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Lethal effect and apoptotic DNA fragmentation in response of D-GalN-treated mice to bacterial LPS can be suppressed by pre-exposure to minute amount of bacterial LPS: Dual role of tnf receptor 1

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World Journal of Gastroenterology 2005年第22期11卷 3398-3404页

作者： Bing-RongZhou MarinaGumenscheimer MarinaA.Freudenberg ChrisGalanos DepartmentofMicrobiology SecondMilitaryMedicalUniversityShanghai200433China Max-Planck-InstitutfiirImmunbiologieStubeweg51D-79108FreiburginBr.Germany

AIM: To investigate whether induction of tolerance of mice to lipopolysaccharide (LPS) was able to inhibit apoptotic reaction in terms of characteristic DNA fragmentation and protect mice from lethal effect. METHODS: Experimental groups of mice were pretreated with non-lethal amount of LPS (0.05 μg). Both control and experimental groups simultaneously were challenged with LPS plus D-GaIN for 6-7 h. The evaluations of both DNA fragmentations from the livers and the protection efficacy against lethality to mice through induction of tolerance to LPS were conducted. RESULTS: In the naive mice challenge with LPS plus D-GaIN resulted in complete death in 24 h, whereas a characteristic apoptotic DNA fragmentation was exclusively seen in the livers of mice receiving LPS in combination with D-GaIN. The mortality in the affected mice was closely correlated to the onset of DNA fragmentation. By contrast, in the mice pre-exposed to LPS, both lethal effect and apoptotic DNA fragmentation were suppressed when challenged with LPS/D-GalN. In addition to LPS, the induction of mouse tolerance to tnf also enabled mice to cross-react against death and apoptotic DNA fragmentation when challenged with tnf and/or LPS in the presence of D-GaIN. Moreover, this protection effect by LPS could last up to 24 h. tnfR1 rather than tnfR2 played a dual role in signaling pathway of either induction of tolerance to LPS for the protection of mice from mortality or inducing morbidity leading to the death of mice. CONCLUSION: The mortality of D-GalN-treated mice in response to LPS was exceedingly correlated to the onset of apoptosis in the liver, which can be effectively suppressed by brief exposure of mice to a minute amount of LPS. The induced tolerance status was mediated not only by LPS but also by tnf. The developed tolerance to either LPS or tnf can be reciprocally cross-reacted between LPS and tnf challenges, whereas the signaling of induction of tolerance and promotion of apoptosis was through T

关键词： LPS tolerance DNA fragmentation Apoptosis tnf receptor

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Fish tnf and tnf receptors

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Science China(Life Sciences) 2021年第2期64卷 196-220页

作者： Yaoguo Li Tiaoyi Xiao Jun Zou Hunan Engineering Technology Research Center of Featured Aquatic Resources Utilization Hunan Agricultural UniversityChangsha 410128China Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources Ministry of EducationShanghai Ocean UniversityShanghai 201306China International Research Center for Marine Biosciences at Shanghai Ocean University Ministry of Science and TechnologyShanghai 201306China ALaboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China

Tumor necrosis factors(tnfs)are a group of cytokines that play critical roles in regulating a diverse range of physiological processes in *** function by activating a large number of structurally related receptors,leading to tnf mediated biological processes which are evolutionarily *** have a much diversified tnf family,partly due to the whole genome duplication events which have occurred in this lineage,providing an excellent model to investigate the neo-and subfunctionalised properties of tnf *** possess most of the tnfs and receptors found in mammals and also some homologues exclusively present in *** seems that tnfSF4(OX40),tnfSF7(CD27)and tnfSF8(CD30)and their cognate receptors are absent in *** has been shown that fish viruses are able to produce tnfR homologues to establish infection by manipulating the host immune *** the roles of tnfSFs in fish immune defence and the pathogenesis of fish diseases will provide insights into the functions of tnfSFs from an evolutionary perspective and better strategies for improving fish health and welfare in *** review summarises recent advances in the study of fish tnf biology and focuses on the molecular properties and immunological functions of the tnf and tnfR superfamily.

关键词： tumor necrosis factor superfamily tnf receptor cytokine evolution fish

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