Tear inflammation related indexes after cataract surgery in elderly patients with type 2 diabetes mellitus

作     者：Jun Lv Cheng-Jian Cao Wei Li Shuang-Le Li Jun Zheng Xiu-Li Yang 

作者机构：Department of OptometryNorth Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Zigong Academy of Medical SciencesZigong First People’s HospitalZigong 643000Sichuan ProvinceChina FB BiologiePhilipps-Universitaet MarburgMarburg 35043Germany Department of OphthalmologyZigong First People’s HospitalZigong 643000Sichuan ProvinceChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2023年第11卷第2期

页      面：385-393页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by Cataract Prevention and Control Appropriate Technology Base of Sichuan Provincial Health Commission(Regional Demonstration) No.2022JDXM012 

主　　题：Type 2 diabetes mellitus Elderly patients Cataract surgery Tear inflammation-related indicators Temporal changes Prognosis 

摘      要：BACKGROUND Quantitative studies on the changes in inflammation-related content in tears,especially the effect of diabetes,are *** this study,we measured the preoperative and postoperative tear inflammatory mediator levels in cataract patients,focusing on the expression of inflammatory factors in postoperative cataracts in the diabetic,and investigated the effect of drugs on the control of postoperative *** To study the expression of inflammatory factors in elderly people with type 2 diabetes after cataract *** Patients with a mean age of 70.3±6.3 years were divided into group A(composed of elderly patients with cataracts and type 2 diabetes,n=20 eyes)and group B(patients with age-related cataract,n=20 eyes).Their tears were collected before each operation and on days 1 and 3,and weeks 1,2,3,and 4 ***(150μL)was dropped into the conjunctival sac of the surgical eye,followed by oculogyration in four *** fluid in the conjunctival sac was extracted using a sterile syringe and stored in Eppendorf tubes at-80°C until *** expression levels of matrix metalloproteinase-2(MMP-2),MMP-9,tissue inhibitor of metalloproteinase-1(TIMP-1),TIMP-2,interleukin-6(IL-6),and IL-20 in tear fluid were measured using enzyme-linked immunosorbent *** The postoperative expression levels of MMP-2,MMP-9,TIMP-2,IL-6,and IL-20 in group A were significantly higher than those in group B,whereas the concentration of TIMP-1 in group A remained lower than that in group *** levels of MMP-2 and IL-6 in both groups continuously increased until the peak in the first postoperative week,and then gradually decreased over the next three ***,MMP-2 declined to a lower level than that preoperatively at week 4,but IL-6 decreased to the same level as that *** level of MMP-9 peaked in the first two weeks postoperative and then returned to the same level as 1-day *** concentration of TIMP-1 pos