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tear inflammation related indexes after cataract surgery in elderly patients with type 2 diabetes mellitus

World Journal of Clinical Cases 2023年第2期11卷 385-393页

作者： Jun Lv Cheng-Jian Cao Wei Li Shuang-Le Li Jun Zheng Xiu-Li Yang Department of Optometry North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Zigong Academy of Medical Sciences Zigong First People’s HospitalZigong 643000Sichuan ProvinceChina FB Biologie Philipps-Universitaet MarburgMarburg 35043Germany Department of Ophthalmology Zigong First People’s HospitalZigong 643000Sichuan ProvinceChina

BACKGROUND Quantitative studies on the changes in inflammation-related content in tears,especially the effect of diabetes,are *** this study,we measured the preoperative and postoperative tear inflammatory mediator levels in cataract patients,focusing on the expression of inflammatory factors in postoperative cataracts in the diabetic,and investigated the effect of drugs on the control of postoperative *** To study the expression of inflammatory factors in elderly people with type 2 diabetes after cataract *** Patients with a mean age of 70.3±6.3 years were divided into group A(composed of elderly patients with cataracts and type 2 diabetes,n=20 eyes)and group B(patients with age-related cataract,n=20 eyes).Their tears were collected before each operation and on days 1 and 3,and weeks 1,2,3,and 4 ***(150μL)was dropped into the conjunctival sac of the surgical eye,followed by oculogyration in four *** fluid in the conjunctival sac was extracted using a sterile syringe and stored in Eppendorf tubes at-80°C until *** expression levels of matrix metalloproteinase-2(MMP-2),MMP-9,tissue inhibitor of metalloproteinase-1(TIMP-1),TIMP-2,interleukin-6(IL-6),and IL-20 in tear fluid were measured using enzyme-linked immunosorbent *** The postoperative expression levels of MMP-2,MMP-9,TIMP-2,IL-6,and IL-20 in group A were significantly higher than those in group B,whereas the concentration of TIMP-1 in group A remained lower than that in group *** levels of MMP-2 and IL-6 in both groups continuously increased until the peak in the first postoperative week,and then gradually decreased over the next three ***,MMP-2 declined to a lower level than that preoperatively at week 4,but IL-6 decreased to the same level as that *** level of MMP-9 peaked in the first two weeks postoperative and then returned to the same level as 1-day *** concentration of TIMP-1 pos

关键词： Type 2 diabetes mellitus Elderly patients Cataract surgery tear inflammation-related indicators Temporal changes Prognosis

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