Performance Analysis of Magnetic Nanoparticles during Targeted Drug Delivery:Application of OHAM

作     者：Muhammad Zafar Muhammad Saif Ullah Tareq Manzoor Muddassir Ali Kashif Nazar Shaukat Iqbal HabibUllah Manzoor Rizwan Haider Woo Young Kim 

作者机构：Institute of Energy and Environmental EngineeringUniversity of the PunjabQuaid-e-Azam CampusLahore54590Pakistan Energy Research CentreCOMSATS University IslamabadLahore54000Pakistan Department of Energy EngineeringFaculty of Mechanical and Aeronautical EngineeringUniversity of Engineering and TechnologyTaxila47080Pakistan Department of MathematicsCOMSATS University IslamabadLahore54000Pakistan School of Systems and TechnologyUniversity of Management Sciences and TechnologyLahore54770Pakistan Department of ElectricalElectronics and TelecommunicationEngineeringUniversity of Engineering and TechnologyLahore(FSD Campus)Faisalabad38000Pakistan Department of Electronic EngineeringFaculty of Applied Energy SystemJeju National UniversityJeju Special Self-Governing ProvinceJeju-si63243Korea 

出 版 物：《Computer Modeling in Engineering & Sciences》 (工程与科学中的计算机建模（英文）)

年 卷 期：2022年第130卷第2期

页      面：723-749页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：the research grant of Jeju National University in 2020,the Basic Science Research Program through the National Research Foundation of Korea(NRF)grant funded by the Korea Government(Ministry of Science and ICT)(NRF-2018R1A4A1025998) Higher Education Commission of Pakistan(Project No.210-3800/NRPU/R&D/HEC/1530) 

主　　题：Hartmann number magnetic nanoparticles nonlinear analysis targeted drug delivery optimal homotopy asymptotic method(OHAM) 

摘      要：In recent years,the emergence of nanotechnology experienced incredible development in the field of medical *** the past decade,investigating the characteristics of nanoparticles during fluid flow has been one of the intriguing *** distribution and uniformity have emerged as substantial criteria in both medical and engineering *** effects of chemotherapy on healthy tissues are known to be a significant concern during cancer therapy.A novel treatment method of magnetic drug targeting(MDT)has emerged as a promising topical cancer treatment along with some attractive advantages of improving efficacy,fewer side effects,and reduce drug *** magnetic drug targeting,the appropriate movement of nanoparticles(magnetic)as carriers is essential for the therapeutic process in the blood clot removal,infection treatment,and tumor cell *** this study,we have numerically investigated the behavior of an unsteady blood flowinfused with magnetic nanoparticles during MDT under the influence of a uniform external magnetic field in a *** optimal homotopy asymptotic method(OHAM)is employed to compute the governing equation for unsteady electromagnetohydrodynamics *** influence of Hartmann number(Ha),particle mass parameter(G),particle concentration parameter(R),and electro-osmotic parameter(k)is investigated on the velocity of magnetic nanoparticles and blood *** obtained show that the electro-osmotic parameter,along with Hartmann’s number,dramatically affects the velocity of magnetic nanoparticles,blood flow velocity,and flow ***,results also reveal that at a higher Hartman number,homogeneity in nanoparticles distribution improved *** particle concentration andmass parameters effectively influence the capturing effect on nanoparticles in the blood flow using a micro-tube for magnetic drug ***,investigation also indicates that the OHAM analysis is efficient and quick to h