved postthaw TMC in our models. In conclusion, men with TGCT or poor fresh TMC should consider preserving additional vials （at least 15 vials） before oncologic treatment. Density gradient purification should be routinely used to optimize postthaw TMC in men with TGCT. Larger, randomized studies evaluating cancer stage and various cryopreservation techniques are needed to assist in counseling men with TGCT regarding fertility preservation and optimizing cryosurvival.

关键词： cryopreservation fertility preservation seminoma testicular neoplasms

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Robot-assisted retroperitoneal lymphadenectomy:The state of art

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Asian Journal of Urology 2021年第1期8卷 27-37页

作者： Gilberto J.Rodrigues Giuliano B.Guglielmetti Marcelo Orvieto Kulthe Ramesh Seetharam Bhat Vipul R.Patel Rafael F.Coelho Sao Paulo State Cancer Institute University of Sao Paulo School of MedicineSao PauloBrazil Clı´nica Alemana SantiagoChile Department of Urology AdventHealth Global Robotics InstituteCelebrationFLUnited States

Objective:To perform a narrative review about the role of robot-assisted retroperitoneal lymphadenectomy(R-RPLND)in the management of testicular ***:A PubMed search for all relevant publications regarding the R-RPLND series up until August 2019 was *** largest series were identified,and weighted means calculated for outcomes using the number of patients included in each study as the weighting ***:Fifty-six articles of R-RPLND were identified and eight series with more than 10 patients in each were *** weighted mean age was 31.12 years;primary and post chemotherapy R-RPLND were performed in 50.59%and 49.41%of *** clinical stage was I,II and III in 47.20%,39.57%and 13.23%of patients.A modified R-RPLND template was used in 78.02%of patients,while 21.98%underwent bilateral full *** weighted mean node yield,operative time and estimated blood loss were,respectively,22.15 nodes,277.35 min and 131.94 *** weighted mean length of hospital stay was 2 days and antegrade ejaculation was preserved in 92.12%of *** post-operative complications(Clavien III or IV)occurred in 5.34%.Positive pathological nodes were detected in 24.54%,while the recurrence free survival was 95.77%with a follow-up of 21.81 ***:R-RPLND has proven to be a reproducible and safe approach in experienced centers;short-term oncologic outcomes are similar to the open approach with less morbidity and shorter convalescence related to its minimal ***,longer follow-up and new trials comparing head-to-head both techniques are expected.

关键词： testicular neoplasms Lymphadenectomy Robotic surgical procedures

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【原创论文】德国东西部睾丸癌后发生第二原发癌的风险关注对侧睾丸癌

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Asian Journal of Andrology 2014年第2期16卷 285-289,I0010,I0011页

作者： Carsten Rusner Brigitte Streller Christa Stegmaier Pietro Trocchi Oliver Kuss Katherine A McGlynn Britton Traberts Andreas Stang Institute of Clinical Epidemiology Medical Faculty Martin-Luther-University of Halle-Wittenberg Halle (Saale) Common Cancer Registry of Berlin Berlin Saarland Cancer Registry Saarbrucken Institute of Medical Epidemiology Biostatistics and Informatics Medical Faculty Martin-Luther-University of Halle-Wittenberg Halle (Saale) Germany Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Bethesda MD Department of Epidemiology Scfloof of Public Heaftfl Boston University Boston MA USA.

testicular cancer survival rates improved dramatically after cisplatin-based therapy was introduced in the 1970s. However, chemotherapy and radiation therapy are potentially carcinogenic. The purpose of this study was to estimate the risk of developing second primary cancers including the risk associated with primary histologic type （seminoma and non-seminoma） among testicular cancer survivors in Germany. We identified 16 990 and 1401 cases of testicular cancer in population-based cancer registries of East Germany （1961-1989 and 1996-2008） and Saarland （a federal state in West Germany; 1970-2008）, respectively. We estimated the risk of a second primary cancer using standardized incidence ratios （SIRs） with 95% confidence intervals （95% Cls）. To determine trends, we plotted model-based estimated annual SIRs. In East Germany, a total of 301 second primary cancers of any location were observed between 1961 and 1989 （SIR： 1.9; 95% Ch 1.7-2.1）, and 159 cancers （any location） were observed between 1996 and 2008 （SIR： 1.7; 95% Ch 1.4-2.0）. The SIRs for contralateral testicular cancer were increased in the registries with a range from 6.0 in Saarland to 13.9 in East Germany. The SIR for seminoma, in particular, was higher in East Germany compared to the other registries. We observed constant trends in the model-based SIRs for contralateral testicular cancers. The majority of reported SIRs of other cancer sites including histology-specific risks showed low precisions of estimated effects, likely due to small sample sizes. testicular cancer patients are at increased risk especially for cancers of the contralateral testis and should receive intensive follow-ups.

关键词： cancer registry incidence neoplasms second primary testicular neoplasms

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