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Differential regulation of clathrin and its adaptor proteins, AP-2 and the tplate complex, during their membrane recruitment in Arabidopsis

Differential regulation of clathrin and its adaptor proteins...

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2016年全国植物生物学大会

作者： Chao Wang Tianwei Hu Xu Yan Tingting Meng Yutong Wang Qingmei Wang Xiaoyue Zhang Ying Gu Clara Sánchez-Rodríguez Astrid Gadeyne Jinxing Lin Staffan Persson Dani?l Van Damme Chuanyou Li Sebastian Y.Bednarek Jianwei Pan College of Chemistry and Life Sciences Zhejiang Normal University Institute of Genetics and Developmental Biology Chinese Academy of Sciences Department of Biochemistry and Molecular Biology Pennsylvania State UniversityUniversity Park Department of Biology Institute of Agricultural SciencesETH Zurich Department of Plant Systems Biology VIBDepartment of Plant Biotechnology and BioinformaticsGhent University College of Biological Sciences and Biotechnology Beijing Forestry University

In plants,clathrin-mediated endocytosis(CME) is dependent on the function of clathrin and its accessory heterooligomeric adaptor protein complexes,Adaptor Protein 2(AP-2) and the tplate complex(TPC),and is negatively regulated by the hormones auxin and salicylic acid(SA). The details for how clathrin and its adaptor complexes are recruited to the plasma membrane(PM) to regulate CME are however poorly understood. We found that SA and the pharmacological CME inhibitor tyrphostin A23(Tyr A23) reduce the membrane association of clathrin and AP-2,but not that of the TPC,whereas auxin solely affected clathrin membrane association,in Arabidopsis thaliana. Genetic and pharmacological experiments revealed that loss of AP2μ or AP2σ partially affected the membrane association of other AP-2 subunits and that the AP-2 subunit AP2σ,but not AP2μ,was required for SA-and Tyr A23-dependent inhibition of CME. Furthermore,we show that although AP-2 and the TPC are both required for the PM recruitment of clathrin in wild-type cells,the TPC is necessary for clathrin PM association in AP-2 deficient cells. These results indicate that developmental signals may differentially modulate the membrane recruitment of clathrin and its core accessory complexes to regulate the process of CME in plant cells.

关键词： Adaptor Protein 2 auxin clathrin endocytosis salicylic acid tplate complex tyrphostin A23 Arabidopsis

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