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Cadmium nanoclusters in a protein matrix： Synthesis, characterization, and application in targeted drug delivery and cellular imaging

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Nano Research 2016年第11期9卷 3229-3246页

作者： Morteza Sarparast Abolhassan Noori Hoda Ilkhani S. Zahra Bathaie Maher F. EI-Kady Lisa J. Wang Huong Pham Kristofer L. Marsh Richard B. Kaner Mir F. Mousavi Department of Chemistry Tarbiat Modares University Tehran 14115-175 Iran Department of Clinical Biochemistry Faculty of Medical Sciences Tarbiat Modares University Tehran 14115-111 Iran Department of Chemistry and Biochemistry University of California Los Angeles Los Angeles CA 90095 USA Department of Chemistry Faculty of Science Cairo University Giza 12613 Egypt California NanoSystems Institute University of California Los Angeles Los Angeles CA 90095 USA

Biotemplated metal nanoclusters have garnered much attention owing to their wide range of potential applications in biosensing, bioimaging, catalysis, and nanomedicine. Here, we report the synthesis of stable, biocompatible, watersoluble, and highly fluorescent bovine serum albumin-templated cadmium nanoclusters （CdNcs） through a facile one-pot green method. We covalently conjugated hyaluronic acid （HA） to the CdNcs to form a pH-responsive, tumor- targeting theranostic nanocarrier with a sustained release profile for doxorubicin （DOX）, a model anticancer drug. The nanocarrier showed a DOX encapsulation efficiency of about 75.6%. DOX release profiles revealed that 74% of DOX was released at pH 5.3, while less than 26% of DOX was released at pH 7.4 within the same 24-h period. The nanocarrier selectively recognized MCF-7 breast cancer cells expressing CD44, a cell surface receptor for HA, whereas no such recognition was observed with HA receptor-negative HEK293 cells. Biocompatibility of the nanocarrier was evaluated through cytotoxicity assays with HEK293 and MCF-7 ceils. The nanocarrier exhibited very low to no cytotoxicity, whereas the DOX-loaded nanocarrier showed considerable cellular uptake and enhanced MCF-7 breast cancer cell-killing ability. We also confirmed the feasibility of using the highly fluorescent nanoconjugate for bioimaging of MCF-7 and HeLa cells. The superior targeted drug delivery efficacy, cellular imaging capability, and low cytotoxicity position this nanoconjugate as an exciting new nanoplatform with promising biomedical applications.

关键词： Cd nanoclusters hyaluronic acid targeted drug delivery fluorescence bioimaging nanocarrier

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MOF-based magnetic microrobot swarms for pH-responsive targeted drug delivery

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Science China Chemistry 2024年第4期67卷 1216-1223页

作者： Qinyi Cao Yifan Zhang Yanping Tang Changjin Wu Jizhuang Wang Dan Li College of Chemistry and Materials Science Jinan UniversityGuangzhou 510632China Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications Jinan UniversityGuangzhou 510632China Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction The Fifth Affiliated Hospital(Heyuan Shenhe People’s Hospital)Jinan UniversityHeyuan 517000China JNU-HKUST Joint Laboratory for Neuroscience and Innovative drug Research College of PharmacyJinan UniversityGuangzhou 510632China Department of Chemistry The University of Hong KongHong KongChina

Metal-organic frameworks(MOFs)hold significant potential as vehicles for drug delivery due to their expansive specific surface area,biocompatibility,and versatile ***,magnetically actuated micro/nano-robots(MNRs)offer distinct advantages,such as untethered and precise *** fusion of these technologies presents a promising avenue for achieving non-invasive targeted drug ***,we report a MOF-based magnetic microrobot swarm(MMRS)for targeted *** approach overcomes limitations associated with a single MNR,including limited drug loading and the risk of loss during *** select Zeolitic Imidazolate Framework-8(ZIF-8)as the drug vehicle for its superior loading potential and p H-sensitive *** design incorporates magnetic responsive components into the one-pot synthesis of Fe@ZIF-8,enabling collective behaviors under *** the yaw angle of alternating magnetic fields and nanoparticles'amount,the MMRSs with controllable size achieve instantaneous transformation among different configurations,including vortex-like swarms,chain-like swarms,and elliptical swarms,facilitating adaptation to environmental *** to the subcutaneous T24 tumor site,the MMRSs with encapsulated doxorubicin(DOX)automatically degrade and release the drug,leading to a dramatic reduction of the tumor in *** investigation signifies a significant advancement in the integration of biodegradable MOFs into microrobot swarms,ushering in new avenues for accurate and non-invasive targeted drug delivery.

关键词： magnetic microrobot swarm MOF nanoparticles magnetic propulsion pH-responsive drug release targeted drug delivery

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Performance Analysis of Magnetic Nanoparticles during targeted drug delivery:Application of OHAM

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Computer Modeling in Engineering & Sciences 2022年第2期130卷 723-749页

作者： Muhammad Zafar Muhammad Saif Ullah Tareq Manzoor Muddassir Ali Kashif Nazar Shaukat Iqbal HabibUllah Manzoor Rizwan Haider Woo Young Kim Institute of Energy and Environmental Engineering University of the PunjabQuaid-e-Azam CampusLahore54590Pakistan Energy Research Centre COMSATS University IslamabadLahore54000Pakistan Department of Energy Engineering Faculty of Mechanical and Aeronautical EngineeringUniversity of Engineering and TechnologyTaxila47080Pakistan Department of Mathematics COMSATS University IslamabadLahore54000Pakistan School of Systems and Technology University of Management Sciences and TechnologyLahore54770Pakistan Department of Electrical Electronics and TelecommunicationEngineeringUniversity of Engineering and TechnologyLahore(FSD Campus)Faisalabad38000Pakistan Department of Electronic Engineering Faculty of Applied Energy SystemJeju National UniversityJeju Special Self-Governing ProvinceJeju-si63243Korea

In recent years,the emergence of nanotechnology experienced incredible development in the field of medical *** the past decade,investigating the characteristics of nanoparticles during fluid flow has been one of the intriguing *** distribution and uniformity have emerged as substantial criteria in both medical and engineering *** effects of chemotherapy on healthy tissues are known to be a significant concern during cancer therapy.A novel treatment method of magnetic drug targeting(MDT)has emerged as a promising topical cancer treatment along with some attractive advantages of improving efficacy,fewer side effects,and reduce drug *** magnetic drug targeting,the appropriate movement of nanoparticles(magnetic)as carriers is essential for the therapeutic process in the blood clot removal,infection treatment,and tumor cell *** this study,we have numerically investigated the behavior of an unsteady blood flowinfused with magnetic nanoparticles during MDT under the influence of a uniform external magnetic field in a *** optimal homotopy asymptotic method(OHAM)is employed to compute the governing equation for unsteady electromagnetohydrodynamics *** influence of Hartmann number(Ha),particle mass parameter(G),particle concentration parameter(R),and electro-osmotic parameter(k)is investigated on the velocity of magnetic nanoparticles and blood *** obtained show that the electro-osmotic parameter,along with Hartmann’s number,dramatically affects the velocity of magnetic nanoparticles,blood flow velocity,and flow ***,results also reveal that at a higher Hartman number,homogeneity in nanoparticles distribution improved *** particle concentration andmass parameters effectively influence the capturing effect on nanoparticles in the blood flow using a micro-tube for magnetic drug ***,investigation also indicates that the OHAM analysis is efficient and quick to h

关键词： Hartmann number magnetic nanoparticles nonlinear analysis targeted drug delivery optimal homotopy asymptotic method(OHAM)

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Design and preparation of a new multi-targeted drug delivery system using multifunctional nanoparticles for co-delivery of siRNA and paclitaxel

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Journal of Pharmaceutical Analysis 2021年第2期11卷 163-173页

作者： Sara Hosayni Nasab Amin Amani Hossein Ali Ebrahimi Ali Asghar Hamidi Department of Agronomy and Plant Breeding Faculty of Agriculture and Natural ResourcesUniversity of Mohaghegh ArdabiliArdabilIran Biotechnology Research Center Tabriz University of Medical SciencesTabrizIran Department of Pharmaceutics School of PharmacyArdabil University of Medical SciencesArdabilIran Department of Medicinal Chemistry Faculty of PharmacyTabriz University of Medical SciencesTabrizIran

drug resistance is a great challenge in cancer therapy using chemotherapeutic agents. Administration of these drugs with siRNA is an efficacious strategy in this battle. Here, the present study tried to incorporate siRNA and paclitaxel(PTX) simultaneously into a novel nanocarrier. The selectivity of carrier to target cancer tissues was optimized through conjugation of folic acid(FA) and glucose(Glu) onto its surface. The structure of nanocarrier was formed from ternary magnetic copolymers based on FeCopolyethyleneimine(FeCo-PEI) nanoparticles and polylactic acid-polyethylene glycol(PLA-PEG) gene delivery system. Biocompatibility of FeCo-PEI-PLA-PEG-FA(NPsA), FeCo-PEI-PLA-PEG-Glu(NPsB) and FeCo-PEI-PLA-PEG-FA/Glu(NPsAB) nanoparticles and also influence of PTX-loaded nanoparticles on in vitro cytotoxicity were examined using MTT assay. Besides, siRNA-FAM internalization was investigated by fluorescence microscopy. The results showed the blank nanoparticles were significantly less cytotoxic at various concentrations. Meanwhile, siRNA-FAM/PTX encapsulated nanoparticles exhibited significant anticancer activity against MCF-7 and BT-474 cell lines. NPsAB/siRNA/PTX nanoparticles showed greater effects on MCF-7 and BT-474 cells viability than NPsA/siRNA/PTX and NPsB/siRNA/***, they induced significantly higher anticancer effects on cancer cells compared with NPsA/siRNA/PTX and NPsB/siRNA/PTX due to their multi-targeted properties using FA and Glu. We concluded that NPsAB nanoparticles have a great potential for co-delivery of both drugs and genes for use in gene therapy and chemotherapy.

关键词： Paclitaxel siRNA targeted drug delivery Magnetic nanoparticles Polymeric drug delivery

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Layered Double Hydroxide Modified by PEGylated Hyaluronic Acid as a Hybrid Nanocarrier for targeted drug delivery

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Transactions of Tianjin University 2016年第3期22卷 237-246页

作者：董岸杰李雪王伟伟韩尚聪刘鉴锋刘金剑赵军强许舒欣邓联东 Key Laboratory of Systems Bioengineering of Ministry of Education School of Chemical Engineering and Technology Tianjin University Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical Engineering Chinese Academy of Medical Science Tianjin Key Laboratory of Radiation Molecular and Molecular Nuclear Medicine Institute of Radiation MedicineChinese Academy of Medical Science and Peking Union Medical College School of Materials Science and Engineering Tianjin Polytechnic University

In recent years, organic-inorganic hybrid nanocarriers are explored for effective drug delivery and preferable disease treatments. In this study, using 5-fluorouracil(5-FU)as electronegative model drug, a new type of organic-inorganic hybrid drug delivery system(LDH/HA-PEG/5-FU)was conceived and manufactured by the adsorption of PEGylated hyaluronic acid(HA-PEG)on the surface of layered double hydroxide(LDH, prepared via hydrothermal method)and the intercalation of 5-FU in the interlamination of LDH via ion exchange strategy. The drug loading amount of LDH/HA-PEG/5-FU achieved as high as 34.2%. LDH, LDH/5-FU and LDH/HA-PEG/5-FU were characterized by FT-IR, XRD, TGA, laser particle size analyzer and SEM. With the benefit of p Hdegradable feature of LDH and enzyme-degradable feature of HA, LDH/HA-PEG/5-FU showed p H-degradable and enzyme-degradable capacity in in vitro drug release. Moreover, the drug carrier LDH/HA-PEG contained biocompatible PEG and tumor-targeted HA, resulting in lower cytotoxicity and better endocytosis compared with LDH in vitro. It was suggested that the organic-inorganic hybrid drug delivery system, which was endowed with the properties of controlled release, low toxicity and tumor-targeting delivery for ameliorative cancer therapy, was advisable and might be applied further to fulfill other treatments.

关键词： layered double hydroxide HA-PEG, intercalation/adsorption controlled release targeted drug delivery

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Folate-conjugated nanodiamond for tumor-targeted drug delivery

Folate-conjugated nanodiamond for tumor-targeted drug delive...

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中国化学会第九届全国无机化学学术会议

作者： Yu Dong Zhiqin Wang Lin Li Lu Tian Yingqi Li Department of Chemistry College of Chemistry and Chemical Engineering Shanxi University

An effective drug delivery system（NPFD） based on the functionalized nanodiamond（ND） is constructed by layer-by-layer self-assembly, which exhibits excellent stability under neutral p H conditions, while greatly releases DOX at acidic extracellular fluids（pH 6.5 or pH 5.5）（Fig.1A）. Relying on the role of folate and folate receptor, NPFD nanoparticles tend to selectively discriminate tumor cells from normal cells and enter the cells by clathrin-dependent and receptor-mediated endocytosis（Fif.1B）. Interestingly, MTT assay found that NPFD nanoparticles not only played a slower and sustained drug release profile（Fig.1C）, and but also had a tumor-targeted toxicity. This implies that NPFD have a good targeting drug delivery and can act as a nanodrug with promising chemotherapeutic efficacy and safety.

关键词： Nanodiamond folate targeted drug delivery toxicity

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Functionalized liposomes for targeted breast cancer drug delivery

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Bioactive Materials 2023年第6期24卷 401-437页

作者： Janske Nel Kamil Elkhoury Émilie Velot Arnaud Bianchi Samir Acherar Grégory Francius Ali Tamayol Stéphanie Grandemange Elmira Arab-Tehrany Universitéde Lorraine LIBioF-54000NancyFrance LAAS-CNRS F-31400ToulouseFrance Universitéde Lorraine CNRSIMoPAF-54000NancyFrance Universitéde Lorraine CNRSLCPMF-54000NancyFrance Universitéde Lorraine CNRSLCPMEF-54000NancyFrance Department of Biomedical Engineering University of Connecticut Health CenterFarmingtonCT06030USA Universitéde Lorraine CNRSCRANF-54000NancyFrance

Despite the exceptional progress in breast cancer pathogenesis,prognosis,diagnosis,and treatment strategies,it remains a prominent cause of female mortality ***,although chemotherapies are effective,they are associated with critical limitations,most notably their lack of specificity resulting in systemic toxicity and the eventual development of multi-drug resistance(MDR)cancer *** have proven to be an invaluable drug delivery system but of the multitudes of liposomal systems developed every year only a few have been approved for clinical use,none of which employ active *** this review,we summarize the most recent strategies in development for actively targeted liposomal drug delivery systems for surface,transmembrane and internal cell receptors,enzymes,direct cell targeting and dual-targeting of breast cancer and breast cancer-associated cells,e.g.,cancer stem cells,cells associated with the tumor microenvironment,etc.

关键词： Liposomes Breast cancer Anti-cancer agents targeted drug delivery Surface functionalization Receptor-targeted drug delivery

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Targeting capabilities of engineered extracellular vesicles for the treatment of neurological diseases

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Neural Regeneration Research 2025年第11期20卷 3076-3094页

作者： Xinyu Yang Xiangyu Gao Xiaofan Jiang Kangyi Yue Peng Luo Department of Neurosurgery Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina

Recent advances in research on extracellular vesicles have significantly enhanced their potential as therapeutic agents for neurological *** to their therapeutic properties and ability to cross the blood–brain barrier,extracellular vesicles are recognized as promising drug delivery vehicles for various neurological conditions,including ischemic stroke,traumatic brain injury,neurodegenerative diseases,glioma,and ***,the clinical application of natural extracellular vesicles is hindered by their limited targeting ability and short clearance from the *** address these limitations,multiple engineering strategies have been developed to enhance the targeting capabilities of extracellular vesicles,thereby enabling the delivery of therapeutic contents to specific tissues or ***,this review aims to highlight the latest advancements in natural and targeting-engineered extracellular vesicles,exploring their applications in treating traumatic brain injury,ischemic stroke,Parkinson's disease,Alzheimer's disease,amyotrophic lateral sclerosis,glioma,and ***,we summarized recent clinical trials involving extracellular vesicles and discussed the challenges and future prospects of using targeting-engineered extracellular vesicles for drug delivery in treating neurological *** review offers new insights for developing highly targeted therapies in this field.

关键词： Alzheimer's disease amyotrophic lateral sclerosis engineered extracellular vesicles glioma ischemic stroke neurological diseases Parkinson's disease psychosis targeted drug delivery traumatic brain injury

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drug targeting through platelet membrane-coated nanoparticles for the treatment of rheumatoid arthritis

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Nano Research 2018年第11期11卷 6086-6101页

作者： Yuwei He Ruixiang Li Jianming Liang Ying Zhu Shuya Zhang Zicong Zheng Jing Qin Zhiqing Pang Jianxin Wang Department of Pharmaceutics School of Pharmacy Fudan University & Key Laboratory of Smart Drug Delivery Ministry of Education Shanghai 201203 China Institute of Clinical Pharmacology Guangzhou University of Traditional Chinese Medicine Guangzhou 510006 China

The effective drug treatment of rheumatoid arthritis (RA) is hindered by poor delivery efficiency to the diseased site and the serious side effects caused by wide-spread drug distribution. Traditional drug-targeting strategies, such as ligand modification, are complex, laborious, and inefficient. Inspired by the intrinsic relationship between platelets and RA, platelet-mimetic nanoparticles (PNPs) were developed for targeted drug delivery in RA. Through platelet receptor-mediated adhesion, an intact platelet membrane was coated onto poly (lactic-co-glycolic acid) nanoparticles, endowing the resulting PNPs with various functional receptors. By coating with platelet membranes, the nanoparticles were stabilized and had a better circulation profile, providing a benefit for passive targeting. In vitro binding of PNPs to inflamed endothelium, and in vivo accumulation in joints of a collagen-induced arthritis (CIA) mouse model of RA were significantly improved via P-selectin and GVPI recognition, indicating that the PNPs could effectively target to RA tissues through multiple mechanisms, similar to natural platelets. Moreover, FK506, a model drug, was loaded into the PNPs and used to treat RA. Pharmacodynamic studies demonstrated that the FK506-PNPs had a notable anti-arthritic effect in CIA mice. This study provides a new biomimetic targeting strategy with great potential for the treatment of RA.

关键词： biomimetic nanoparticles platelet membrane rheumatoid arthritis targeted drug delivery

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A STIR nucleic acid drug delivery system for stirring phenotypic switch of microglia in Parkinson’s disease treatments

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Nano Research 2023年第5期16卷 7216-7226页

作者： Yanyue Wu Wenli Wang Xinyu Qiu Zhiguo Lu Weihong Ji Jie Shen Huan Peng Ruichen Zhao Jingwen Wang Tianlu Zhang Jun Yang Xin Zhang State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

Neuroinflammation is one of the three important pathological features in neurodegenerative diseases including Parkinson’s disease(PD).The regulation of neuroinflammation can reduce the severity of neurological damage to alleviate *** studies have shown that the phenotype switch of microglia is tightly associated with the nuclear factorκB(NF-κB)-mediated inflammatory ***,the small interfering RNA(siRNA)therapy for downregulating the expression of NF-κB,provides a promising therapeutic strategy for Parkinson’s disease *** the brain delivery challenges of siRNA,a sequential targeting inflammation regulation(STIR)delivery system based on poly(amino acid)s is developed to improve the therapeutic effects of Parkinson’s disease *** STIR system sequentially targets the blood–brain barrier and the microglia to enhance the effective concentration of siRNA in the targeted *** results demonstrate that the STIR nanoparticles can transform microglial phenotypes and regulate brain inflammation,thus achieving neuronal recovery and abnormal aggregation ofα-synuclein protein(α-syn)reduction in the treatment of Parkinson’s ***,this STIR delivery system provides a promising therapeutic platform in PD treatments and has great potential for other neurodegenerative diseases’therapies.

关键词： sequential targeting inflammation regulation phenotypic switch of microglia targeted drug delivery siRNA-based gene therapy responsive release Parkinson’s disease

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