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targeted Blue nanoparticles as Photoacoustic Contrast Agent for Brain Tumor Delineation

Nano Research 2011年第11期4卷 1163-1173页

作者： Aniruddha Ray Xueding Wang Yong-Eun Koo Lee Hoe Jin Hah Gwangseong Kim Thomas Chen Daniel A. Orringer Oren Sagher Xiaojun Liu Raoul Kopelman Biophysics University of Michigan Ann Arbor MI 48109 USA Department of Radiology University of Michigan Ann Arbor MI 48109 USA Department of Chemistry University of Michigan Ann Arbor MI 48109 USA Department of Neurosurgery University of Michigan Ann Arbor MI 48109 USA Institute of Acoustics Naniing University Nanjing 210093 China

Distinguishing a tumor from non-neoplastic tissue is a challenging task during cancer surgery. Several attempts have been made to use visible or fluorescent agents to aid in the visualization of a tumor during surgery. We describe a novel method to delineate brain tumors, using a highly sensitive photoacoustic imaging technique that is enhanced by tumor-targeting blue nanoparticles serving as a contrast agent. Experiments on phantoms and on rat brains, ex vivo, demonstrate the high sensitivity of photoacoustic imaging in delineating tumors containing contrast agent at a concentration much lower than needed for visualization by the naked eye. The limit of detection of the system for the nanoparticles is about 0.77 μg/mL in water （equivalent to 0.84 μmol/L Coomassie Blue dye）. The present exploratory study suggests that photoacoustic imaging, when used with strongly optical absorbing contrast agents, could facilitate cancer surgery intraoperatively by revealing the distribution and extent of the tumor.

关键词： Brain tumor surgery targeted nanoparticles F3 peptide Coomassie Blue dye photoacoustic imaging

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Breaking the vicious cycle between tumor cell proliferation and bone resorption by chloroquine-loaded and bone-targeted polydopamine nanoparticles

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Science China Materials 2021年第2期64卷 474-487页

作者： Yitong Wang Hui Chen Kaili Lin Ting Ying Quan Huang Xiaopan Cai Jianru Xiao Qiang Zhang Yiyun Cheng Shanghai Key Laboratory of Regulatory Biology School of Life SciencesEast China Normal UniversityShanghai200241China Department of Oral&Cranio-Maxillofacial Surgery Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology&Shanghai Research Institute of StomatologyShanghai200011China College of Life and Environmental Sciences Shanghai Normal UniversityShanghai200234China Department of Orthopedics Oncology Changzheng Hospitalthe Second Military Medical UniversityShanghai200003China South China Advanced Institute for Soft Matter Science and Technology School of Molecular Science and EngineeringSouth China University of TechnologyGuangzhou510640China

The vicious cycle between tumor cell proliferation and bone resorption remarkably elevates the progression and metastasis of bone ***,we fabricated polyethylene glycol-conjugated alendronate-functionalized and chloroquine(CQ)-loaded polydopamine nanoparticles(PPA/CQ)for efficient treatment of bone tumors via breaking the vicious *** nanoparticles were efficiently accumulated to the bone tissues,especially the osteolytic lesions around *** released from PPA/CQ inhibited osteoclastogenesis via preventing the degradation of tumor necrosis factor(TNF)receptor-associated receptor 3 to attenuate the osteolysis in bone *** the other hand,CQ blocked the autophagy in cancer cells,resulting in improved photothermal killing of cancer ***,the in vivo experiment revealed that PPA/CQ-associated treatment efficiently inhibited both tumor growth and *** work suggests that autophagy inhibition-associated photothermal therapy could be a promising strategy for treating malignant bone tumors.

关键词： targeted nanoparticles cancer therapy multifunctional nanoparticles drug delivery bone targeting

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Engendered nanoparticles for treatment of brain tumors

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Oncology research 2025年第1期33卷 15-26页

作者： Soroush Soleymani Mohammad Doroudian Mahdieh Soezi Ali Beladi Kiarash Asgari Aso Mobarakshahi Aryana Aghaeipour Ronan Macloughlin Department of Cell and Molecular Biology School of Biological Sciences University of Leicester Leicester LE1 7RH UK. Department of Cell and Molecular Biology Faculty of Biological Sciences Kharazmi University Tehran 15719-14911 Iran. Cancer Epidemiology Research Center Aja University of Medical Sciences Tehran 14117-18541 Iran. Medical Biotechnology Research Center Aja University of Medical Sciences Tehran 14117-18541 Iran. Department of Life Sciences Faculty of Natural Sciences Imperial College London London SW7 2AZ UK. School of Pharmacy and Biomolecular Sciences Royal College of Surgeons in Ireland (RCSI) Dublin D02 YN77 Ireland. Research and Development Science and Emerging Technologies Aerogen Ltd. Galway Business Park Galway H91 HE94 Ireland. School of Pharmacy and Pharmaceutical Sciences Trinity College Dublin D02 PN40 Ireland.

Brain metastasis and primary glioblastoma multiforme represent the most common and lethal malignant brain tumors. Its median survival time is typically less than a year after diagnosis. One of the major challenges in treating these cancers is the efficiency of the transport of drugs to the central nervous system. The blood-brain barrier is cooperating with advanced stages of malignancy. The blood-brain barrier poses a significant challenge to delivering systemic medications to brain tumors. Nanodrug delivery systems have emerged as promising tools for effectively crossing this barrier. Additionally, the development of smart nanoparticles brings new hope for cancer diagnosis and treatment. These nanoparticles improve drug delivery efficiency, allowing for the creation of targeted and stimuli-responsive delivery methods. This review highlights recent advancements in nanoparticle and smart nanoparticle technologies for brain cancer treatment, exploring the range of nanoparticles under development, their applications, targeting strategies, and the latest progress in enhancing transport across the blood-brain barrier. It also addresses the ongoing challenges and potential benefits of these innovative approaches.

关键词： Blood-brain barrier (BBB) Brain cancer nanoparticles Smart nanoparticles Stimuli responsive nanoparticles targeted nanoparticles

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