Fish TNF and TNF receptors

作     者：Yaoguo Li Tiaoyi Xiao Jun Zou Yaoguo Li;Tiaoyi Xiao;Jun ZOU

作者机构：Hunan Engineering Technology Research Center of Featured Aquatic Resources UtilizationHunan Agricultural UniversityChangsha 410128China Key Laboratory of Exploration and Utilization of Aquatic Genetic ResourcesMinistry of EducationShanghai Ocean UniversityShanghai 201306China International Research Center for Marine Biosciences at Shanghai Ocean UniversityMinistry of Science and TechnologyShanghai 201306China ALaboratory for Marine Biology and BiotechnologyQingdao National Laboratory for Marine Science and TechnologyQingdao 266237China 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2021年第64卷第2期

页      面：196-220页

核心收录：

学科分类：0906[农学-兽医学] 09[农学] 

基　　金：funded by the National Key R&D Program of China(2018YFD0900302),National Natural Science Foundation of China(31802288,31572615) China Postdoctoral Science Foundation(2017M612560,2018T110833) 

主　　题：tumor necrosis factor superfamily TNF receptor cytokine evolution fish 

摘      要：Tumor necrosis factors(TNFs)are a group of cytokines that play critical roles in regulating a diverse range of physiological processes in *** function by activating a large number of structurally related receptors,leading to TNF mediated biological processes which are evolutionarily *** have a much diversified TNF family,partly due to the whole genome duplication events which have occurred in this lineage,providing an excellent model to investigate the neo-and subfunctionalised properties of TNF *** possess most of the TNFs and receptors found in mammals and also some homologues exclusively present in *** seems that TNFSF4(OX40),TNFSF7(CD27)and TNFSF8(CD30)and their cognate receptors are absent in *** has been shown that fish viruses are able to produce TNFR homologues to establish infection by manipulating the host immune *** the roles of TNFSFs in fish immune defence and the pathogenesis of fish diseases will provide insights into the functions of TNFSFs from an evolutionary perspective and better strategies for improving fish health and welfare in *** review summarises recent advances in the study of fish TNF biology and focuses on the molecular properties and immunological functions of the TNF and TNFR superfamily.