Maternal cigarette smoking during pregnancy and reproductive health in children： a review of epidemiological studies
Maternal cigarette smoking during pregnancy and reproductive health in children： a review of epidemiological studies作者机构：Department of Public Health Section for Epidemiology Aarhus University Aarhus Denmark
出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)
年 卷 期：2014年第16卷第1期
页 面：39-49页
核心收录：
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 0905[农学-畜牧学] 09[农学] 10[医学] 100404[医学-儿少卫生与妇幼保健学]
主 题：fertility prenatal exposure puberty testicular neoplasms time-to-pregnancy
摘 要：Maternal cigarette smoking may affect the intrauterine hormonal environment during pregnancy and this early fetal exposure may have detrimental effects on the future trajectory of reproductive health. In this review, we discuss the epidemiological literature on the association between prenatal exposure to maternal cigarette smoking and several aspects of reproductive health. The literature points towards an increased risk of the urogenital malformation cryptorchidism, but a potential protective effect on the risk of hypospadias in sons following prenatal cigarette smoking exposure. Studies on sexual maturation find a tendency towards accelerated pubertal development in exposed boys and girls. In adult life, prenatally exposed men have impaired semen quality compared with unexposed individuals, but an influence on fecundability, that is, the biological ability to reproduce, is less evident. We found no evidence to support an association between prenatal cigarette smoking exposure and testicular cancer. Among adult daughters, research is sparse and inconsistent, but exposure to cigarette smoking in utero may decrease fecundability. In conclusion, prenatal exposure to cigarette smoking may cause some long-term adverse effects on the reproductive health.
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