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Changes in corneal nerve morphology and function in patients with dry eyes having type 2 diabetes

World Journal of Clinical Cases 2022年第10期10卷 3014-3026页

作者： Wei Fang Zhong-Xi Lin Hui-Qing Yang Lei Zhao Da-Chuan Liu Zhi-Qiang Pan Department of Ophthalmology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100005BeijingChina Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Endocrinology Xuanwu HospitalCapital Medical UniversityBeijing 100053China

BACKGROUND Dry eye syndrome(DES)is a common disease with various clinical *** had a significant association with *** reflex(BR)is also known as trigeminal nerve facial *** stimulation of corneal nerves is one of the origins of BR *** parasympathetic fibers sent out through the facial nerve are the outlet of tear *** can be used to assess the function of the corneal nerve closed-loop;however,whether the BR changes in these patients is *** To understand the morphology and function of the corneal nerve in patients with dry eyes having diabetes or *** This study enrolled 131 patients who visited the inpatient and outpatient services of ophthalmology and endocrinology departments between January 2019 to August 2020 with subjective symptoms of dry eyes and non-dry eye reasons,as well as volunteers such as *** patients were divided into four groups:DEwDM,with dry eyes having type 2 diabetes mellitus(T2DM);DMnDE,with T2DM not having dry eyes;DEnDM,with dry eyes not having diabetes;and nDMnDE,with neither dry eyes nor *** tear film break-up time,Schirmer I test,in vivo confocal microscopy,and BR were *** The DEwDM,DMnDE,DEnDM,and nDMnDE groups included 56,22,33,and 20 patients,*** and age were not statistically different among the four *** nerve fiber length(NFL)of patients in the DEwDM,DEnDM,and DMnDE groups reduced(P<0.001,P=0.014,and P=0.001,respectively).No significant difference in corneal nerve fiber density(NFD)(P=0.083)and corneal nerve branch density(NBD)(P=0.195)was found among the four *** R1 Latency of blink reflexes increased only in the DEwDM group(P=0.008,P=0.001,P<0.001,compared with the DMnDE,DEnDM,and nDMnDE groups,respectively).The NBD and R1 Latency were different between DEwDM and DEnDM groups in patients with moderate and severe dry *** The corneal nerve morphology changed in patients with dry eyes or diabetes,or

关键词： Blink reflex Corneal nerve Diabetes mellitus Dry eye tear secretion

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Efficacy observation of acupuncture for dry eye syndrome of lung-yin deficiency pattern

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Journal of Acupuncture and Tuina Science 2021年第1期19卷 72-77页

作者： Liu Jing-wen Zhao Yao-dong Zhu Ling Han Cong Gansu University of Chinese Medicine Lanzhou 730000China

Objective:To observe the clinical efficacy of combining two needling manipulations,Er Long Xi Zhu(two dragons playing with a pearl)and Guo Yan Re(heat produced to reach the eyes),in treating dry eye syndrome(DES)of lung-yin deficiency ***:Fifty-six eligible DES patients of lung-yin deficiency were randomized into an observation group and a control group,with 28 cases in each *** acupoints were selected in the two groups:Cuanzhu(BL 2),Sizhukong(TE 23),Taiyang(EX-HN 5)and Fengchi(GB 20)were chosen as the major points and Feishu(BL 13)and Chize(LU 5)as the *** Long Xi Zhu and Guo Yan Re needling manipulations were applied in the observation group while twirling reinforcing manipulation was used in the control *** was conducted once per day in both groups,for two sets of 15 consecutive days at a 2-day *** in the symptom score,tear break-up time(BUT)and tear production were observed afterwards,and the clinical efficacy was also compared between the two ***:The total effective rate was 92.8%in the observation group,higher than 71.4%in the control group,and the between-group difference was statistically significant(Ptear BUT and tear production showed significant improvements in both groups(all Ptear production in the observation group were significantly different from those in the control group(all P<0.05).Conclusion:Given the same acupoint selection,combining Er Long Xi Zhu and Guo Yan Re needling manipulations can produce more significant clinical efficacy than twirling reinforcing manipulation in treating DES of lung-yin deficiency pattern.

关键词： Acupuncture Therapy Acupuncture Reinforcing Method tear Break-up Time tear secretion Lung-yin Deficiency Dry Eye Syndrome

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